• PMID: 9804230
• Gene Name: LHB
• Condition: Idiopathic oligoasthenozoospermia
• Association: Associated
• Population size: 30
• Population details: 30 (10 with proven fertility, 10 oligoasthenozoospermic (OAZ) with an altered altered monophasic (no first peak) response, 10 oligoasthenozoospermic (OAZ) with a normal biphasic response)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: LH
• Other associated phenotypes: Idiopathic oligoasthenozoospermia

Altered luteinizing hormone pulsatility in infertile patients with idiopathic oligoasthenozoospermia

Scaglia HE, Timossi CM, Carrere CA, Zylbersztein C, Colombani ME, Rey-Valzacchi G, Aquilano DR.

In a previous study, we demonstrated that oligoasthenozoospermic (OAZ) patients had two types of testosterone response to human chorionic gonadotrophin (HCG) administration: group 1 (OAZ-1) had an altered, monophasic (no first peak) response, and group 2 (OAZ-2) had a normal biphasic response. The objective of the present work was to study the luteinizing hormone (LH) pulsatility in OAZ-1 compared with both OAZ-2 and men of proven fertility (PF), in order partly to determine the possible aetiology of the blunted acute testosterone response to HCG in these patients. LH pulsatility was measured in 10 PF, 10 OAZ-1 and 10 OAZ-2 patients, in blood samples taken every 5 min for 6 h in PF, and for 4 h in OAZ patients. LH values were determined by a time-resolved immunofluorometric assay. Frequency and amplitude of the LH pulses were determined by a computer program. LH pulse frequency, expressed as pulses/4 h, was significantly lower in OAZ-1 (1.5+/-0.97) than in PF (2.4+/-0.63) and OAZ-2 (2.4+/-0.84) patients. In six OAZ-1 and two OAZ-2 patients, LH pulsatility was diminished, as they showed less than two pulses/4 h. No statistically significant differences in LH pulse amplitude were found. These results, together with a higher number of OAZ-1 cases found with decreased LH pulsatility, suggest that, at least in a subset of these men, quantitative and/or qualitative alterations of LH secretion might have occurred. FAU - Scaglia, H E AU - Scaglia HE AD - Instituto de Análisis Bioquímicos de Endocrinología, La Plata, Argentina. FAU - Timossi, C M AU - Timossi CM FAU - Carrere, C A AU - Carrere CA FAU - Zylbersztein, C AU - Zylbersztein C FAU - Colombani, M E AU - Colombani ME FAU - Rey-Valzacchi, G AU - Rey-Valzacchi G