|
|
| Pathways | Gene |
|---|
| 2-Oxocarboxylic acid metabolism | CS, GOT1, GOT2, GPT, IDH2, IDH3A, IDH3B, IDH3G, ACO1, ACO2, AADAT, BCAT1, BCAT2, GPT2, IDH1 |
| ABC transporters | ABCC5, ABCB6, ABCC9, ABCC4, ABCA7, ABCA10, ABCB8, ABCA13, DEFB1, ABCA2, ABCA3, ABCD1, ABCB7, ABCD2, ABCB10, ABCB9, ABCA6, ABCA5, ABCA4, ABCA12, ABCB5, ABCC6, ABCB4, ABCD4, ABCG4, ABCC8, TAP1, TAP2, ABCC11, ABCB11, ABCC3, ABCC10, ABCC12, ABCG2, ABCG1, RAF1, MET, MYC, NFE2L2 |
| Acute myeloid leukemia | AKT3, CEBPE, PIM2, CSF1R, EIF4EBP1, AKT2, GRB2, HRAS, IKBKB, IL3, ITGAM, JUP, KRAS, MPO, LEF1, PIK3CD, PIK3R1, PIK3R2, PML, PPARD, MAP2K1, MAP2K2, RARA, CCND1, BCL2A1, RELA, RPS6KB1, RPS6KB2, SOS2, SPI1, BRAF, STAT5A, STAT5B, TCF7, ZBTB16, TCF7L1, PIK3R3, IKBKG, RUNX1, RUNX1T1, PER2, DUSP6, AKT1, FLT3, MTOR, KIT, MYC, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, BAD, RAF1, RARA, SOS1, STAT3, TCF7L2, CCNA1, PIK3CB, RARA |
| Adherens junction | WASF2, BAIAP2, SORBS1, WASF3, SSX2IP, CREBBP, CSNK2A1, CTNNA1, CTNNA2, CTNND1, EP300, FER, CTNNA3, SMAD3, SMAD4, AFDN, LEF1, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRM, NECTIN1, RAC1, RAC2, RAC3, MAP3K7, TCF7, TGFBR1, TGFBR2, TJP1, ACTG1, VCL, WAS, ACTN4, NECTIN4, TCF7L1, ACTN1, IQGAP1, WASF1, FARP2, CSNK2A2, CSNK2B, CTNNB1, EGFR, ERBB2, FGFR1, FYN, NECTIN3, IGF1R, INSR, RHOA, MET, ACP1, MAPK1, MAPK3, PTPRJ, NECTIN2, ACTB, SNAI2, SNAI1, SRC, TCF7L2, YES1, WASL, CDC42, CDH1, RHOA, NECTIN2, SNAI2, SNAI1 |
| Adipocytokine signaling pathway | AKT3, CAMKK2, PPARGC1A, CPT1C, CPT1A, CPT1B, AKT2, ACSL1, ACSL3, ACSL4, ACSBG1, ACSL6, ACACB, IKBKB, IRS1, JAK2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK2, ADIPOR1, PRKAG2, ACSL5, POMC, PPARA, PRKAA2, PRKAB1, PRKCQ, MAPK9, MAPK10, G6PC2, RELA, RXRG, SLC2A4, TNF, TRAF2, ADIPOR2, ACSBG2, IRS4, IKBKG, IRS2, TRADD, SOCS3, ADIPOQ, CD36, AKT1, MTOR, LEP, LEPR, NFKB1, PRKAA1, MAPK8, PTPN11, RXRA, RXRB, SLC2A1, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, G6PC3, PRKAA1, RXRA, RXRB, SLC2A1, STK11 |
| Adrenergic signaling in cardiomyocytes | AKT3, CACNG3, CACNG2, RAPGEF3, CREB3, RAPGEF4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, ADRA1D, PIK3R6, ADRA1B, ADRA1A, ADRB1, ADRB2, CALML6, AGT, AGTR1, ADCY4, AKT2, PIK3R5, CACNG4, GNAI2, GNAI3, GNAQ, KCNE1, MYH6, MYL2, MYL3, MYL4, ATF4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CALML5, PIK3CG, PLCB2, PLCB3, PLN, PPP1CB, PPP1R1A, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, PRKACB, PRKACG, CACNA2D3, PPP2R2D, MAPK11, MAPK13, CACNG8, CACNG7, CACNG6, RYR2, MAPK12, SCN1B, SCN4B, SCN5A, CREB3L2, SLC8A2, SLC8A1, SLC8A3, SLC9A1, ACTC1, TPM2, TPM3, TPM4, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB3L3, CALML4, RPS6KA5, CACNA2D2, CACNA2D4, CREB5, ADCY1, ADCY2, ADCY3, CREB1, CREM, MAPK14, CREB3L4, AKT1, PLCB1, GNAI1, GNAS, KCNQ1, MYH7, ATP2B4, PPP1CC, PPP2CB, PRKACA, PRKCA, MAPK1, MAPK3, BCL2, TPM1, CACNA1S, CACNA2D1, C |
| African trypanosomiasis | IDO2, GNAQ, HBA1, HBA2, HBB, HPR, APOA1, IDO1, LAMA4, MYD88, PLCB2, PLCB3, TLR9, PRKCB, PRKCG, THOP1, TNF, VCAM1, APOL1, F2RL1, PLCB1, ICAM1, IFNG, FAS, IL1B, FASLG, IL6, IL10, IL12A, IL18, PRKCA, TNF, PRKCA |
| AGE-RAGE signaling pathway in diabetic complications | AKT3, CDKN1B, COL1A2, COL3A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, CYBB, DIAPH1, AGER, AGT, AGTR1, EDN1, EGR1, AKT2, NOX1, HRAS, JAK2, KRAS, SMAD2, SMAD3, SMAD4, NFATC1, PLCE1, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PLCD1, PLCG2, PRKCB, PRKCD, PRKCE, PRKCZ, MAPK11, MAPK9, MAPK10, MAPK13, RAC1, CCND1, RELA, MAPK12, CCL2, STAT5A, STAT5B, TGFB2, TGFBR1, TGFBR2, THBD, TNF, VCAM1, VEGFB, VEGFC, PLCD4, PIK3R3, COL1A1, MAPK14, AKT1, F3, FOXO1, PLCB1, FN1, ICAM1, IL1A, IL1B, IL6, CXCL8, JUN, MMP2, NFKB1, NOS3, SERPINE1, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, MAPK8, BAX, BCL2, STAT1, STAT3, TGFB1, TGFB3, TNF, VEGFA, CASP3, CDC42, PIK3CB, PLCG1, PRKCA |
| Alanine, aspartate and glutamate metabolism | ADSS1, CPS1, ADSL, ADSS2, ABAT, AGXT, FOLH1, GAD1, GAD2, GFPT1, GLS2, GLS, GLUD1, GLUD2, GLUL, GOT1, GOT2, RIMKLA, GPT, NAT8L, ASL, ASNS, ASPA, ASS1, PPAT, RIMKLB, CAD, ALDH5A1, GPT2, DDO, ALDH4A1, PIK3CB, CYCS, BAX, IL4I1, GFPT2 |
| Alcoholism | HDAC6, HDAC5, CREB3, CAMKK2, GNB5, ADCY5, GRIN3A, GRIN3B, H3C14, H2BU1, ADORA2A, ADORA2B, ATF2, ATF6B, CRH, CALML6, DDC, DRD1, DRD2, SLC29A1, H2AC1, FOSB, SHC2, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, H2BW2, GRB2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, H2AC8, H2AC7, H2AZ1, H2BC5, H2BC3, H3-3A, H3-3B, HDAC2, SLC29A2, H2AC21, HRAS, KRAS, SHC4, ATF4, H2AB2, H2AB1, NPY, NTRK2, HDAC7, PDYN, GNG13, CALML5, SHC3, GNG2, PPP1CB, SLC29A3, H4C15, MACROH2A2, PRKACB, PRKACG, PKIA, H2AJ, HDAC8, GNG12, MAP2K1, GNB4, SHC1, CREB3L2, SLC6A3, SLC18A2, SOS2, BRAF, TH, H2AC19, HDAC11, CALM2, CALM3, CALML3, H2AC13, H2AC15, H2AC16, H2AC6, H2AC4, H2AC17, H2AC18, H2AC20, H2BC8, H2BC15, H2BC6, H2BC9, H2BC10, H2BC4, H2BC17, H2BC21, H3C4, H3C3, H3C6, H3C11, H3C12, H3C10, H3C2, H4C1, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C5, H4C13, H4C7, H2AB3, HDAC10, PPP1R1B, CAMKK1, CREB3L3, HAT1, H2AC12, H2BC12, HDAC3, CALML4, GNG8, H2AZ2, MACROH2A1, CREB5, HDAC9, HDAC4, HIST4H4, CREB1, CREB3L4, H2BFWT, H |
| Aldosterone synthesis and secretion | CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, CALML6, AGT, AGTR1, ADCY4, DAGLB, PRKD3, PRKD2, GNA11, GNAQ, NR4A1, ITPR1, ITPR2, ITPR3, KCNK3, LDLR, MC2R, ATF1, ATF4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, NPR1, ATP2B1, ATP2B2, ATP2B3, NR4A2, PDE2A, CALML5, PLCB2, PLCB3, POMC, PRKACB, PRKACG, PRKCB, PRKCE, PRKCG, PRKD1, CAMK1D, CREB3L2, STAR, DAGLA, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB3L3, CAMK1, CACNA1I, CACNA1H, CACNA1G, CALML4, SCARB1, CREB5, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CYP11A1, CYP11B2, CYP21A2, PLCB1, GNAS, HSD3B1, HSD3B2, KCNJ5, LIPE, ATP2B4, KCNK9, PRKACA, PRKCA, CACNA1S, CALM1, CAMK4, ADCY1, ADCY3, CREB1, CREB3L4, KCNJ5, ATP2B4, PRKACA, PRKCA, CALM1 |
| Aldosterone-regulated sodium reabsorption | NEDD4L, SFN, HSD11B2, INS, IRS1, KCNJ1, KRAS, NR3C2, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, PDPK1, PIK3CD, PIK3R1, PIK3R2, FXYD4, PRKCB, PRKCG, SCNN1A, SCNN1B, SCNN1G, SGK1, PIK3R3, SLC9A3R2, IGF1, INSR, PIK3CA, PIK3CB, PRKCA, MAPK1, MAPK3, PIK3CB, PRKCA |
| Allograft rejection | GZMB, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, TNF, CD28, CD80, CD86, CD40, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, IFNG, FAS, IL2, FASLG, IL4, IL5, IL10, IL12A, PRF1, TNF |
| alpha-Linolenic acid metabolism | PLAAT3, PLB1, PLA2G2D, ACAA1, PLA2G3, ACOX1, PLA2G1B, PLA2G4A, PLA2G5, PLA2G12A, ACOX3, PLA2G10, PLA2G12B, PLA2G4C, FADS2, HLA-E, HLA-G |
| Alzheimer disease | AKT3, NDUFC2-KCTD14, PPIF, CDK5, PSMD14, APC2, RTN3, TUBB4A, TUBB4B, ATP5PD, GPR83, UQCR11, ADRM1, TUBA3E, CHRM1, CHRM3, CHRM5, TUBA3D, CHRNA7, CSNK1A1L, COX6B2, NDUFA11, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, PSMA8, CSNK1A1, CSNK1E, CSNK2A1, KLC3, CYBB, CYC1, CALML6, DDIT3, COX7B2, AGER, DVL1, DVL2, DVL3, EIF2S1, TUBB, AKT2, ERN1, DKK1, ATG2A, FRAT2, BACE1, FZD2, BACE2, WIPI2, NOX1, UQCRQ, DKK4, DKK2, GNAQ, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SLC25A4, GRM5, SLC25A5, SLC25A6, UQCR10, NRBF2, HSD17B10, PIK3R4, APBB1, APC, HRAS, IDE, COX8C, TUBB8, IKBKB, INS, IRS1, ITPR1, ITPR2, ITPR3, NDUFS7, KIF5A, KIF5B, KLC1, KRAS, LPL, LRP1, LRP6, LRP5, MAP3K5, MME, UQCRHL, COX2, ND1, ND4L, ND5, ND6, ATF4, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ATP2A1, ATP2A2, ATP2A3, ATP5F1B, |
| Amino sugar and nucleotide sugar metabolism | GNPDA1, GNE, GNPDA2, NANP, CYB5R3, FCSK, GALE, GALK1, GALT, GCK, GFPT1, GMDS, GPI, GMPPB, GMPPA, HK2, HK3, MPI, AMDHD2, CYB5R4, CYB5R2, PGM1, PGM3, PMM1, NANS, PGM2, NAGK, CMAS, RENBP, GNPNAT1, GFUS, UGDH, UGP2, UXS1, HKDC1, NPL, RAP1A, JUN, MYC, PIK3CA, PIK3CB, HK1, GFPT2 |
| Aminoacyl-tRNA biosynthesis | FARSB, WARS2, FARS2, PSTK, MTFMT, TARS3, EARS2, AARS1, EPRS1, FARSA, LARS2, HARS2, PARS2, GARS1, GATC, HARS1, IARS1, KARS1, MARS1, TRNE, NARS1, SEPSECS, LARS1, GATB, SARS2, DARS2, QRSL1, IARS2, RARS2, VARS2, AARS2, QARS1, RARS1, SARS1, TARS1, VARS1, WARS1, CARS2, NARS2, TARS2, CARS1, YARS1, SRC, TRNL1 |
| Amoebiasis | LAMC3, COL1A2, COL3A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, CTSG, GNA11, GNA15, GNAL, GNAQ, CXCL1, CXCL2, CXCL3, HSPB1, IL1R1, ITGAM, ITGB2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, MUC2, SERPINB6, SERPINB9, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PRKACB, PRKACG, PRKCB, PRKCG, PTK2, RAB5A, RAB5B, RAB5C, RELA, SERPINB3, TGFB2, TNF, C8G, VCL, RAB7A, ACTN4, PIK3R3, ACTN1, CD1C, CD1E, GNA14, ADCY1, COL1A1, PLCB1, FN1, GNAS, HSPB1, IFNG, IL1B, IL6, CXCL8, IL10, IL12A, ARG2, LAMA2, NFKB1, NOS2, PRDX1, PIK3CA, PIK3CB, PRKACA, PRKCA, TGFB1, TGFB3, TLR2, TLR4, TNF, IL1R2, CASP3, CD1D, ADCY1, LAMA2, PIK3CB, PRKACA, PRKCA, CD1D |
| Amphetamine addiction | CREB3, ADCY5, GRIN3A, GRIN3B, ATF2, ATF6B, CALML6, DDC, DRD1, FOS, FOSB, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, HDAC2, ATF4, PDYN, CALML5, PPP1CB, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PRKCB, PRKCG, CREB3L2, SLC6A3, SLC18A2, TH, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PPP1R1B, CREB3L3, CALML4, CREB5, CREB1, CREB3L4, SIRT1, GNAS, HDAC1, JUN, MAOA, PPP1CC, PRKACA, PRKCA, SLC18A1, STX1A, CALM1, CAMK4, CREB1, CREB3L4, PPP1CC, PRKACA, PRKCA, SLC18A1, STX1A, CALM1 |
| AMPK signaling pathway | AKT3, CREB3, CAMKK2, PPARGC1A, CPT1C, CPT1A, CPT1B, ADRA1A, EEF2, EIF4EBP1, AKT2, FASN, FBP1, FOXO3, TBC1D1, MLYCD, EEF2K, GYS1, GYS2, ACACA, HMGCR, HNF4A, ACACB, INS, IRS1, RAB8A, PCK2, ADIPOR1, PRKAG2, RAB14, PDPK1, CAB39, PFKFB2, PFKFB4, PFKL, PFKM, PFKP, PIK3CD, PIK3R1, PIK3R2, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, STRADB, PRKAA2, PRKAB1, PPP2R2D, RPTOR, G6PC2, RAB2A, CCND1, RHEB, RPS6KB1, RPS6KB2, SCD, CREB3L2, SLC2A4, SREBF1, MAP3K7, TSC1, TSC2, ADIPOR2, SCD5, CAB39L, ULK1, AKT1S1, CREB3L3, IRS4, PIK3R3, IRS2, FBP2, RAB11B, STRADA, ADIPOQ, CD36, CREB5, CFTR, RAB10, CREB1, CREB3L4, ELAVL1, AKT1, FOXO1, SIRT1, MTOR, IGF1, IGF1R, INSR, LEP, LEPR, LIPE, PFKFB3, PIK3CA, PIK3CB, PPARG, PPP2CB, PRKAA1, STK11, CCNA2, CCNA1, G6PC3, RAB10, CREB1, CREB3L4, PFKFB3, PIK3CB, PPP2R3C, PPP2CB, PRKAA1, STK11 |
| Amyotrophic lateral sclerosis | TOMM40, GPX2, GPX3, GPX7, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAP3K5, NEFM, NEFH, NEFL, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, MAPK11, MAPK13, MAP2K3, MAP2K6, PRPH, ALS2, RAB5A, RAC1, BCL2L1, MAPK12, BID, SLC1A2, TNF, TP53, DERL1, MAPK14, DAXX, GPX1, APAF1, CYCS, BAD, BAX, BCL2, SOD1, TNF, TNFRSF1A, TNFRSF1B, TP53, CASP1, CASP3, CASP9, CAT, DAXX, GPX5 |
| Antifolate resistance | ABCC5, ABCC4, DHFR, DHFR2, FOLR1, FOLR3, FPGS, GART, IKBKB, ATIC, RELA, SHMT1, SHMT2, TNF, TYMS, IKBKG, ABCC3, GGH, ABCG2, IL1B, IL6, ABCC1, MTHFR, NFKB1, SLC19A1, TNF |
| Antigen processing and presentation | IFI30, KIR3DL3, CTSB, CTSL, CTSS, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, HSPA1A, HSPA6, HSPA8, KIR2DL1, KIR2DS4, KIR3DL2, KLRC1, KLRC2, KLRC3, CIITA, NFYA, NFYB, NFYC, LGMN, PSME1, RFX5, RFXAP, TAP1, TAP2, TAPBP, TNF, CALR, CANX, RFXANK, CD4, CD8B, CD74, KIR2DS2, PSME3, CREB1, PDIA3, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA5, HSP90AA1, HSP90AB1, IFNG, KIR2DL2, B2M, TNF, CD8A, PSME3, CREB1, HSP90AB1 |
| Apelin signaling pathway | AKT3, HDAC5, KLF2, GNB5, PPARGC1A, ADCY5, ADCY6, ADCY7, GABARAP, GABARAPL2, ADCY8, ADCY9, PIK3R6, CCN2, CALML6, JAG1, AGTR1, APLNR, EGR1, ADCY4, AKT2, RRAS2, MRAS, PIK3R5, GABARAPL1, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, PIK3R4, HRAS, MYLK4, ITPR1, ITPR2, ITPR3, KRAS, SMAD2, SMAD3, SMAD4, BORCS8-MEF2B, MEF2C, MEF2D, MYL2, MYL3, MYL4, MYLK, NOTCH3, PDE3B, PRKAG2, GNG13, CALML5, PIK3C3, PIK3CG, PLCB2, PLCB3, GNG2, PRKAA2, PRKAB1, PRKACB, PRKACG, PRKCE, GNG12, MAP2K1, MAP2K2, SPHK2, ACTA2, GNB4, CCND1, RPS6, RPS6KB1, RPS6KB2, RRAS, RYR1, RYR2, SLC8A2, SLC8A1, SLC8A3, SLC9A1, SPP1, TFAM, TGFBR1, UCP1, CALM2, CALM3, CALML3, MYLK2, BECN1, MYLK3, CALML4, GNG8, HDAC4, RAF1, SRC, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, JUN, MYC, PIK3CA, PIK3CB, CYCS, BAX, RAF1, SRC, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, JUN, GNA13, ADCY1, ADCY3, PLIN1, PRKAA1, PRKACA, RYR3, CALM1 |
| Apoptosis | AKT3, BCL2L11, PARP3, CTSC, TUBA3E, TUBA3D, PARP4, CSF2RB, CTSB, CTSH, CTSK, CTSL, CTSV, CTSS, CTSW, CTSZ, DAB2IP, GADD45A, DDIT3, DFFA, DFFB, EIF2S1, ENDOG, AKT2, ERN1, FOS, BBC3, HTRA2, GZMB, HRAS, BIRC2, XIAP, IKBKB, IL3, ITPR1, ITPR2, ITPR3, KRAS, LMNB1, MAP3K5, GADD45B, ATF4, NFKBIA, PDPK1, PIK3CD, PIK3R1, PIK3R2, PIDD1, MAPK9, MAPK10, MAP2K1, MAP2K2, DIABLO, PTPN13, BCL2A1, RELA, BCL2L1, BID, TP53AIP1, SPTAN1, ACTG1, TNF, TP53, TRAF1, TRAF2, TUBAL3, CAPN1, CAPN2, CASP2, CASP7, CASP10, TUBA1C, LMNB2, PIK3R3, IKBKG, TRADD, CTSF, HRK, FADD, TNFRSF10B, TNFRSF10A, CFLAR, MAP3K14, AIFM1, EIF2AK3, PARP2, GADD45G, PARP1, CTSD, DAXX, AKT1, APAF1, BIRC5, FAS, FASLG, JUN, MCL1, ATM, NFKB1, NGF, NTRK1, TUBA8, PIK3CA, PIK3CB, SEPTIN4, CYCS, PRF1, MAPK1, MAPK3, MAPK8, BAD, BAK1, BAX, RAF1, BCL2, ACTB, TNF, TNFRSF1A, TP53, TUBA4A, TUBA3C, CASP3, CASP6, CASP8, CASP9, TNFSF10, GADD45G, DAXX, PIK3CB |
| Apoptosis - multiple species | BCL2L11, BBC3, HTRA2, BIRC2, XIAP, NGFR, MAPK9, MAPK10, DIABLO, BIRC6, BCL2L1, BID, BOK, BIRC7, CASP7, BECN1, FADD, APAF1, BIRC5, SEPTIN4, CYCS, MAPK8, BAK1, BAX, BCL2, TNFRSF1A, CASP3, CASP8, CASP9 |
| Arachidonic acid metabolism | PTGES3, PLAAT3, CYP4F8, PRXL2B, PLB1, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP4A11, ALOX5, ALOX12B, ALOX15B, PLA2G2D, GGT1, HPGDS, GPX2, GPX3, GPX7, LTA4H, CYP4F3, LTC4S, PLA2G3, PLA2G1B, PLA2G4A, PLA2G5, PTGIS, TBXAS1, PTGES2, PLA2G12A, PLA2G10, PLA2G12B, CYP4F2, PLA2G4C, CBR1, CBR3, PTGES, RAB10, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, SRC, HLA-A, HLA-B, HLA-C, HLA-DPB1, GPX5 |
| Arginine and proline metabolism | SAT2, HOGA1, L3HYPDH, AZIN2, CKB, CKMT2, ALDH2, ALDH9A1, ALDH3A2, AOC1, AMD1, GATM, GOT1, GOT2, P4HA3, PYCR2, OAT, ODC1, P4HA1, LAP3, SMOX, CNDP2, PYCR1, ALDH18A1, PRODH2, SAT1, PYCR3, SMS, SRM, AGMAT, CNDP1, ALDH4A1, P4HA2, RAF1, SRC, MYC, PIK3CA, PIK3CB, RAF1, BMI1 |
| Arginine biosynthesis | CPS1, GLS2, GLS, GLUD1, GLUD2, GLUL, GOT1, GOT2, GPT, ASL, ASS1, GPT2, JUN, RAP1A, SRC |
| Arrhythmogenic right ventricular cardiomyopathy | CACNG3, CACNG2, CTNNA1, CTNNA2, DAG1, DES, DMD, DSC2, DSG2, DSP, EMD, ITGA11, CACNG4, CTNNA3, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUP, ATP2A1, ATP2A2, ATP2A3, LEF1, PKP2, CACNA2D3, CACNG8, CACNG7, CACNG6, RYR2, SGCA, SGCB, SGCD, SLC8A2, SLC8A1, SLC8A3, TCF7, ACTG1, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, TCF7L1, ITGA10, ITGA8, ACTN2, ACTN3, CACNA2D2, CACNA2D4, CDH2, CTNNB1, GJA1, ITGA6, ITGA4, ITGA5, ITGAV, ITGB1, LAMA2, ACTB, TCF7L2, CACNA1S, CACNA2D1, LAMA2 |
| Ascorbate and aldarate metabolism | UGT2B11, UGT2A1, ALDH2, ALDH9A1, ALDH3A2, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, UGDH, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, RGN |
| Asthma | FCER1A, MS4A2, FCER1G, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IL3, IL13, PRG2, RNASE3, CCL11, TNF, EPX, CD40, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL4, IL5, IL10, TNF |
| Autoimmune thyroid disease | CTLA4, GZMB, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, IFNA2, IFNA8, IFNA10, IFNA14, TG, TPO, TSHB, TSHR, CD28, CD80, CD86, CD40, CGA, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, IFNA1, FAS, IL2, FASLG, IL4, IL5, IL10, PRF1 |
| Autophagy - animal | AKT3, TANK, RRAGB, CAMKK2, RRAGA, GABARAP, GABARAPL2, ATG4A, PRAP1, SMCR8, CTSB, CTSL, DAPK1, EIF2S1, C9orf72, AKT2, ERN1, RRAS2, MRAS, ATG2A, ATG4B, DAPK2, GABARAPL1, WIPI2, ATG9B, TBK1, NRBF2, PIK3R4, HMGB1, HRAS, IGBP1, INS, IRS1, ITPR1, KRAS, LAMP1, LAMP2, RAB8A, SH3GLB1, PDPK1, PIK3C3, PIK3CD, PIK3R1, PIK3R2, ZFYVE1, STX17, ATG16L1, WIPI1, ATG2B, PPP2CA, WDR41, SUPT20H, AMBRA1, PRKAA2, PRKACB, PRKACG, PRKCD, PRKCQ, MAPK9, MAPK10, MAP2K1, MAP2K2, RPTOR, RRAGD, RAB1A, BCL2L1, RHEB, ATG101, RPS6KB1, RPS6KB2, RRAS, MLST8, MTMR14, ATG3, DEPTOR, BNIP3, MAP3K7, TRAF6, TSC1, TSC2, UVRAG, RAB7A, ATG9A, VMP1, RAB33B, ATG10, ULK1, AKT1S1, IRS4, ATG4C, ATG4D, PIK3R3, IRS2, VAMP8, BECN1, CFLAR, SQSTM1, MTMR3, ATG16L2, MTMR4, ATG12, SNAP29, EIF2AK3, ATG5, ULK2, RUBCN, ATG13, RB1CC1, ATG7, CTSD, DAPK3, AKT1, MTOR, HIF1A, IGF1R, PIK3CA, PIK3CB, PPP2CB, PRKAA1, PRKACA, MAPK1, MAPK3, MAPK8, BAD, PTEN, RAF1, BCL2, STK11, ATG7, DAPK3, PIK3CB, PPP2CB, PRKAA1, PRKACA, STK11 |
| Autophagy - other | GABARAP, GABARAPL2, ATG4A, ATG2A, ATG4B, GABARAPL1, WIPI2, ATG9B, PIK3R4, IGBP1, PIK3C3, ATG16L1, WIPI1, ATG2B, PPP2CA, RPTOR, ATG101, MLST8, ATG3, ATG9A, ATG10, ATG4C, ATG4D, BECN1, ATG12, ATG5, ULK2, ATG13, ATG7, MTOR, PPP2CB, ATG7, PPP2CB |
| Axon guidance | PLXNC1, CDK5, PAK4, MYL12B, SEMA6C, SEMA6B, SEMA4D, SEMA4B, SEMA3C, MYL12A, CFL2, UNC5D, GDF7, DCC, DPYSL2, EFNA1, EFNA2, EFNA3, EFNA5, EFNB1, EFNB2, EFNB3, EPHA2, EPHA1, EPHA3, EPHA4, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, UNC5B, FES, NTNG1, ABLIM3, ARHGEF12, SRGAP2, PLXNB2, ABL1, NGEF, GNAI2, GNAI3, EPHA6, RHOD, HRAS, ILK, KRAS, L1CAM, ABLIM1, LIMK1, MYL5, NCK1, NFATC2, NFATC3, NFATC4, NTN3, PAK3, PARD6A, PDK1, PIK3CD, PIK3R1, PIK3R2, PLCG2, PLXNA1, PLXNA2, PLXNB1, PLXNB3, WNT4, SSH1, SEMA4C, SSH3, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PLXNA3, ENAH, PRKCZ, PARD3, DPYSL5, SEMA3G, PAK6, RGMA, PAK5, PTCH1, PTK2, SRGAP1, SEMA6A, SEMA4G, RAC1, RAC2, RAC3, RASA1, NTN4, ROBO1, ROBO2, ROCK1, RRAS, RYK, CXCL12, SEMA3F, LRRC4, ROBO3, SLIT1, SLIT3, SMO, TRPC1, TRPC3, TRPC4, TRPC5, CXCR4, SEMA3B, FZD3, SEMA6D, WNT5B, CAMK2A, CAMK2B, CAMK2D, CAMK2G, NCK2, ABLIM2, PARD6G, PARD6B, NTNG2, PIK3R3, SSH2, UNC5C, NRP1, UNC5A, SEMA5A, PLXNA4, SLIT2, NTN1, ROCK2, SEMA3E, SRGAP3, SEMA3A, CFL1, FYN, GNAI1, GSK3B, ITGB1 |
| B cell receptor signaling pathway | AKT3, LILRB2, VAV3, LILRB5, LILRB4, LILRA1, LILRB3, LILRA3, LILRA2, PIK3AP1, CR2, AKT2, FCGR2B, FOS, LILRA4, RASGRP3, DAPP1, GRB2, HRAS, LILRA5, IKBKB, INPP5D, KRAS, LYN, NFATC1, NFATC2, NFATC3, NFKBIA, NFKBIB, NFKBIE, PIK3CD, PIK3R1, PIK3R2, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB, MAP2K1, MAP2K2, PTPN6, RAC1, RAC2, RAC3, RELA, SOS2, SYK, BTK, VAV1, VAV2, LILRA6, CARD11, PIK3R3, IKBKG, IFITM1, BCL10, CD19, CD22, CD72, CD79B, CD81, MALT1, AKT1, GSK3B, JUN, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, RAF1, SOS1, CD79A, PIK3CB |
| Bacterial invasion of epithelial cells | ARPC5, ARPC4, ARPC3, ARPC1B, WASF2, MAD2L2, ARPC1A, SEPTIN9, CLTA, CLTB, CLTC, CRK, CRKL, CTNNA1, CTNNA2, SEPTIN1, DNM1, DOCK1, CTTN, SEPTIN8, CD2AP, GAB1, SHC2, DNM3, ARHGEF26, CTNNA3, HCLS1, ILK, RHOG, SHC4, SEPTIN2, PIK3CD, PIK3R1, PIK3R2, SHC3, SEPTIN11, SEPTIN3, PTK2, PXN, RAC1, ELMO2, SHC1, ACTG1, VCL, ARHGAP10, ELMO3, ARPC5L, CLTCL1, PIK3R3, CAV1, CAV2, CAV3, CBL, WASF1, BCAR1, ELMO1, ARPC2, SEPTIN12, CTNNB1, DNM2, FN1, ITGA5, ITGB1, RHOA, MET, PIK3CA, PIK3CB, ACTB, SRC, CAV1, WASL, CDC42, CDH1, ARPC2, RHOA, PIK3CB |
| Basal cell carcinoma | CDKN1A, APC2, DDB2, GADD45A, DVL1, DVL2, DVL3, FZD2, GLI1, GLI2, GLI3, APC, KIF7, GADD45B, LEF1, WNT16, POLK, SUFU, WNT4, PTCH1, HHIP, BMP2, SMO, TCF7, TP53, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, WNT5B, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, PTCH2, WNT3A, GADD45G, CTNNB1, GSK3B, BAK1, BAX, SHH, BMP4, TCF7L2, TP53, WNT5A, GADD45G |
| Basal transcription factors | CDK7, TAF6L, TAF5L, GTF2A1, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H3, GTF2H4, GTF2I, TBPL2, GTF2H5, MNAT1, TAF9B, TAF1, TAF2, TAF4, TAF5, TAF6, TAF7, TAF9, TAF10, TAF11, TAF12, TAF13, TAF15, TAF3, CCNH, GTF2IRD1, CGA, HSD3B1, HSD3B2, JUN, PIK3CA, PIK3CB |
| Base excision repair | PARP3, PARP4, FEN1, SMUG1, NEIL2, APEX2, POLL, HMGB1, LIG1, LIG3, MUTYH, NTHL1, POLE3, POLB, POLD1, POLD2, POLE, NEIL3, POLE4, POLD4, TDG, UNG, NEIL1, MBD4, MET, MYC, PIK3CA, PIK3CB, PLAU, PLAUR, RAF1, SRC, POLD3 |
| beta-Alanine metabolism | ABAT, DPYD, DPYS, ECHS1, ALDH2, ALDH1A3, ALDH3B1, ALDH3B2, ALDH9A1, ALDH3A2, MLYCD, GAD1, GAD2, HIBCH, HADHA, AOC2, GADL1, ACADS, ALDH6A1, ACOX1, UPB1, SMOX, CNDP2, ACOX3, CNDP1, AOC3 |
| Bile secretion | ABCC4, SLC22A7, SLC27A5, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, SLC51B, ADCY4, EPHX1, SLCO1B3, HMGCR, AQP1, AQP9, KCNN2, LDLR, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ABCB4, PRKACB, PRKACG, BAAT, NCEH1, SCT, SCTR, SLC4A2, SLC5A1, SLC9A1, SLC10A2, SLCO1A2, SLC22A1, UGT2B4, ABCB11, SLC4A4, ABCC3, SLC22A8, ABCG2, SCARB1, NR1H4, ADCY1, ADCY2, CFTR, ADCY3, GNAS, AQP8, AQP4, ABCB1, PRKACA, RXRA, SLC2A1, SLC9A3, SULT2A1, CA2, ADCY1, ADCY3, AQP4, PRKACA, RXRA, SLC2A1, SLC9A3 |
| Biosynthesis of amino acids | SDS, SDSL, CPS1, CS, CTH, ENO2, ENO3, PRPS1L1, ALDOA, ALDOB, RPIA, ALDOC, PHGDH, MAT2B, GLUL, GOT1, GOT2, GPT, PYCR2, IDH2, IDH3A, IDH3B, IDH3G, MAT1A, MAT2A, ASL, ASNS, ASS1, ACO1, ACO2, PAH, PC, PFKL, PFKM, PFKP, PGAM2, PKLR, PKM, PRPS1, PSPH, PYCR1, ALDH18A1, BCAT1, BCAT2, RPE, SHMT1, SHMT2, PYCR3, TALDO1, TAT, TKT, TPI1, TKTL1, TKTL2, GPT2, ENO1, GAPDH, PSAT1, IDH1, ARG2, ENO4, PGAM4, MTR, PGAM1, PGK1, PGK2, PRPS2, CBS, ENO4 |
| Biosynthesis of unsaturated fatty acids | ACOT2, ACOT7, ACOT4, HACD2, ACAA1, FADS1, ACOX1, HSD17B12, HACD3, ELOVL2, BAAT, ELOVL5, SCD, SCP2, ELOVL1, ELOVL4, ELOVL6, SCD5, ACOX3, ELOVL3, HACD1, FADS2, TECR, GAA |
| Biotin metabolism | HLCS, OXSM, BTD |
| Bladder cancer | CDKN1A, DAPK1, HBEGF, E2F2, E2F3, TYMP, DAPK2, HRAS, KRAS, MAP2K1, MAP2K2, CCND1, BRAF, THBS1, TP53, UPK3A, RPS6KA5, CDKN2A, RASSF1, DAPK3, E2F1, EGF, EGFR, ERBB2, FGFR3, CXCL8, MDM2, MMP2, MMP9, MYC, MAPK1, MAPK3, RAF1, RB1, SRC, TP53, VEGFA, CDH1, DAPK3 |
| Breast cancer | AKT3, CDK6, CDKN1A, APC2, DLL3, CSNK1A1L, CSNK1A1, DDB2, GADD45A, JAG1, DVL1, DVL2, DVL3, E2F2, E2F3, AKT2, ESR1, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FLT4, FRAT2, HEY1, HEY2, FOS, FZD2, SHC2, FGF20, FGF21, FGF22, DLL1, GRB2, APC, HRAS, HES1, JAG2, KRAS, SHC4, LRP6, LRP5, GADD45B, NFKB2, NOTCH1, NOTCH3, NOTCH4, LEF1, WNT16, POLK, PIK3CD, PIK3R1, PIK3R2, SHC3, WNT4, MAP2K1, MAP2K2, CCND1, RPS6KB1, RPS6KB2, SHC1, SOS2, BRAF, TCF7, TP53, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, FGF23, WNT5B, NCOA3, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, PIK3R3, NCOA1, FGF18, WNT3A, FGF19, GADD45G, CTNNB1, E2F1, EGF, EGFR, ERBB2, AKT1, ESR1, ESR2, FGF3, FGF4, FGF8, FGF9, FGFR1, MTOR, GSK3B, IGF1, IGF1R, JUN, KIT, MYC, PGR, PIK3CA, PIK3CB, MAPK1, MAPK3, PTEN, BAK1, BAX, RAF1, RB1, SOS1, SP1, BRCA1, BRCA2, TCF7L2, TP53, WNT5A, FGF17, GADD45G, FGF4, PIK3CB |
| Butanoate metabolism | ACSM1, ACSM2A, ABAT, ECHS1, GAD1, GAD2, HADHA, HADH, HMGCL, HMGCS1, HMGCS2, ACADS, OXCT1, HMGCLL1, ACSM5, BDH2, BDH1, ACSM3, OXCT2, AACS, ALDH5A1, L2HGDH, RAF1 |
| C-type lectin receptor signaling pathway | AKT3, IRF9, NLRP3, PLK3, CYLD, CALML6, EGR2, EGR3, AKT2, FCER1G, RRAS2, MRAS, ARHGEF12, PYCARD, CD209, HRAS, CLEC4D, IKBKB, IRF1, ITPR1, ITPR2, ITPR3, KRAS, LSP1, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIA, CLEC1B, CALML5, PIK3CD, PIK3R1, PIK3R2, IL17D, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCD, MAPK11, MAPK9, MAPK10, MAPK13, RELA, RELB, BCL3, RRAS, MAPK12, CCL17, CCL22, CARD9, STAT2, SYK, TNF, CALM2, CALM3, CALML3, PIK3R3, IKBKG, CBLB, KSR1, BCL10, MAP3K14, CALML4, CLEC6A, IKBKE, MALT1, MAPK14, AKT1, IL1B, IL2, IL6, IL10, IL12A, JUN, RHOA, MDM2, NFKB1, PAK1, IL23A, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, PTGS2, PTPN11, RAF1, CLEC7A, SRC, STAT1, TNF, CALM1, CASP1, CASP8, MAPKAPK2, RHOA, PIK3CB, CALM1, MAPKAPK2 |
| Caffeine metabolism | CYP2A6, RAF1, PIK3CA, PIK3CB |
| Calcium signaling pathway | PPIF, TRDN, CYSLTR1, CHRM1, CHRM2, ADCY7, CHRM3, CHRM5, CHRNA7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1D, ADRA1B, ADRA1A, ADRB1, ADRB2, ADRB3, CALML6, DRD1, AGTR1, EDNRB, ADCY4, ERBB3, PTK2B, TPCN2, P2RX2, GNA11, GNA15, GNAL, GNAQ, GRIN1, GRIN2A, GRIN2C, GRIN2D, SLC25A4, GRM1, GRM5, SLC25A5, SLC25A6, HRH1, HRC, HRH2, HTR2B, HTR2C, HTR5A, HTR6, HTR7, MYLK4, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, ASPH, MYLK, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, NTSR1, P2RX3, P2RX4, P2RX5, P2RX7, PLCE1, PDE1A, PDE1C, PDE1B, PDGFRA, PDGFRB, CALML5, PHKA2, PHKB, PHKG1, PHKG2, PLCB2, PLCB3, PLCD1, PLCG2, TPCN1, PLN, AVPR1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PRKCB, PRKCG, LTB4R2, SPHK2, CAMK1D, PTAFR, PTGER1, PTGER3, STIM2, BDKRB1, BDKRB2, RYR1, RYR2, SLC8A2, SLC8A1, SLC8A3, STIM1, TACR2, TBXA2R, VDAC2, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CXCR4, ORAI2, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, SLC25A31, CASQ1, CASQ2, PLCD4, CAMK1, MYLK2, CCKAR, CACNA1I, CACNA1H, CACNA1G, P2RX6, MYLK3, |
| cAMP signaling pathway | AKT3, HCN4, ABCC4, RAPGEF3, VAV3, CREB3, PDE10A, RAPGEF4, ADCY5, ADCY6, CHRM1, CHRM2, ADCY7, ADCY8, ADCY9, GRIN3A, GRIN3B, ADCYAP1R1, CNGB1, CNGA2, ADORA2A, CREBBP, GPR119, ADRB1, ADRB2, CALML6, DRD1, DRD2, EDN1, EDN3, ADCY4, EP300, AKT2, RRAS2, FOS, GABBR1, GHSR, GIPR, HCAR1, GLI1, GLI3, GLP1R, GNAI2, GNAI3, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, HTR1B, HTR1E, HTR6, HCAR2, MC2R, AFDN, PPP1R12A, ATP1A1, ATP1A2, NFATC1, ATP1A3, NFKBIA, ATP1A4, ATP1B1, ATP1B2, ATP1B3, NPY, FXYD2, ATP2A1, ATP2A2, NPR1, NPY1R, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ACOX1, PLCE1, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, CALML5, PIK3CD, PIK3R1, PIK3R2, PLD1, PLD2, FXYD1, PLN, POMC, PPARA, CNGB3, PPP1CB, PRKACB, PRKACG, MAPK9, MAPK10, MAP2K1, MAP2K2, SUCNR1, PTCH1, PTGER2, PTGER3, RAC1, RAC2, RAC3, RAP1B, RELA, ROCK1, HCN2, RRAS, RYR2, HHIP, ARAP3, CREB3L2, SLC9A1, BRAF, SST, SSTR5, TIAM1, TSHB, TSHR, VAV1, VAV2, VIPR2, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, ACOX3, PPP1R1B, CREB3L3, PI |
| Carbohydrate digestion and absorption | AKT3, AKT2, SLC37A4, HK2, HK3, LCT, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PRKCB, G6PC2, SI, SLC2A5, SLC5A1, CACNA1D, HKDC1, TAS1R2, TAS1R3, PIK3R3, MGAM, MGAM2, AKT1, PLCB1, AMY1A, AMY2A, HK1, PIK3CA, PIK3CB, G6PC3, AMY1A, HK1, PIK3CB |
| Carbon metabolism | ME3, SDS, SDSL, ADH5, GLYCTK, CPS1, CS, DLAT, DLST, AGXT, ECHS1, ENO2, ENO3, ESD, FBP1, PRPS1L1, ALDOA, FH, ALDOB, RPIA, ALDOC, PGLS, TKFC, PHGDH, HIBCH, GCK, GCSH, GLDC, GLUD1, GLUD2, AMT, GOT1, GOT2, GPI, PGP, GPT, HADHA, HK2, HK3, IDH2, IDH3A, IDH3B, IDH3G, ACADS, IDNK, MDH1, MDH2, ME1, ME2, ALDH6A1, ACO1, OGDH, ACO2, PC, PCCA, PCCB, ACOX1, HAO2, PDHA1, PDHB, PFKL, PFKM, PFKP, PGAM2, PGD, PKLR, PKM, HAO1, OGDHL, ACSS2, PRPS1, PSPH, RPE, SDHC, SDHD, SHMT1, SHMT2, TALDO1, TKT, TPI1, HKDC1, TKTL1, ACOX3, ADPGK, TKTL2, ACSS1, MCEE, GPT2, FBP2, SUCLG2, SUCLG1, SUCLA2, RGN, H6PD, DLD, ENO1, G6PD, GAPDH, PSAT1, HK1, IDH1, ACAT1, ENO4, PGAM4, MTHFR, PDHA2, PGAM1, PGK1, PGK2, PRPS2, SDHA, SDHB, CAT, DLD, HK1, ENO4, PDHA2 |
| Cardiac muscle contraction | TRDN, CACNG3, CACNG2, SLC9A6, UQCR11, COX6B2, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, CYC1, COX7B2, UQCRQ, CACNG4, UQCR10, HRC, COX8C, UQCRHL, ASPH, COX2, MYH6, MYL2, MYL3, MYL4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2A1, ATP2A2, ATP2A3, CACNA2D3, CACNG8, CACNG7, CACNG6, RYR2, SLC8A2, SLC8A1, SLC8A3, SLC9A1, ACTC1, TPM2, TPM3, TPM4, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CASQ2, SLC9A7, COX7A2L, CACNA2D2, CACNA2D4, COX5A, COX1, COX3, CYTB, MYH7, TPM1, CACNA1S, CACNA2D1 |
| CCKR signaling map | HBEGF, IEX1, TFF2, CXCL2, FOS, FOS, FOS, FOS, CXCL1, PAI2, PAI2, PAI2, CCND1, CCND1, CCND1, CCND1, CALCA, ODC1, MOB1, MOB1, TFF1, NR4A1, VMAT2, VMAT2, HBEGF, HBEGF, IEX1, TFF2, CXCL2, FOS, FOS, CXCL1, PAI2, PAI2, PAI2, BIRC2, CCND1, CCND1, CCND1, CCND1, CALCA, MOB1, MOB1, TFF1, NR4A1, VMAT2, VMAT2, MAPK7, MAPK7, CCK-22, HBEGF, HBEGF, HBEGF, Carboxypeptidase E, CNKSR1, p70S6K1, p70S6K1, MEF2, ROCK1, CaMKK, CaMKK, FOS, 14-3-3 beta/alpha, RGS2, SP3, SP3, CCK-33, MEF2D, CK1, IKBalpha, IKBalpha, PKCepsilon, PKCepsilon, PKCepsilon, B-Raf, B-Raf, CCK-G, MAP3K14, MAP3K14, AP2M1, AP2M1, AP2M1, AP2M1, PKCeta, PKCeta, CSK, FOXO3, MAP2K4, MAP2K4, PRAS40, CCK, CCK, ATF2, SHC1 @EGFR, MEN1, MEN1, MEN1, PLA2, PLA2, PLA2, PLA2, PLA2, PLA2, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, RYR1/2/3, CK1delta/epsilon, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, MAPK8-10, IEX1, EIF4E, EIF4E, SAP1, p46 SHC |
| Cell adhesion molecules | CDH3, CDH4, CDH5, CDH15, CD226, CLDN16, CNTN1, CLDN4, CLDN7, CLDN23, CTLA4, ALCAM, NLGN4Y, NTNG1, NFASC, ICOSLG, CLDN14, CLDN15, NEGR1, CNTNAP2, CLDN17, GLG1, CD274, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, ICAM3, ITGA9, ITGAL, ITGAM, ITGB2, ITGB7, ITGB8, L1CAM, MAG, MPZ, NCAM2, NRCAM, F11R, CLDN18, PECAM1, NLGN4X, NLGN2, CADM3, PTPRC, PTPRF, PTPRM, PVR, NECTIN1, JAM2, SDC1, SDC2, SDC4, SELL, SELP, SELPLG, LRRC4, VSIR, SIGLEC1, SPN, CNTN2, CLDN5, VCAM1, VTCN1, PDCD1LG2, MADCAM1, CD99L2, JAM3, NTNG2, CNTNAP1, ITGA8, MPZL1, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, ESAM, CD2, CD4, CD6, CD8B, CD22, NRXN3, NRXN1, NRXN2, CD28, LRRC4B, CD80, CD86, CD34, CD40, CD58, SDC3, CDH2, IGSF11, NLGN1, CADM1, NECTIN3, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, ICAM1, ICAM2, ITGA6, ITGA4, ITGAV, ITGB1, CD99, NCAM1, CLDN11, PDCD1, LRRC4C, NECTIN2, CD8A, CDH1, IGSF11, NLGN1, ICAM2, NECTIN2 |
| Cell cycle | CDK6, CDK7, CDKN1A, CDKN1B, STAG1, CDKN1C, CDKN2B, CDKN2C, CDKN2D, MAD2L2, STAG2, PTTG2, DBF4, CREBBP, GADD45A, E2F2, E2F3, E2F4, E2F5, EP300, ORC3, CDC26, ABL1, ANAPC13, SFN, ANAPC2, ANAPC4, HDAC2, MAD2L1, SMAD2, SMAD3, SMAD4, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, GADD45B, ORC1, ORC2, ORC4, ORC5, FZR1, ANAPC5, ANAPC7, ANAPC11, PLK1, PRKDC, RAD21, RBL1, RBL2, CCND1, ANAPC1, SKP1, SKP2, BUB1, BUB1B, TFDP1, TFDP2, TGFB2, TP53, TTK, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, ZBTB17, SMC1A, CDC45, MAD1L1, CUL1, CCNB3, CDC14B, CDC23, CDC16, CCND3, CCNE1, CCNH, PKMYT1, SMC3, CCNE2, BUB3, ESPL1, CDC6, CDC25B, CDC27, RBX1, CDK2, CDKN2A, GADD45G, YWHAQ, CHEK1, CHEK2, E2F1, SMC1B, GSK3B, HDAC1, MDM2, MYC, ATM, PCNA, ATR, RB1, TGFB1, TGFB3, TP53, WEE1, CDC7, CDC14A, CCNA2, CCNA1, CCNB1, CCND2, CCNB2, PTTG1, CDK1, CDC20, CDC25A, CDC25C, GADD45G, CHEK1, SMC1B, CCND2 |
| Cellular senescence | AKT3, RAD50, HIPK3, CDK6, CDKN1A, CDKN2B, TRAF3IP2, LIN54, RAD9B, HIPK4, CALML6, GADD45A, E2F2, E2F3, E2F4, E2F5, EIF4EBP1, HIPK1, AKT2, ETS1, RRAS2, MRAS, FOXO3, FBXW11, LIN9, HIPK2, SLC25A4, SLC25A5, SLC25A6, HLA-F, HRAS, HUS1, ITPR1, ITPR2, ITPR3, KIR2DL1, KRAS, SMAD2, SMAD3, MRE11, GADD45B, NFATC1, NFATC2, NFATC3, NFATC4, CALML5, PIK3CD, PIK3R1, PIK3R2, PPID, PPP1CB, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, LIN37, MAPK11, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, RAD1, RAD9A, RBBP4, RBL1, RBL2, CCND1, RELA, RHEB, RRAS, MAPK12, ZFP36L1, ZFP36L2, TGFB2, TGFBR1, TGFBR2, TP53, TSC1, TSC2, VDAC2, CACNA1D, CALM2, CALM3, CALML3, CAPN1, CAPN2, SLC25A31, RASSF5, PIK3R3, CCNB3, SQSTM1, BTRC, CCND3, CCNE1, CCNE2, LIN52, CALML4, CDK2, CDKN2A, GADD45G, CHEK1, CHEK2, MAPK14, E2F1, AKT1, FOXM1, FOXO1, SIRT1, MTOR, GATA4, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, IGFBP3, IL1A, IL6, CXCL8, KIR2DL2, MDM2, MYBL2, MYC, NBN, ATM, NFKB1, SERPINE1, PIK3CA, PIK3CB, ATR, PPP1CC, MAPK1, MAPK3, PTEN, RAF1, RB1, TRPV4, TGFB1, TGFB3, TP53, VDA |
| Central carbon metabolism in cancer | AKT3, AKT2, GCK, GLS2, GLS, HK2, HK3, HRAS, KRAS, LDHB, SIRT6, PDGFRA, PDGFRB, PDHA1, PDHB, PDK1, PFKL, PFKM, PFKP, PGAM2, PIK3CD, PIK3R1, PIK3R2, PKM, MAP2K1, MAP2K2, TIGAR, RET, SLC1A5, TP53, HKDC1, PIK3R3, LDHAL6B, SCO2, EGFR, ERBB2, AKT1, FGFR1, FGFR3, FGFR2, FLT3, SIRT3, MTOR, G6PD, HIF1A, HK1, IDH1, KIT, LDHA, LDHC, MET, PGAM4, MYC, NTRK1, NTRK3, PDHA2, PGAM1, PIK3CA, PIK3CB, MAPK1, MAPK3, PTEN, RAF1, SLC2A1, TP53, SLC7A5, HK1, NTRK3, PDHA2, PIK3CB, SLC2A1 |
| cGMP-PKG signaling pathway | AKT3, PPIF, IRAG1, CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CNGB1, ATF2, ATF6B, ADORA3, ADRA1D, PIK3R6, ADRA1B, ADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CALML6, AGTR1, EDNRB, ADCY4, AKT2, PIK3R5, KCNMB3, KCNMB4, GNA11, GNA12, GNAI2, GNAI3, GNAQ, SLC25A4, SLC25A5, SLC25A6, GTF2I, GUCY1A2, GUCY1A1, GUCY1B1, MYLK4, INS, IRS1, ITPR1, ITPR2, ITPR3, KCNJ8, KCNMA1, KCNMB1, BORCS8-MEF2B, MEF2C, MEF2D, MYH6, MYLK, PPP1R12A, ATF4, ATP1A1, ATP1A2, NFATC1, NFATC2, NFATC3, NFATC4, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2A1, ATP2A2, NPPC, NPR1, NPR2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, OPRD1, PDE2A, PDE3A, PDE3B, CALML5, PIK3CG, PLCB2, PLCB3, PLN, PPP1CB, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCE, PRKG1, MAP2K1, MAP2K2, RGS2, ROCK1, BDKRB2, CREB3L2, SLC8A2, SLC8A1, SLC8A3, SRF, VASP, VDAC2, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, SLC25A31, CREB3L3, IRS4, MYLK2, PDE5A, IRS2, MYLK3, CALML4, ROCK2, GTF2IRD1, CREB5, GNA13, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, KCNU1, EDNRA, AKT1, PLCB1, GATA4, GNAI1, INS |
| Chagas disease | AKT3, TLR6, TICAM1, AKT2, FOS, GNA11, GNA15, GNAI2, GNAI3, GNAL, GNAQ, IFNGR1, IFNGR2, IKBKB, IRAK1, SMAD2, CCL3L3, MYD88, NFKBIA, IRAK4, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, TLR9, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, MAPK11, MAPK9, MAPK10, MAPK13, RELA, BDKRB2, MAPK12, CCL2, CCL3, MAP2K4, TGFB2, TGFBR1, TGFBR2, C1QA, TNF, C1QB, C1QC, TRAF6, CALR, PIK3R3, IKBKG, FADD, CFLAR, CD3E, CD3G, CD247, GNA14, ADCY1, MAPK14, TICAM1, ACE, AKT1, PLCB1, GNAI1, GNAO1, GNAS, IFNG, FAS, IL1B, IL2, FASLG, IL6, CXCL8, IL10, IL12A, JUN, NFKB1, NOS2, SERPINE1, PIK3CA, PIK3CB, PPP2CB, MAPK1, MAPK3, MAPK8, CCL5, TGFB1, TGFB3, TLR2, TLR4, TNF, TNFRSF1A, C3, CASP8, ADCY1, TICAM1, PIK3CB, PPP2CB |
| Chemical carcinogenesis | UGT2B11, UGT2A1, CHRNA7, GSTO2, ADH1A, ADH1B, ADH4, ADH5, ADH6, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2C18, CYP2E1, CYP3A5, AKR1C2, EPHX1, ALDH1A3, ALDH3B1, ALDH3B2, HPGDS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, HSD11B1, HSD11B1L, MGST2, MGST3, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, CYP3A43, SULT1A2, SULT1A3, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, CBR1, KYAT1, NAT1, GSTO1, NAT2, CYP1A1, CYP1A2, CYP1B1, GSTM1, GSTM3, GSTP1, GSTT1, GSTK1, MGST1, PTGS2, SULT1A1, SULT2A1, GSTM3 |
| Chemokine signaling pathway | AKT3, RASGRP2, CCL26, VAV3, CXCR6, GNB5, CCL27, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CCR1, CCR3, CCR4, CCR6, CCR7, GRK7, CRK, CRKL, PIK3R6, CX3CR1, GRK2, GRK3, DOCK2, ADCY4, AKT2, PTK2B, FGR, FOXO3, PIK3R5, SHC2, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, CCR10, XCR1, CXCR3, GRK4, GRK5, GRK6, GRB2, CXCL1, CXCL2, CXCL3, HCK, HRAS, IKBKB, CXCR1, CXCR2, CXCL10, ITK, JAK2, JAK3, KRAS, SHC4, LYN, ARRB2, CCL3L3, NFKBIA, NFKBIB, GNG13, PF4, PF4V1, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PLCB2, PLCB3, SHC3, GNG2, PPBP, PRKACB, PRKACG, PRKCB, PRKCD, PRKCZ, GNG12, MAP2K1, PARD3, CCL28, PTK2, PREX1, CXCL16, PXN, RAC1, RAC2, RAC3, RAP1B, GNB4, RELA, GRK1, ROCK1, CCL1, CCL2, CCL3, CCL7, CCL8, CCL11, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CXCL6, CXCL11, CXCL5, CXCL12, CXCR5, SHC1, NCF1, SOS2, BRAF, STAT2, STAT5B, TIAM1, VAV1, VAV2, WAS, CXCR4, PIK3R3, IKBKG, GNG8, ROCK2, CXCL14, BCAR1, ELMO1, ADCY1, ADCY2, ADCY3, CCR5, AKT1, PLCB1, GNAI1, GSK3A, GSK3B, CXCL8, RH |
| Cholesterol metabolism | CETP, STARD3, OSBPL5, PCSK9, ANGPTL3, MYLIP, APOA1, APOA4, APOC1, APOC3, APOH, LCAT, LDLR, LIPA, LIPC, LPL, LRP1, LRP2, LRPAP1, NPC1, ANGPTL4, ANGPTL8, NCEH1, SORT1, SOAT1, STAR, VDAC2, ABCB11, VAPB, VAPA, LIPG, CD36, SCARB1, NPC2, ABCA1, APOB, APOE, PLTP, TSPO, VDAC1, VDAC2, VDAC3, PLTP, TSPO, VDAC3 |
| Choline metabolism in cancer | AKT3, WASF2, LYPLA1, WASF3, SLC44A3, DGKK, DGKA, DGKB, DGKG, DGKH, DGKQ, EIF4EBP1, SLC44A5, AKT2, PIP5K1C, SLC44A1, FOS, GRB2, HRAS, KRAS, PCYT1A, PDGFA, PDGFB, PDGFRA, PDGFRB, PDPK1, PIK3CD, PIK3R1, PIK3R2, PLA2G4A, PLD1, PLD2, PRKCB, PRKCG, MAPK9, MAPK10, PDGFC, MAP2K1, MAP2K2, GPCPD1, CHPT1, SLC44A2, RAC1, RAC2, RAC3, RALGDS, RHEB, SLC5A7, RPS6KB1, RPS6KB2, SLC22A1, SLC22A3, SLC22A2, SLC22A4, SOS2, TSC1, TSC2, WAS, PDGFD, SLC44A4, PIP5K1A, PIP5K1B, PIK3R3, DGKZ, DGKE, DGKD, PLA2G4C, PLPP1, PLPP2, PLPP3, WASF1, DGKI, PCYT1B, CHKA, EGF, EGFR, AKT1, MTOR, HIF1A, JUN, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, MAPK8, RAF1, SLC22A5, SOS1, SP1, PIK3CB, PLCG1, PRKCA |
| Cholinergic synapse | AKT3, CREB3, GNB5, CHAT, ADCY5, ADCY6, CHRM1, CHRM2, ADCY7, CHRM3, CHRM4, CHRM5, CHRNA3, CHRNA4, CHRNA7, ADCY8, CHRNB2, CHRNB4, ADCY9, PIK3R6, ADCY4, AKT2, FOS, PIK3R5, GNA11, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, HRAS, ITPR1, ITPR2, ITPR3, JAK2, KCNJ2, KCNJ4, KCNJ12, KCNQ2, KCNQ3, KRAS, ATF4, GNG13, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PLCB2, PLCB3, GNG2, PRKACB, PRKACG, PRKCB, PRKCG, GNG12, MAP2K1, KCNQ5, GNB4, SLC5A7, CREB3L2, SLC18A3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB3L3, PIK3R3, CHRNA6, KCNQ4, GNG8, CREB5, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, AKT1, PLCB1, FYN, GNAI1, GNAO1, KCNJ6, KCNQ1, ACHE, PIK3CA, PIK3CB, PRKACA, PRKCA, MAPK1, MAPK3, BCL2, CACNA1S, CAMK4, ADCY1, ADCY3, CREB1, CREB3L4, KCNJ6, KCNQ1, ACHE, PIK3CB, PRKACA, PRKCA |
| Chronic myeloid leukemia | AKT3, CDK6, CDKN1A, CDKN1B, CRK, CRKL, CTBP1, CTBP2, DDB2, GADD45A, E2F2, E2F3, AKT2, MECOM, ABL1, SHC2, GRB2, HDAC2, HRAS, IKBKB, KRAS, SHC4, SMAD3, SMAD4, GADD45B, NFKBIA, POLK, PIK3CD, PIK3R1, PIK3R2, SHC3, MAP2K1, MAP2K2, CCND1, RELA, BCL2L1, BCR, SHC1, SOS2, BRAF, STAT5A, STAT5B, TGFB2, TGFBR1, TGFBR2, TP53, PIK3R3, IKBKG, RUNX1, CBL, GAB2, CDKN2A, GADD45G, E2F1, AKT1, HDAC1, MDM2, MYC, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, BAD, BAK1, PTPN11, BAX, RAF1, RB1, SOS1, TGFB1, TGFB3, TP53, GADD45G, PIK3CB |
| Circadian entrainment | GNB5, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCYAP1R1, CALML6, ADCY4, FOS, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GUCY1A2, GUCY1A1, GUCY1B1, ITPR1, ITPR3, KCNJ9, MTNR1A, GNG13, CALML5, PER1, PLCB2, PLCB3, GNG2, PRKACB, PRKACG, PRKCB, PRKCG, PRKG1, GNG12, GNB4, RYR1, RYR2, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PER3, PER2, CACNA1I, CACNA1H, CACNA1G, CALML4, RPS6KA5, GNG8, NOS1AP, ADCY1, ADCY2, ADCY3, ADCYAP1, CREB1, PLCB1, GNAI1, GNAO1, GNAS, KCNJ5, KCNJ6, PRKACA, PRKCA, ADCY10, MAPK1, MAPK3, RYR3, CALM1, ADCY1, ADCY3, CREB1, KCNJ5, KCNJ6, PRKACA, PRKCA, RYR3, CALM1 |
| Circadian rhythm | CRY1, CRY2, CSNK1D, CSNK1E, FBXW11, FBXL3, ARNTL, PRKAG2, PER1, PRKAA2, PRKAB1, RORA, RORB, RORC, SKP1, BHLHE41, CUL1, BHLHE40, PER3, PER2, BTRC, NR1D1, RBX1, CREB1, NPAS2, PRKAA1, CLOCK, CREB1, PRKAA1 |
| Citrate cycle | CS, DLAT, DLST, FH, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, ACLY, ACO1, OGDH, ACO2, PC, PCK2, PDHA1, PDHB, OGDHL, SDHC, SDHD, SUCLG2, SUCLG1, SUCLA2, MGAT1, KIT, MET, PIK3CA, PIK3CB, DLD, PDHA2 |
| Cocaine addiction | CDK5, CREB3, ADCY5, GRIN3A, GRIN3B, ATF2, ATF6B, DDC, DLG4, DRD1, DRD2, FOSB, GPSM1, GNAI2, GNAI3, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM2, GRM3, ATF4, PDYN, PRKACB, PRKACG, RELA, CREB3L2, SLC6A3, SLC18A2, TH, PPP1R1B, CREB3L3, RGS9, CDK5R1, CREB5, CREB1, CREB3L4, GNAI1, GNAS, JUN, MAOA, NFKB1, PRKACA, BDNF, SLC18A1, CREB1, CREB3L4, PRKACA, SLC18A1 |
| Collecting duct acid secretion | TCIRG1, SLC12A7, CLCNKB, ATP6V1G3, ATP6V0E2, ATP6V1C2, ATP4A, ATP4B, ATP6V0A4, ATP6V1D, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V1G2, ATP6V0A1, SLC4A1, ATP6V0E1, ATP6V1E2, ATP6V0D1, ATP6V1F, ATP6V1G1, ATP6V0A2, CA2 |
| Colorectal cancer | AKT3, BCL2L11, CDKN1A, APC2, DCC, DDB2, GADD45A, EREG, AKT2, FOS, APPL1, BBC3, GRB2, MSH6, APC, HRAS, AREG, KRAS, SMAD2, SMAD3, SMAD4, GADD45B, LEF1, POLK, PIK3CD, PIK3R1, PIK3R2, MAPK9, MAPK10, MAP2K1, MAP2K2, RAC1, RAC2, RAC3, RALA, RALB, RALGDS, CCND1, RPS6KB1, RPS6KB2, SOS2, BRAF, TCF7, TGFA, TGFB2, TGFBR1, TGFBR2, TP53, AXIN1, AXIN2, TCF7L1, PIK3R3, GADD45G, CTNNB1, EGF, EGFR, AKT1, MTOR, GSK3B, BIRC5, JUN, RHOA, MLH1, MSH2, MYC, PIK3CA, PIK3CB, CYCS, MAPK1, MAPK3, MAPK8, BAD, BAK1, BAX, RAF1, BCL2, SOS1, TCF7L2, TGFB1, TGFB3, TP53, CASP3, CASP9, GADD45G, RHOA, PIK3CB, TGFA |
| Complement and coagulation cascades | PROCR, MASP2, CFHR3, VSIG4, CR1L, CR2, CD55, CFD, F2, F2RL2, F7, F8, F12, FGA, FGB, FGG, CFH, CFHR1, CFI, ITGAM, ITGAX, ITGB2, MBL2, SERPINB2, SERPINA1, PLG, SERPINF2, PROC, PROS1, MASP1, BDKRB1, BDKRB2, CFB, TFPI, THBD, SERPING1, C1QA, C1QB, C1QC, C1R, C1S, C2, C3AR1, C4BPB, C5, C5AR1, C6, C7, C8G, VTN, CFHR5, F2RL3, CD59, CLU, A2M, F2R, F3, F5, F10, CD46, SERPINC1, SERPINE1, SERPINA5, SERPINA1, PLAT, PLAU, PLAUR, C3, VWF |
| Cortisol synthesis and secretion | CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, AGT, AGTR1, ADCY4, GNA11, GNAQ, NR4A1, ITPR1, ITPR2, ITPR3, KCNA4, KCNK2, KCNK3, LDLR, MC2R, ATF4, PBX1, PDE8A, PLCB2, PLCB3, POMC, PRKACB, PRKACG, NCEH1, CREB3L2, STAR, CACNA1C, CACNA1D, CREB3L3, PDE8B, CACNA1I, CACNA1H, CACNA1G, SCARB1, CREB5, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CYP11A1, CYP11B1, CYP17A1, CYP21A2, NR0B1, PLCB1, NR5A1, GNAS, HSD3B1, HSD3B2, PRKACA, SP1, CACNA1S, ADCY1, ADCY3, CREB1, CREB3L4, PRKACA |
| Cushing syndrome | CDK6, CDKN1A, CDKN1B, APC2, CDKN2B, CDKN2C, CREB3, WDR5, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, CRH, CRHR1, CRHR2, AGT, AGTR1, DVL1, DVL2, DVL3, E2F2, E2F3, ADCY4, FH, AIPL1, FZD2, GNA11, GNAI2, GNAI3, GNAQ, NR4A1, APC, ITPR1, ITPR2, ITPR3, KCNA4, KCNK2, KCNK3, LDLR, MC2R, MEN1, KMT2A, ATF4, PBX1, PDE11A, LEF1, WNT16, PDE8A, PLCB2, PLCB3, WNT4, POMC, PRKACB, PRKACG, MAP2K1, MAP2K2, NCEH1, RAP1B, RBBP5, CCND1, CREB3L2, BRAF, STAR, TCF7, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, CACNA1C, CACNA1D, FZD5, FZD3, ARMC5, WNT10A, KMT2D, WNT5B, CAMK2A, CAMK2B, CAMK2D, CAMK2G, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, CREB3L3, PDE8B, CACNA1I, CACNA1H, CACNA1G, WNT3A, CCNE1, AIP, ASH2L, CCNE2, SCARB1, CREB5, CDK2, CDKN2A, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CTNNB1, CYP11A1, CYP11B1, CYP17A1, CYP21A2, E2F1, EGFR, AHR, PLCB1, NR5A1, GNAI1, GNAS, GSK3B, HSD3B1, HSD3B2, PRKACA, MAPK1, MAPK3, RAP1A, RB1, SP1, TCF7L2, WNT5A, CACNA1S, USP8, ADCY1, ADCY3, CREB1, CREB3L4, PRKAC |
| Cysteine and methionine metabolism | CDO1, AHCYL1, SDS, SDSL, CTH, AHCY, AHCYL2, BHMT2, AMD1, PHGDH, GCLC, MAT2B, GOT1, GOT2, LDHB, MAT1A, MAT2A, MDH1, MDH2, MPST, MTAP, APIP, ADI1, ENOPH1, BCAT1, BCAT2, SMS, SRM, TAT, TST, MRI1, KYAT1, LDHAL6B, HLA-C, HLA-E, HLA-G, KIR2DL2, MYC, PIK3CA, PIK3CB, RAF1, FYN, IL4I1 |
| Cytokine-cytokine receptor interaction | GDF11, CCL26, CXCR6, TNFSF13B, CCL27, EDAR, IL24, IL17F, TNFRSF13C, CCR1, CCR3, CCR4, CCR6, CCR7, CNTF, CNTFR, ACVR1C, IL31RA, CSF1R, CSF2RB, CSF3, CSF3R, CSH1, CSH2, IL34, CTF1, IL23R, GDF7, CX3CR1, EDA, EPO, EPOR, TNFRSF13B, CLCF1, IL17RA, IL27, IL36RN, GDF1, GDF2, MSTN, GH2, GHR, IL17C, TNFRSF21, CCR10, IFNL3, IFNL1, XCR1, CXCR3, CXCL1, CXCL2, CXCL3, IL19, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, IFNW1, IL1R1, IL1RAP, IL2RB, IL2RG, IL3, IL4R, IL5RA, IL7, IL7R, CXCR1, CXCR2, IL9R, IL10RA, IL10RB, IL11RA, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL16, TNFRSF9, INHBC, CXCL10, LIFR, LTA, LTB, LTBR, CCL3L3, MPL, NGFR, TNFRSF11B, OSM, IL20, IL21R, TNFRSF12A, ACKR4, PF4, PF4V1, IL17D, IL20RB, PPBP, TNFRSF19, IL26, IL36G, CCL28, ACKR3, CXCL16, IL22RA1, EDA2R, TNFRSF17, CCL1, CCL2, CCL3, CCL7, CCL8, CCL11, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CXCL6, CXCL11, CXCL5, CXCL12, CRLF2, CXCR5, IL25, BMP2, BMP5, BMP6, BMPR1A, TGFB2, TGFBR1, TGFBR2, THPO, TNF, TNFS |
| Cytosolic DNA-sensing pathway | ADAR, POLR3F, POLR3C, RIPK3, POLR3A, TREX1, CGAS, POLR3H, PYCARD, TBK1, STING1, IFNA2, IFNA8, IFNA10, IFNA14, IKBKB, CXCL10, IRF3, IRF7, NFKBIA, NFKBIB, POLR1D, POLR3K, POLR2E, POLR2F, POLR2H, POLR2K, POLR2L, POLR3B, POLR3E, MAVS, RELA, POLR3D, ZBP1, POLR3GL, IKBKG, AIM2, POLR1C, IKBKE, IFNA1, IL1B, IL6, IL18, NFKB1, CCL5, CASP1, IL33 |
| D-Arginine and D-ornithine metabolism | SRC |
| D-Glutamine and D-glutamate metabolism | GLS2, GLS, GLUD1, GLUD2, DGLUCY |
| Dilated cardiomyopathy | CACNG3, CACNG2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, DAG1, DES, DMD, AGT, ADCY4, EMD, ITGA11, CACNG4, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, MYBPC3, MYH6, MYL2, MYL3, ATP2A1, ATP2A2, ATP2A3, PLN, PRKACB, PRKACG, CACNA2D3, CACNG8, CACNG7, CACNG6, RYR2, SGCA, SGCB, SGCD, SLC8A2, SLC8A1, SLC8A3, ACTC1, TGFB2, ACTG1, TNF, TPM2, TPM3, TPM4, TTN, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, ITGA10, ITGA8, CACNA2D2, CACNA2D4, ADCY1, ADCY2, ADCY3, GNAS, IGF1, ITGA6, ITGA4, ITGA5, ITGAV, ITGB1, LAMA2, MYH7, PRKACA, ACTB, TGFB1, TGFB3, TNF, TPM1, CACNA1S, CACNA2D1, ADCY1, ADCY3, LAMA2, PRKACA |
| DNA replication | RNASEH2A, FEN1, POLA2, RNASEH1, LIG1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, POLE3, POLA1, POLD1, POLD2, POLE, PRIM1, PRIM2, POLE4, POLD4, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, SSBP1, RNASEH2B, RAF1, BMI1, POLD3 |
| Dopaminergic synapse | AKT3, CREB3, GNB5, ADCY5, ATF2, ATF6B, CALML6, DDC, DRD1, DRD2, DRD3, DRD4, AKT2, LRTOMT, FOS, GNAI2, GNAI3, GNAL, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRIA1, GRIA2, GRIA3, GRIN2A, GRIN2B, ITPR1, ITPR2, ITPR3, KCNJ9, KIF5A, KIF5B, ARNTL, ARRB2, ATF4, CALY, GNG13, CALML5, PLCB2, PLCB3, GNG2, PPP1CB, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKCB, PRKCG, PPP2R2D, GNG12, MAPK11, MAPK9, MAPK10, MAPK13, GNB4, MAPK12, SCN1A, CREB3L2, SLC6A3, SLC18A2, TH, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PPP1R1B, CREB3L3, CALML4, GNG8, CREB5, COMT, CREB1, MAPK14, CREB3L4, AKT1, PLCB1, GNAI1, GNAO1, GNAS, GSK3A, GSK3B, KCNJ5, KCNJ6, KIF5C, MAOA, PPP1CC, PPP2CB, PRKACA, PRKCA, MAPK8, SLC18A1, CALM1, CLOCK, CREB1, CREB3L4, GSK3A, KCNJ5, KCNJ6, KIF5C, PPP1CC, PPP2R3C, PPP2CB, PRKACA, PRKCA, SLC18A1, CALM1 |
| Drug metabolism - cytochrome P450 | UGT2B11, UGT2A1, GSTO2, ADH1A, ADH1B, ADH4, ADH5, ADH6, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D7, CYP2D6, CYP2E1, CYP3A5, ALDH1A3, ALDH3B1, ALDH3B2, FMO1, FMO3, FMO4, HPGDS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, AOX1, MGST2, MGST3, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, GSTO1, LIPE, PIK3CA, PIK3CB, RAF1, CGA, LIPE, PIK3CA, PIK3CB, CGA, GSTM3 |
| Drug metabolism - other enzymes | NME6, CES1, UGT2B11, UGT2A1, GSTO2, UPP2, CYP2A6, CYP2E1, DPYD, DPYS, DUT, TYMP, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, GUSB, NME7, HPRT1, IMPDH1, IMPDH2, ITPA, MGST2, MGST3, MPO, NME1, NME2, NME3, NME4, RRM2B, CMPK1, UPB1, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UCKL1, UGT2A2, RRM1, RRM2, NME1-NME2, TK1, TK2, TPMT, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UCK2, UMPS, UPP1, UGT2A3, UCK1, CES2, GMPS, NAT1, GSTO1, CDA, PIK3CA, PIK3CB, RAF1, CGA, JUN, RAF1, SRC, GSTM3 |
| ECM-receptor interaction | LAMC3, CHAD, COL1A2, COL2A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COL9A2, COL9A3, COMP, COL6A6, FREM1, DAG1, ITGA11, SV2C, COL6A5, GP1BA, GP1BB, GP9, HMMR, HSPG2, TNC, FREM2, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, AGRN, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, GP6, RELN, SDC1, SDC4, TNN, SPP1, THBS1, THBS2, THBS3, THBS4, TNXB, VTN, FRAS1, ITGA10, ITGA8, CD36, CD47, SV2B, SV2A, COL1A1, FN1, ITGA6, ITGA4, ITGA5, ITGAV, ITGB1, LAMA2, VWF, CD44, LAMA2 |
| EGFR tyrosine kinase inhibitor resistance | AKT3, BCL2L11, EIF4E, EIF4EBP1, ERBB3, AKT2, FGF2, FOXO3, GAB1, SHC2, GRB2, HRAS, JAK1, JAK2, KRAS, SHC4, NF1, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, PRKCB, PRKCG, PDGFC, MAP2K1, MAP2K2, BCL2L1, RPS6, RPS6KB1, RPS6KB2, SHC1, SOS2, BRAF, TGFA, PDGFD, PIK3R3, EIF4E2, NRG2, EGF, EGFR, ERBB2, AKT1, FGFR3, FGFR2, MTOR, GAS6, GSK3B, HGF, NRG1, IGF1, IGF1R, IL6, IL6R, KDR, MET, PIK3CA, PIK3CB, PLCG1, PRKCA, AXL, MAPK1, MAPK3, BAD, PTEN, BAX, RAF1, BCL2, SOS1, SRC, STAT3, VEGFA, PIK3CB, PLCG1, PRKCA, TGFA |
| Endocrine and other factor-regulated calcium reabsorption | ADCY6, ADCY9, AP2M1, AP2S1, CLTA, CLTB, CLTC, AP2A1, AP2A2, AP2B1, DNM1, ESR1, DNM3, GNAQ, KLK1, KLK2, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2B1, ATP2B2, ATP2B3, PLCB2, PLCB3, PRKACB, PRKACG, PRKCB, PRKCG, PTH1R, BDKRB2, SLC8A2, SLC8A1, SLC8A3, CALB1, CLTCL1, RAB11A, KL, DNM2, ESR1, PLCB1, GNAS, PRKACA, PRKCA, VDR, ATP2B4, PRKACA, PRKCA |
| Endocrine resistance | AKT3, CDKN1A, CDKN1B, CDKN2C, CARM1, DLL3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CYP2D7, CYP2D6, JAG1, HBEGF, E2F2, E2F3, ADCY4, AKT2, ESR1, FOS, SHC2, DLL1, GPER1, GRB2, HRAS, JAG2, KRAS, SHC4, NOTCH1, NOTCH3, NOTCH4, PIK3CD, PIK3R1, PIK3R2, SHC3, PRKACB, PRKACG, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, PTK2, CCND1, RPS6KB1, RPS6KB2, MAPK12, BIK, SHC1, SOS2, BRAF, TP53, NCOA3, PIK3R3, ABCB11, NCOR1, CDKN2A, ADCY1, ADCY2, ADCY3, MAPK14, E2F1, EGFR, ERBB2, AKT1, ESR1, ESR2, MTOR, GNAS, IGF1, IGF1R, JUN, MDM2, MMP2, MMP9, PIK3CA, PIK3CB, MED1, PRKACA, MAPK1, MAPK3, MAPK8, BAD, BAX, RAF1, RB1, BCL2, SOS1, SP1, SRC, TP53, ADCY1, ADCY3, PIK3CB, MED1, PRKACA |
| Endocytosis | PDCD6IP, RNF103-CHMP3, ARPC5, ARPC4, ARPC3, ARPC1B, RNF41, STAM2, ARPC1A, ARFGEF2, ARFGEF1, STAMBP, RAB35, RAB31, WWP1, SNF8, VPS26B, VPS45, ACAP3, ARAP2, ARAP1, AGAP2, AGAP1, AGAP3, AP2M1, AP2S1, AGAP4, AGAP11, CLTA, CLTB, CLTC, CHMP4B, GRK7, VPS37A, WIPF2, GRK2, GRK3, AP2A1, DAB2, AP2A2, AP2B1, DNM1, EPS15, FGFR4, RAB11FIP2, EPN2, SPART, WASHC4, NEDD4L, PSD3, PIP5K1C, FOLR1, FOLR3, ACAP2, PSD4, CBLC, WASHC2C, SNX32, CHMP2B, DNM3, RAB11FIP5, ARFGAP3, CYTH4, SNX5, CHMP2A, AMPH, BIN1, GRK4, GRK5, GRK6, GIT1, CHMP4A, EPN1, SNX12, SH3KBP1, EHD4, EHD3, EHD2, HLA-F, HRAS, HSPA1A, HSPA6, HSPA8, IL2RB, IL2RG, CXCR1, CXCR2, ARF1, ARF3, ARF4, KIF5A, KIF5B, ARF5, ARF6, WASHC2A, LDLR, SMAD2, SMAD3, ARRB2, RAB8A, IQSEC3, NEDD4, ASAP1, PARD6A, WASHC3, VPS36, SH3GLB1, VPS28, CHMP1A, SPG21, CHMP5, VTA1, PDGFRA, CHMP3, VPS29, PLD1, PLD2, PML, EPN3, VPS37C, ASAP3, VPS35, ARFGAP1, PRKCZ, PARD3, PSD, SH3GLB2, CHMP1B, RAB22A, EPS15L1, SNX6, RAB4A, RAB5A, RAB5B, RAB5C, GRK1, SMAP1, ARAP3, SH3GL1, SH3GL2, SH3GL3, SMURF2, SNX2, TFR |
| Endometrial cancer | AKT3, CDKN1A, APC2, CTNNA1, CTNNA2, DDB2, GADD45A, ELK1, AKT2, FOXO3, GRB2, CTNNA3, APC, HRAS, ILK, KRAS, GADD45B, LEF1, POLK, PDPK1, PIK3CD, PIK3R1, PIK3R2, MAP2K1, MAP2K2, CCND1, SOS2, BRAF, TCF7, TP53, AXIN1, AXIN2, TCF7L1, PIK3R3, GADD45G, CTNNB1, EGF, EGFR, ERBB2, AKT1, GSK3B, MLH1, MYC, PIK3CA, PIK3CB, MAPK1, MAPK3, BAD, PTEN, BAK1, BAX, RAF1, SOS1, TCF7L2, TP53, CASP9, CDH1, GADD45G, PIK3CB |
| Epithelial cell signaling in Helicobacter pylori infection | TCIRG1, NOD1, ATP6V1G3, CSK, ATP6V0E2, HBEGF, ATP6V1C2, GIT1, CXCL1, CXCL2, CXCL3, IKBKB, CXCR1, CXCR2, LYN, NFKBIA, ATP6V0A4, F11R, ATP6V1D, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V0B, PLCG2, ATP6V1G2, ATP6V0A1, ATP6AP1, MAPK11, MAPK9, MAPK10, MAPK13, PTPRZ1, JAM2, RAC1, RELA, MAPK12, MAP2K4, TJP1, JAM3, IKBKG, ATP6V0E1, MAP3K14, ATP6V1E2, ATP6V0D1, ATP6V1F, ATP6V1G1, ADAM10, MAPK14, EGFR, ATP6V0A2, CXCL8, JUN, MET, NFKB1, PAK1, PLCG1, MAPK8, PTPN11, CCL5, SRC, ADAM17, CASP3, CDC42, ADAM10, PLCG1 |
| Epstein-Barr virus infection | AKT3, BCL2L11, CDK6, PSMD14, CDKN1A, CDKN1B, IRF9, TAB1, ADRM1, CR2, DDB2, GADD45A, E2F2, E2F3, AKT2, FCER2, SNW1, TAB2, TBK1, HDAC2, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, HES1, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, RBPJ, IKBKB, CXCL10, IRAK1, IRF3, IRF7, ITGAL, JAK1, JAK3, ENTPD8, LYN, MYD88, GADD45B, NEDD4, NFKB2, NFKBIA, NFKBIB, NFKBIE, OAS1, OAS2, IRAK4, POLK, PIK3CD, PIK3R1, PIK3R2, PLCG2, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K3, MAP2K6, MAP2K7, EIF2AK2, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD7, PSMD8, PSMD12, PSMD13, MAVS, RAC1, CCND1, RELA, RELB, MAPK12, BID, MAP2K4, SKP2, STAT2, SYK, MAP3K7, TAP1, TAP2, TAPBP, BTK, TNF, TP53, TRAF2, TRAF3, TRAF5, TRAF6, USP7, SEM1, CALR, PIK3R3, IKBKG, TRADD, FADD, SAP30, CCND3, CCNE1, MAP3K14, CCNE2, CD3E, CD3G, CD247, CD19, CIR1, ENTPD3, CD40, NCOR2, ISG15, IKBKE, CD58, PSMD6, CDK2, GADD45G, MAPK14, E2F1, AKT1, SIN3A, PDIA3, HDAC1, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, AP |
| ErbB signaling pathway | AKT3, CDKN1A, CDKN1B, PAK4, NRG3, CRK, CRKL, NRG4, HBEGF, EIF4EBP1, ELK1, ERBB3, EREG, AKT2, ABL1, GAB1, SHC2, ABL2, GRB2, HRAS, AREG, KRAS, SHC4, NCK1, PAK3, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, PRKCB, PRKCG, MAPK9, MAPK10, MAP2K1, MAP2K2, MAP2K7, PAK6, PAK5, PTK2, RPS6KB1, RPS6KB2, MAP2K4, SHC1, SOS2, BRAF, STAT5A, STAT5B, BTC, TGFA, CAMK2A, CAMK2B, CAMK2D, CAMK2G, NCK2, PIK3R3, CBL, CBLB, NRG2, BAX, PIK3CA, PIK3CB, F3, JUN, PIK3CA, PIK3CB, BAX, HSD3B1, HSD3B2, RAP1A, JUN, MET, SRC, FYN, JUN, CYCS, BAX, JUN, SRC, JUN, MEFV, PIK3CB, PLCG1, PRKCA, TGFA |
| Estrogen signaling pathway | AKT3, CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, CALML6, HBEGF, KRT24, ADCY4, AKT2, ESR1, FKBP5, FOS, GABBR1, SHC2, KRT23, GNAI2, GNAI3, GNAQ, GPER1, GRB2, GRM1, HRAS, HSPA1A, HSPA6, HSPA8, ITPR1, ITPR2, ITPR3, KCNJ9, KRAS, KRT9, KRT13, KRT14, KRT15, KRT17, KRT18, KRT19, KRT32, SHC4, ATF4, CALML5, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, SHC3, POMC, KRT20, PRKACB, PRKACG, PRKCD, MAP2K1, MAP2K2, RARA, SHC1, CREB3L2, SOS2, TFF1, TGFA, HSP90B1, CALM2, CALM3, CALML3, NCOA3, CREB3L3, PIK3R3, NCOA1, KRT38, EBAG9, CALML4, CREB5, NCOA2, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CTSD, EGFR, AKT1, ESR1, ESR2, FKBP4, PLCB1, GNAI1, GNAO1, GNAS, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSP90AA1, HSP90AB1, JUN, KCNJ5, KCNJ6, KRT10, MMP2, MMP9, NOS3, PGR, PIK3CA, PIK3CB, PRKACA, MAPK1, MAPK3, RAF1, RARA, BCL2, SOS1, SP1, SRC, CALM1, GABBR2, ADCY1, ADCY3, CREB1, CREB3L4, HSP90AB1, KCNJ5, KCNJ6, PIK3CB, PRKACA, RARA, TGFA, CALM1, GABBR2 |
| Ether lipid metabolism | CEPT1, PLAAT3, PLD4, ENPP6, PLB1, PLD3, LPCAT4, TMEM86B, PLA2G2D, GDPD1, PLA2G3, PAFAH1B3, PAFAH2, ENPP2, PLA2G1B, PLA2G4A, PLA2G5, PLD1, PLD2, LPCAT2, CHPT1, UGT8, GDPD3, PLA2G7, LPCAT1, PLA2G12A, PLA2G10, PLA2G12B, AGPS, SELENOI, PLA2G4C, PLPP1, PLPP2, PLPP3, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, PAFAH1B1 |
| Fanconi anemia pathway | CENPS-CORT, POLI, EME2, CENPX, ERCC4, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FAN1, UBE2T, HES1, POLN, CENPS, POLK, REV1, POLH, FANCL, WDR48, RAD51C, REV3L, RPA1, RPA2, RPA3, BLM, SLX1B, PALB2, RMI1, MUS81, FAAP100, BRIP1, ATRIP, SLX4, TOP3B, FAAP24, JUN, MYC, PIK3CA, PIK3CB, CYCS, BAX, RAF1, PIK3CA, PIK3CB, BAX, EME1, FANCM, RAD51 |
| Fat digestion and absorption | AGPAT1, AGPAT2, SLC27A4, CLPS, PLA2G2D, GOT2, NPC1L1, APOA1, APOA4, MOGAT3, SLC27A1, MTTP, PLA2G3, PLA2G1B, PLA2G5, PNLIP, PNLIPRP1, PNLIPRP2, MOGAT2, PLA2G12A, PLA2G10, PLA2G12B, DGAT2, LIPF, PLPP1, PLPP2, PLPP3, DGAT1, CD36, SCARB1, ABCA1, APOB, PLA2G2A |
| Fatty acid biosynthesis | ACSF3, ACSL1, ACSL3, ACSL4, FASN, ACSBG1, ACSL6, MCAT, ACACA, ACACB, ACSL5, OXSM, OLAH, HSD17B8, ACSBG2, CBR4 |
| Fatty acid degradation | ACAA2, ECI2, ADH1A, ADH1B, CPT1C, ADH4, ADH5, ADH6, CPT1A, CPT1B, CPT2, CYP4A11, ECI1, ECHS1, ALDH2, ACSL1, ACSL3, ACSL4, ALDH9A1, ALDH3A2, ACSBG1, ACSL6, GCDH, ACAA1, HADHA, HADHB, HADH, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACOX1, ACSL5, ACSBG2, ACOX3, RAF1 |
| Fatty acid elongation | ACAA2, ACOT2, ACOT7, THEM4, ACOT4, ECHS1, HACD2, THEM5, HADHA, HADHB, HADH, HSD17B12, HACD3, ELOVL2, PPT1, ELOVL5, ELOVL1, ELOVL4, ELOVL6, ELOVL3, HACD1, TECR |
| Fatty acid metabolism | ACAA2, CPT1C, CPT1A, CPT1B, CPT2, ECHS1, ACSF3, HACD2, ACSL1, ACSL3, ACSL4, FASN, ACSBG1, ACSL6, MCAT, ACAA1, HADHA, HADHB, HADH, ACACA, ACADL, ACADM, ACADS, ACADSB, ACADVL, FADS1, ACOX1, HSD17B12, HACD3, ACSL5, ELOVL2, OXSM, PPT1, ELOVL5, SCD, SCP2, ELOVL1, ELOVL4, ELOVL6, HSD17B8, SCD5, ACSBG2, ACOX3, ELOVL3, CBR4, HACD1, FADS2, TECR, HSD17B4, ACAT1 |
| Fc epsilon RI signaling pathway | AKT3, VAV3, AKT2, FCER1A, MS4A2, FCER1G, ALOX5, ALOX5AP, LAT, GRB2, HRAS, IL3, IL13, INPP5D, KRAS, LCP2, LYN, PDPK1, PIK3CD, PIK3R1, PIK3R2, PLA2G4A, PLCG2, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, RAC1, RAC2, RAC3, MAPK12, MAP2K4, SOS2, SYK, BTK, TNF, VAV1, VAV2, PIK3R3, PLA2G4C, GAB2, MAPK14, AKT1, FYN, IL4, IL5, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, MAPK8, RAF1, SOS1, TNF, PIK3CB, PLCG1, PRKCA |
| Fc gamma R-mediated phagocytosis | AKT3, ARPC5, ARPC4, ARPC3, ARPC1B, WASF2, VAV3, ARPC1A, CFL2, WASF3, CRK, CRKL, DOCK2, AKT2, FCGR2A, FCGR2B, FCGR3B, PIP5K1C, LAT, AMPH, BIN1, HCK, INPP5D, ARF6, LIMK1, LYN, MARCKS, MYO10, ASAP1, PIK3CD, PIK3R1, PIK3R2, PLA2G4A, PLCG2, PLD1, PLD2, ASAP3, PRKCB, PRKCD, PRKCE, PRKCG, MAP2K1, SPHK2, PTPRC, RAC1, RAC2, RPS6KB1, RPS6KB2, MARCKSL1, NCF1, SYK, VASP, VAV1, VAV2, WAS, ARPC5L, PIP5K1A, PIP5K1B, PIK3R3, SCIN, PLA2G4C, PLPP1, PLPP2, PLPP3, ASAP2, WASF1, GAB2, ARPC2, CFL1, DNM2, AKT1, FCGR3A, GSN, LIMK2, PAK1, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, RAF1, PLA2G6, CDC42, ARPC2, GSN, ASAP1, PIK3CB, PLCG1, PRKCA |
| Ferroptosis | LPCAT3, SAT2, CYBB, ACSL1, ACSL3, ACSL4, ACSL6, SLC39A14, FTH1, FTL, GCLC, SLC40A1, MAP1LC3C, PCBP1, PCBP2, ACSL5, STEAP3, PRNP, SAT1, SLC39A8, SLC3A2, TFRC, TP53, VDAC2, NCOA4, MAP1LC3B, MAP1LC3A, FTMT, ATG5, ATG7, ALOX15, GPX4, HMOX1, SLC11A2, TF, TP53, VDAC2, VDAC3, ATG7, SLC11A2, VDAC3 |
| Fluid shear stress and atherosclerosis | AKT3, CDH5, KLF2, GSTO2, CTSL, CYBA, CALML6, NQO1, DUSP1, EDN1, AKT2, FOS, TXN2, NOX1, GPC1, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, IKBKB, IL1R1, ITGA2B, ITGB3, MIR10A, MEF2C, MAP3K5, MGST2, MGST3, ASS1, NPPC, PDGFA, PDGFB, PIAS4, PECAM1, CALML5, PIK3CD, PIK3R1, PIK3R2, PRKAA2, PRKCZ, MAPK7, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K5, MAP2K6, MAP2K7, PTK2, RAC1, RAC2, RAC3, RELA, MAPK12, CCL2, SDC1, SDC2, SDC4, MAP2K4, NCF1, BMPR1A, SUMO3, SUMO2, MAP3K7, THBD, ACTG1, TNF, TP53, HSP90B1, VCAM1, CALM2, CALM3, CALML3, PIK3R3, IKBKG, CAV1, CAV2, CAV3, SQSTM1, ACVR1, ARHGEF2, CALML4, ACVR2A, ACVR2B, GSTO1, KEAP1, MAPK14, CTNNB1, AKT1, GSTM1, GSTM3, GSTP1, GSTT1, HMOX1, HSP90AA1, HSP90AB1, ICAM1, IFNG, IL1A, IL1B, ITGAV, JUN, KDR, RHOA, MEF2A, MGST1, MMP2, MMP9, NFE2L2, NFKB1, NOS3, PIK3CA, PIK3CB, PLAT, PRKAA1, MAPK8, TRPV4, BCL2, ACTB, BMP4, BMPR1B, BMPR2, SRC, TNF, TNFRSF1A, TP53, TXN, SUMO1, VEGFA, IL1R2, CALM1, CAV1, GSTM3, HSP90AB1, RHOA, PIK3CB, PRKAA1, TRPV4, CALM1 |
| Focal adhesion | AKT3, PAK4, LAMC3, MYL12B, VAV3, MYL12A, CHAD, COL1A2, COL2A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COL9A2, COL9A3, COMP, COL6A6, CRK, CRKL, DIAPH1, DOCK1, ELK1, AKT2, ITGA11, FLNB, FLNC, FLT4, PIP5K1C, COL6A5, SHC2, GRB2, RAPGEF1, ARHGAP35, PARVB, HRAS, BIRC2, XIAP, TNC, MYLK4, ILK, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, ARHGAP5, SHC4, MYL2, MYL5, MYLK, PPP1R12A, PPP1R12B, PAK3, PDGFA, PDGFB, PDGFRA, PDGFRB, PDPK1, PIK3CD, PIK3R1, PIK3R2, SHC3, PPP1R12C, PPP1CB, PARVA, PRKCB, PRKCG, MAPK9, MAPK10, PDGFC, MAP2K1, RELN, PAK6, PAK5, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RASGRF1, CCND1, ROCK1, TNN, PARVG, SHC1, SOS2, SPP1, BRAF, THBS1, THBS2, THBS3, THBS4, TLN1, ACTG1, TNXB, VASP, VAV1, VAV2, VCL, VEGFB, VEGFC, VTN, ZYX, PDGFD, ACTN4, CAPN2, TLN2, PIP5K1A, PIP5K1B, PIK3R3, ITGA10, ITGA8, MYLK2, CAV1, CAV2, CAV3, ACTN1, CCND3, MYLK3, MYL10, ROCK2, BCAR1, COL1A1, CTNNB1, EGF, EGFR, ERBB2, AKT1, |
| Folate biosynthesis | GPHN, TPH2, DHFR, DHFR2, AKR1B1, FPGS, ALPI, ALPL, ALPP, GCH1, MOCS2, PAH, PCBD1, MOCOS, AKR1B10, PTS, QDPR, SPR, TH, TPH1, CBR1, GGH, HLA-DRA |
| FoxO signaling pathway | AKT3, BCL2L11, C8orf44-SGK3, SGK2, CDKN1A, CDKN1B, CDKN2B, CDKN2D, KLF2, PLK2, GABARAP, GABARAPL2, FBXO32, AGAP2, PLK3, CREBBP, CSNK1E, GADD45A, S1PR1, EP300, AKT2, FOXG1, FOXO3, SGK3, GABARAPL1, FBXO25, GRB2, GRM1, HRAS, PRMT1, IKBKB, IL7R, INS, IRS1, KRAS, SMAD3, SMAD4, FOXO4, GADD45B, PCK2, PRKAG2, PDPK1, NLK, PIK3CD, PIK3R1, PIK3R2, PLK1, PRKAA2, PRKAB1, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, G6PC2, RAG2, RBL2, CCND1, BCL6, MAPK12, SGK1, SKP2, SLC2A4, BNIP3, SOS2, BRAF, STK4, TGFB2, TGFBR1, TGFBR2, USP7, SETD7, IRS4, PIK3R3, CCNB3, IRS2, S1PR4, CCNG2, ATG12, HOMER3, HOMER2, HOMER1, CDK2, PLK4, GADD45G, MAPK14, EGF, EGFR, AKT1, FOXO1, SIRT1, IGF1, IGF1R, FASLG, IL6, IL10, INSR, MDM2, ATM, PIK3CA, PIK3CB, PRKAA1, MAPK1, MAPK3, MAPK8, PTEN, RAF1, RAG1, SOD2, SOS1, STAT3, STK11, TGFB1, TGFB3, CAT, TNFSF10, CCNB1, CCND2, CCNB2, G6PC3, PLK4, GADD45G, PIK3CB, PRKAA1, STK11, CCND2 |
| Fructose and mannose metabolism | FCSK, FBP1, ALDOA, ALDOB, ALDOC, AKR1B1, TKFC, GMDS, GMPPB, GMPPA, HK2, HK3, KHK, MPI, PFKFB2, PFKFB4, PFKL, PFKM, PFKP, PMM1, ENOSF1, AKR1B10, TIGAR, SORD, TPI1, GFUS, HKDC1, FBP2, MET, PIK3CA, HK1, PFKFB3 |
| GABAergic synapse | GPHN, GNB5, SLC38A3, ADCY5, ADCY6, ADCY7, GABARAP, GABARAPL2, ADCY8, ADCY9, SLC32A1, ABAT, ADCY4, GABRR3, GABARAPL1, GABBR1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GABRG1, GABRG2, GABRG3, GABRP, GABRR2, GAD1, GAD2, GLS2, GLS, GLUL, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, NSF, GNG13, PLCL1, GNG2, SLC38A2, PRKACB, PRKACG, PRKCB, PRKCG, GABRQ, GNG12, SLC12A5, GNB4, SLC6A11, SLC6A12, SLC6A13, TRAK2, CACNA1A, CACNA1B, CACNA1C, CACNA1D, SLC38A1, HAP1, SLC38A5, GNG8, ADCY1, ADCY2, ADCY3, GNAI1, GNAO1, KCNJ6, PRKACA, PRKCA, SLC6A1, SRC, CACNA1S, GABBR2, ADCY1, ADCY3, KCNJ6, PRKACA, PRKCA, SLC6A1, GABBR2 |
| Galactose metabolism | GALM, AKR1B1, GALE, GALK1, GALT, GANC, GCK, B4GALT1, GLA, HK2, HK3, LALBA, LCT, PFKL, PFKM, PFKP, PGM1, PGM2, AKR1B10, G6PC2, SI, UGP2, HKDC1, B4GALT2, MGAM, MGAM2, PIK3CB, RAF1, RAP1A, SRC, HK1 |
| Gap junction | TUBB4A, TUBB4B, MAP3K2, ADCY5, ADCY6, TUBA3E, ADCY7, TUBA3D, ADCY8, ADCY9, CSNK1D, ADRB1, DRD1, DRD2, LPAR1, ADCY4, TUBB, GNA11, GNAI2, GNAI3, GNAQ, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A1, GUCY1B1, HRAS, HTR2B, HTR2C, TUBB8, ITPR1, ITPR2, ITPR3, KRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PLCB2, PLCB3, PRKACB, PRKACG, PRKCB, PRKCG, PRKG1, MAPK7, PDGFC, MAP2K1, MAP2K2, MAP2K5, GJD2, SOS2, TJP1, TUBB2A, TUBAL3, PDGFD, TUBB6, TUBA1C, TUBB3, ADCY1, ADCY2, ADCY3, EGF, EGFR, PLCB1, GJA1, GNAI1, GNAS, HTR2A, TUBB2B, TUBA8, PRKACA, PRKCA, MAPK1, MAPK3, RAF1, SOS1, SRC, TUBA4A, TUBA3C, CDK1, ADCY1, ADCY3, HTR2A, PRKACA, PRKCA |
| Gastric acid secretion | ADCY5, ADCY6, ADCY7, CHRM3, ADCY8, ADCY9, SLC26A7, CALML6, ADCY4, GNAI2, GNAI3, GNAQ, HRH2, MYLK4, ITPR1, ITPR2, ITPR3, KCNJ1, KCNJ2, KCNJ10, KCNJ15, KCNJ16, KCNK2, MYLK, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP4A, ATP4B, CALML5, PLCB2, PLCB3, KCNK10, PRKACB, PRKACG, PRKCB, PRKCG, SLC4A2, SLC9A1, SST, ACTG1, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, MYLK2, MYLK3, CALML4, ADCY1, ADCY2, CFTR, ADCY3, PLCB1, GNAI1, GNAS, KCNQ1, PRKACA, PRKCA, ACTB, EZR, CA2, CALM1, ADCY1, ADCY3, KCNQ1, PRKACA, PRKCA, CALM1 |
| Gastric cancer | AKT3, CDH17, CDKN1A, CDKN1B, APC2, CDKN2B, CDX2, CSNK1A1L, CSNK1A1, CTNNA1, CTNNA2, DDB2, GADD45A, DVL1, DVL2, DVL3, E2F2, E2F3, AKT2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FRAT2, FZD2, GAB1, SHC2, FGF20, FGF21, FGF22, GRB2, CTNNA3, APC, HRAS, JUP, KRAS, SHC4, LRP6, LRP5, SMAD2, SMAD3, SMAD4, MUC2, GADD45B, LEF1, WNT16, POLK, PIK3CD, PIK3R1, PIK3R2, SHC3, WNT4, MAP2K1, MAP2K2, RARB, CCND1, RPS6KB1, RPS6KB2, RXRG, SHC1, SOS2, BRAF, TCF7, TERC, TGFB2, TGFBR1, TGFBR2, TP53, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, FGF23, WNT5B, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, PIK3R3, FGF18, WNT3A, CCNE1, CCNE2, FGF19, CDK2, GADD45G, CTNNB1, E2F1, EGF, EGFR, ERBB2, AKT1, FGF3, FGF4, FGF8, FGF9, FGFR2, MTOR, GSK3B, HGF, MET, MLH1, MYC, ABCB1, PIK3CA, PIK3CB, MAPK1, MAPK3, BAK1, BAX, RAF1, RB1, BCL2, RXRA, RXRB, SHH, SOS1, TCF7L2, TERT, TGFB1, TGFB3, TP53, WNT5A, FGF17, CDH1, GADD45G, FGF4, PIK3CB, RXRA, RXRB |
| Glioma | AKT3, CDK6, CDKN1A, CALML6, DDB2, GADD45A, E2F2, E2F3, AKT2, SHC2, GRB2, HRAS, KRAS, SHC4, GADD45B, POLK, PDGFA, PDGFB, PDGFRA, PDGFRB, CALML5, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, PRKCB, PRKCG, MAP2K1, MAP2K2, CAMK1D, CCND1, SHC1, SOS2, BRAF, TGFA, TP53, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PIK3R3, CAMK1, CALML4, CDKN2A, GADD45G, E2F1, EGF, EGFR, AKT1, MTOR, IGF1, IGF1R, MDM2, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, PTEN, BAK1, BAX, RAF1, RB1, SOS1, TP53, CALM1, CAMK4, GADD45G, PIK3CB, PLCG1, PRKCA, TGFA, CALM1 |
| Glucagon signaling pathway | AKT3, CREB3, PPARGC1A, CPT1C, CPT1A, CPT1B, ATF2, CREBBP, SIK1, CALML6, EP300, AKT2, FBP1, SIK2, GCGR, GCK, GNAQ, GYS1, GYS2, ACACA, ACACB, PRMT1, ITPR1, ITPR2, ITPR3, LDHB, ATF4, PCK2, PDE3B, PRKAG2, PDHA1, PDHB, CALML5, PFKL, PFKM, PFKP, PGAM2, PHKA2, PHKB, PHKG1, PHKG2, PKM, PLCB2, PLCB3, PPARA, PPP3CA, PPP4C, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKAA2, PRKAB1, PRKACB, PPP4R3A, PRKACG, PPP4R3B, G6PC2, PYGB, PYGL, PYGM, CREB3L2, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB3L3, FBP2, CALML4, LDHAL6B, CREB5, ADCY2, CREB1, CREB3L4, AKT1, FOXO1, PLCB1, SIRT1, GNAS, LDHA, LDHC, PGAM4, PDHA2, PGAM1, PRKAA1, PRKACA, SLC2A1, CALM1, G6PC3, CREB1, CREB3L4, PDHA2, PRKAA1, PRKACA, SLC2A1, CALM1 |
| Glutamatergic synapse | GNB5, SLC38A3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, GRIN3A, GRIN3B, GRK2, GRK3, DLG4, ADCY4, SHANK2, GLS2, GLS, GLUL, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRIA1, GRIA2, GRIA3, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, ITPR1, ITPR2, ITPR3, SHANK1, GNG13, PLA2G4A, PLCB2, PLCB3, PLD1, PLD2, GNG2, SLC38A2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PRKCB, PRKCG, GNG12, SLC17A7, SLC17A6, GNB4, SLC1A2, SLC1A3, SLC1A6, SLC1A7, TRPC1, CACNA1A, CACNA1C, CACNA1D, SLC38A1, SHANK3, PLA2G4C, DLGAP1, GNG8, HOMER3, HOMER2, HOMER1, ADCY1, ADCY2, ADCY3, PLCB1, GNAI1, GNAO1, GNAS, PRKACA, PRKCA, MAPK1, MAPK3, SLC1A1, ADCY1, ADCY3, PRKACA, PRKCA, SLC1A1 |
| Glutathione metabolism | GSTO2, GGT1, GGT7, OPLAH, GCLC, HPGDS, GPX2, GPX3, GPX7, ANPEP, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, IDH2, MGST2, MGST3, ODC1, RRM2B, LAP3, TXNDC12, PGD, RRM1, RRM2, SMS, SRM, GGCT, CHAC1, NAT8, GSTO1, PRDX6, JUN, PIK3CA, PIK3CB, JUN, MEFV, JUN, PIK3CA, PIK3CB, RAF1, SRC, KIR2DS2, FYN, GPX5, GSTM3 |
| Glycerolipid metabolism | AKR1A1, AGPAT1, AGPAT2, MGLL, MOGAT1, MBOAT2, GLYCTK, DGKK, DGKA, DGKB, DGKG, DGKH, DGKQ, PLPP4, ALDH2, ALDH9A1, ALDH3A2, AKR1B1, LPIN1, LCLAT1, TKFC, GK, GK2, GLA, MOGAT3, LIPC, LPL, PNLIP, PNLIPRP1, PNLIPRP2, AGK, AGPAT3, AGPAT4, AKR1B10, GPAM, LPIN3, MOGAT2, PNPLA3, PLPP5, DGAT2, GPAT3, LIPF, DGKZ, DGKE, DGKD, PLPP1, PLPP2, PLPP3, DGAT1, DGKI, LIPG, LPIN2, LIPE, PFKFB3, GPAT4, GPAT2 |
| Glycerophospholipid metabolism | LPCAT3, CEPT1, CDS1, PEMT, CDIPT, LYPLA1, AGPAT1, AGPAT2, PNPLA6, CHAT, PLAAT3, PLD4, MBOAT2, DGKK, PLB1, DGKA, DGKB, DGKG, DGKH, DGKQ, PHOSPHO1, PLPP4, GPD1L, LPIN1, PLD3, PLA2G15, PISD, LCLAT1, LPCAT4, PLA2G2D, GPD2, PNPLA7, LCAT, PLA2G3, PCYT1A, PLA1A, PLA2G1B, PLA2G4A, PLA2G5, PLD1, PLD2, CRLS1, LPCAT2, ETNK2, ETNK1, GPCPD1, AGPAT3, AGPAT4, ADPRM, CHPT1, GPAM, PCYT2, LPIN3, MBOAT7, LPCAT1, PTDSS2, PLA2G12A, PLA2G10, GNPAT, PLPP5, PLA2G12B, GPAT3, DGKZ, DGKE, DGKD, SELENOI, PLA2G4C, PLPP1, PLPP2, PLPP3, DGKI, PCYT1B, PGS1, LPIN2, PTDSS1, PIK3CA, PIK3CB, PIK3CA, PIK3CB, RAF1, CGA, MAS1, HLA-A, GPAT4, GPAT2, GPD2, ACHE, TAZ |
| Glycine, serine and threonine metabolism | SDS, SDSL, GLYCTK, CTH, SARDH, AGXT, ALAS1, GCAT, PHGDH, GATM, GCSH, GNMT, GLDC, AMT, DMGDH, AOC2, PIPOX, PGAM2, PSPH, SRR, SHMT1, SHMT2, BPGM, AOC3, GRHPR, RAF1, CYCS, BAX, BAX, CYCS, BAX, PPM1D, HLA-A, HLA-B, DLD, CHDH |
| Glycolysis / Gluconeogenesis | AKR1A1, ADH1A, ADH1B, ADH4, ADH5, ADH6, GALM, DLAT, ENO2, ENO3, ALDH2, ALDH1A3, FBP1, ALDH3B1, ALDH3B2, ALDH9A1, ALDH3A2, ALDOA, ALDOB, ALDOC, GCK, GPI, HK2, HK3, LDHB, PCK2, PDHA1, PDHB, PFKL, PFKM, PFKP, PGAM2, PGM1, PKLR, PKM, PGM2, ACSS2, G6PC2, BPGM, TPI1, HKDC1, ADPGK, ACSS1, FBP2, LDHAL6B, MINPP1, DLD, ENO1, GAPDH, GAPDHS, PFKFB3, GAA, GAA, PIK3CA, PIK3CB, ND4, SETD2, PLOD1, CKM, MGAT1, DLD, HK1, ENO4, PDHA2 |
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | UST, CHST14, B3GALT6, CHST13, CHSY1, B3GAT3, DSE, CHSY3, CHST11, CHST15, CSGALNACT2, CHST12, CSGALNACT1, CHST7, XYLT1, XYLT2, CHPF, CHST3 |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | B3GALT6, EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, B3GAT3, HS6ST3, NDST1, XYLT1, XYLT2, NDST4, NDST2, HS6ST2, NDST3, HS6ST1, HS2ST1, HS3ST3B1, HS3ST3A1, HS3ST2, HS3ST1 |
| Glycosaminoglycan biosynthesis - keratan sulfate | CHST4, FUT8, B4GALT1, CHST6, ST3GAL1, ST3GAL2, B4GALT4, B4GALT3, B4GALT2, B3GNT7, CHST2 |
| Glycosaminoglycan degradation | HPSE, HGSNAT, GALNS, GNS, GUSB, IDS, IDUA, ARSB, NAGLU, HPSE2, SGSH, HYAL3, HYAL2, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1 |
| Glycosphingolipid biosynthesis - ganglio series | ST6GALNAC3, B4GALNT1, ST6GALNAC4, ST8SIA5, ST3GAL1, ST3GAL2, ST8SIA1, ST6GALNAC5, SLC33A1, HLA-E, HLA-G, KIR2DL2, FYN |
| Glycosphingolipid biosynthesis - globo and isoglobo series | B3GALT5, FUT9, A3GALT2, FUT2, GLA, NAGA, A4GALT, ST3GAL1, ST3GAL2, ST8SIA1, B3GALNT1, HLA-DRA, HLA-DRB1 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | B3GALT5, B3GNT3, ST3GAL6, FUT9, FUT2, FUT3, FUT5, FUT6, FUT7, GCNT2, B4GALT1, ABO, A4GALT, ST3GAL4, ST8SIA1, B3GNT4, B3GNT5, B4GALT4, B4GALT3, B4GALT2, B3GALNT1, B3GALT2, B3GALT1, HLA-DQB1 |
| Glycosylphosphatidylinositol | PIGK, PIGU, PIGN, GPLD1, PIGW, PIGP, PIGT, PIGA, PIGF, PIGH, PIGG, PIGX, PIGV, PGAP1, PIGO, PIGY, GPAA1, DPM2, PIGQ, PIGM, PIGS, PIGL, PIGB |
| Glyoxylate and dicarboxylate metabolism | HOGA1, AFMID, GLYCTK, CS, AGXT, GCSH, GLDC, AMT, GLUL, PGP, MDH1, MDH2, ACO1, ACO2, PCCA, PCCB, HAO2, HAO1, ACSS2, SHMT1, SHMT2, HYI, ACSS1, MCEE, GRHPR, MYC, PIK3CA, PIK3CB, DLD |
| GnRH secretion | AKT3, AKT2, GABBR1, GNA11, GNAQ, GPER1, HRAS, HCN1, ITPR1, ITPR2, ITPR3, KCNJ9, KCNN1, KCNN2, KCNN3, KCNN4, KRAS, ARRB2, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PRKCB, PRKCG, MAP2K1, MAP2K2, HCN2, SPP1, TRPC1, TRPC4, TRPC5, CACNA1C, CACNA1D, PIK3R3, CACNA1I, CACNA1H, CACNA1G, CGA, AKT1, ESR2, PLCB1, GNRH1, GNRH2, KCNJ5, KCNJ6, KISS1, LHB, PIK3CA, PIK3CB, PRKCA, MAPK1, MAPK3, RAF1, CACNA1S, KISS1R, GABBR2, KCNJ5, KCNJ6, PIK3CB, PRKCA, GABBR2 |
| GnRH signaling pathway | MAP3K2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CALML6, HBEGF, EGR1, ADCY4, ELK1, PTK2B, GNA11, GNAQ, GNRHR, GRB2, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP3K1, MAP3K3, MAP3K4, MMP14, ATF4, CALML5, PLA2G4A, PLCB2, PLCB3, PLD1, PLD2, PRKACB, PRKACG, PRKCB, PRKCD, MAPK7, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, MAPK12, MAP2K4, SOS2, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PLA2G4C, CALML4, ADCY1, ADCY2, CGA, ADCY3, MAPK14, EGFR, PLCB1, FSHB, GNAS, GNRH1, GNRH2, GNRHR, JUN, LHB, MMP2, PRKACA, PRKCA, MAPK1, MAPK3, MAPK8, RAF1, SOS1, SRC, CACNA1S, CALM1, CDC42, ADCY1, ADCY3, PRKACA, PRKCA, CALM1 |
| Graft-versus-host disease | GZMB, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, KIR2DL1, KIR3DL2, KLRC1, TNF, CD28, CD80, CD86, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, IFNG, FAS, IL1A, IL1B, IL2, FASLG, IL6, KIR2DL2, PRF1, TNF |
| Growth hormone synthesis, secretion and action | AKT3, CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, CREBBP, ATF6B, CRK, CRKL, CSH1, CSH2, ADCY4, EP300, AKT2, FOS, SHC2, GH2, GHR, GHRHR, GHSR, GNA11, GNAI2, GNAI3, GNAQ, GRB2, HRAS, IRS1, ITPR1, ITPR2, ITPR3, JAK2, JUNB, KRAS, SHC4, MAP3K1, ATF4, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, SHC3, PLCG2, PRKACB, PRKACG, PRKCB, PRKCG, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, PTK2, MAPK12, MAP2K4, SHC1, CREB3L2, SOS2, SST, SSTR3, SSTR5, STAT5A, STAT5B, CACNA1C, CACNA1D, CREB3L3, IRS4, PIK3R3, SOCS1, IRS2, SOCS2, SOCS3, BCAR1, CREB5, ADCY1, ADCY3, CREB1, CREB3L4, PIK3CB, PLCG1, POU1F1, PRKACA, PRKCA |
| Hedgehog signaling pathway | CSNK1A1L, EVC2, CSNK1A1, CSNK1D, CSNK1E, CSNK1G2, CSNK1G3, GRK2, GRK3, MEGF8, EVC, FBXW11, MGRN1, GPR161, GAS1, GLI1, GLI2, GLI3, IHH, KIF7, LRP2, ARRB2, DHH, CDON, SUFU, CSNK1G1, PRKACB, PRKACG, PTCH1, CCND1, HHIP, SMURF2, SMO, SPOP, CUL1, PTCH2, BTRC, PIK3CB, SRC, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, PRKACA, SMURF1, CUL3, CCND2 |
| Hematopoietic cell lineage | CR1L, CR2, CSF1R, CSF3, CSF3R, CD55, DNTT, EPO, EPOR, FCER2, FLT3LG, GP1BA, GP1BB, GP9, ANPEP, GYPA, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IL1R1, IL3, IL4R, IL5RA, IL7, IL7R, IL9R, IL11RA, ITGA2, ITGA2B, ITGA3, ITGAM, ITGB3, MME, TFRC, THPO, TNF, CD1C, CD1E, CD2, CD3E, CD3G, CD4, CD5, CD7, CD8B, CD19, MS4A1, CD22, CD33, CD34, CD36, CD37, CD38, CD59, CSF1, FLT3, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL1A, IL1B, IL2RA, IL4, IL5, IL6, IL6R, IL11, ITGA6, ITGA4, ITGA5, KIT, KITLG, TNF, IL1R2, CD1D, CD8A, CD9, CD44, CD24, CD1D |
| Hepatitis B | AKT3, CDKN1A, TAB1, CREB3, TIRAP, ATF2, CREBBP, ATF6B, TICAM1, DDB1, DDB2, DDX3X, E2F2, E2F3, EGR2, EGR3, ELK1, EP300, AKT2, PTK2B, TAB2, FOS, GRB2, TBK1, HRAS, HSPG2, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, IRAK1, IRF3, IRF7, JAK1, JAK2, JAK3, KRAS, SMAD3, SMAD4, MAP3K1, MYD88, ATF4, NFATC1, NFATC2, NFATC3, NFATC4, NFKBIA, IRAK4, PIK3CD, PIK3R1, PIK3R2, ATP6AP1, PRKCB, PRKCG, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, MAVS, RELA, MAPK12, BID, IFIH1, MAP2K4, CREB3L2, SOS2, BRAF, STAT2, STAT5A, STAT5B, STAT6, MAP3K7, TGFB2, TGFBR1, TGFBR2, TLR3, TNF, TP53, TRAF3, TRAF6, YWHAB, YWHAZ, CASP10, CREB3L3, PIK3R3, IKBKG, FADD, CCNE1, CCNE2, CREB5, IKBKE, CDK2, YWHAQ, CREB1, MAPK14, TICAM1, CREB3L4, E2F1, AKT1, APAF1, BIRC5, IFNA1, FAS, FASLG, IL6, CXCL8, JUN, MMP9, MYC, NFKB1, PCNA, PIK3CA, PIK3CB, CYCS, PRKCA, MAPK1, MAPK3, MAPK8, BAD, BAX, RAF1, RB1, BCL2, SOS1, SRC, STAT1, STAT3, STAT4, TGFB1, TGFB3, TLR2, TLR4, TNF, TP53, TYK2, VDAC3, CASP3, CASP8, CASP9, CCNA2, CCNA1, CREB1, TIC |
| Hepatitis C | AKT3, CDK6, CDKN1A, IRF9, CLDN16, CLDN4, CLDN7, CLDN23, TICAM1, E2F2, E2F3, EIF2S1, AKT2, CLDN14, CLDN15, CLDN17, EIF2AK1, GRB2, TBK1, HRAS, IFIT1, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, CXCL10, EIF3E, IRF3, IRF7, JAK1, KRAS, LDLR, MX1, NFKBIA, OAS1, OAS2, CLDN18, PIK3CD, PIK3R1, PIK3R2, PPARA, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, MAP2K1, MAP2K2, EIF2AK2, MAVS, CCND1, RELA, RNASEL, BID, SOS2, BRAF, STAT2, TLR3, CLDN5, TNF, TP53, TRAF2, TRAF3, TRAF6, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, PIK3R3, IKBKG, PIAS1, TRADD, FADD, CFLAR, SOCS3, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, RSAD2, EIF2AK3, SCARB1, IKBKE, CD81, NR1H3, CDK2, PSME3, YWHAQ, TICAM1, CTNNB1, E2F1, EGF, EGFR, AKT1, GSK3B, APAF1, IFNA1, IFNAR2, IFNG, FAS, FASLG, MYC, NFKB1, CLDN11, PIK3CA, PIK3CB, CYCS, PPP2CB, MAPK1, MAPK3, BAD, BAK1, BAX, RAF1, RB1, RXRA, SOS1, STAT1, STAT3, TNF, TNFRSF1A, TP53, TYK2, CASP3, CASP8, CASP9, PSME3, TICAM1, PIK3CB, PPP2CB, RXRA |
| Hepatocellular carcinoma | AKT3, CDK6, CDKN1A, APC2, TXNRD2, GSTO2, CSNK1A1L, CSNK1A1, DDB2, GADD45A, NQO1, DVL1, DVL2, DVL3, E2F2, E2F3, ARID2, ELK1, AKT2, FRAT2, FZD2, GAB1, SHC2, GRB2, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, APC, HRAS, KRAS, SHC4, LRP6, LRP5, SMAD2, SMAD3, SMAD4, MGST2, MGST3, GADD45B, LEF1, WNT16, ACTL6B, POLK, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, WNT4, PBRM1, PHF10, PRKCB, PRKCG, MAP2K1, MAP2K2, ARID1B, CCND1, BCL2L1, RPS6KB1, RPS6KB2, SHC1, SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD3, SMARCE1, SOS2, BRAF, TCF7, TERC, TGFA, TGFB2, TGFBR1, TGFBR2, ACTG1, TP53, TXNRD1, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, WNT5B, DPF1, ARID1A, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, PIK3R3, ACTL6A, WNT3A, GSTO1, KEAP1, CDKN2A, GADD45G, CTNNB1, E2F1, EGFR, AKT1, MTOR, BRD7, GSK3B, GSTM1, GSTM3, GSTP1, GSTT1, HGF, HMOX1, IGF1R, IGF2, MET, MGST1, MYC, NFE2L2, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, BAD, PTEN, BAK1, BAX, RAF1, RB1, ACTB, SOS1, T |
| Herpes simplex virus 1 infection | AKT3, ZNF737, ZNF316, ZNF256, ALYREF, ZNF443, ZNF267, IRF9, TAB1, NXF1, ZNF211, ZNF234, ZNF273, ZNF460, ZNF268, ZNF275, SRSF8, CGAS, ZNF554, ZNF689, ZNF354B, ZNF641, ZNF543, ZNF440, ZNF57, ZNF684, ZNF786, ZFP92, ZFP28, ZFP90, ZNF597, ZNF785, ZNF688, ZNF480, ZNF418, ZNF417, ZNF548, ZNF563, ZNF420, ZNF565, ZNF583, TICAM1, ZNF599, ZNF558, ZNF714, ZNF555, ZNF569, ZNF570, ZNF595, ZNF746, ZFP1, ZNF519, ZNF610, ZNF600, ZNF320, ZNF550, ZNF846, ZNF791, ZNF564, ZNF709, ZNF114, ZNF567, ZNF383, ZNF540, ZNF679, ZNF596, ZNF169, ZNF721, ZNF675, EIF2S1, EIF2B1, EIF4EBP1, ZNF627, ZNF585A, ZNF584, AKT2, ZNF25, ZFP30, TAB2, ZNF620, ZNF718, ZNF549, ZNF324, ZNF473, ZNF337, ZNF285, EIF2AK1, ZNF544, ZNF547, ZNF615, ZNF841, ZNF763, ZFP82, ZNF875, ZNF619, ZNF454, TBK1, HCFC2, HCFC1, ZNF354C, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, BIRC2, ZNF546, ZFP69, STING1, ZNF680, ZNF517, ZNF677, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, ZNF879, IFNGR1, IFNGR2, ZNF530, ZNF713, ZNF429, ZNF233, IKBKB, IRAK1, IRF3, IRF7, ITGB3, JAK1, JAK2 |
| HIF-1 signaling pathway | AKT3, CDKN1A, CDKN1B, EGLN2, CREBBP, CYBB, EDN1, EIF4E, EIF4EBP1, ENO2, ENO3, EP300, EPO, AKT2, ALDOA, ALDOB, ALDOC, ANGPT1, ANGPT2, MKNK2, HK2, HK3, IFNGR1, IFNGR2, INS, LDHB, LTBR, ANGPT4, PDHA1, PDHB, PDK1, PFKL, PFKM, PFKP, PIK3CD, PIK3R1, PIK3R2, PLCG2, EGLN1, PRKCB, PRKCG, MAP2K1, MAP2K2, RELA, RPS6, RPS6KB1, RPS6KB2, ELOC, ELOB, TEK, TFRC, VHL, HKDC1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CUL2, PIK3R3, MKNK1, LDHAL6B, EIF4E2, RBX1, EGF, EGFR, ENO1, ERBB2, AKT1, FLT1, MTOR, GAPDH, HIF1A, HK1, HMOX1, IFNG, IGF1, IGF1R, IL6, IL6R, INSR, ENO4, LDHA, LDHC, NFKB1, NOS2, NOS3, SERPINE1, PDHA2, PFKFB3, PGK1, PGK2, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, BCL2, SLC2A1, STAT3, TF, TIMP1, TLR4, VEGFA, HK1, ENO4, PDHA2, PFKFB3, PIK3CB, PLCG1, PRKCA, SLC2A1 |
| Hippo signaling pathway | PATJ, APC2, YAP1, FRMD6, WTIP, CSNK1D, CSNK1E, CCN2, CTNNA1, CTNNA2, GDF7, AMOT, RASSF6, DLG1, DLG2, DLG3, DLG4, DVL1, DVL2, DVL3, FGF1, WWC1, FBXW11, CRB1, SCRIB, FZD2, WWTR1, LATS2, BBC3, GLI2, CRB2, CTNNA3, APC, BIRC2, ID2, ITGB2, AREG, LLGL2, LLGL1, SMAD2, SMAD3, SMAD4, PARD6A, LEF1, WNT16, WNT4, PPP1CB, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, MOB1A, PPP2R2D, PRKCZ, PARD3, CCND1, SAV1, BMP2, BMP5, BMP6, BMPR1A, STK3, TCF7, TEAD1, TEAD4, TEAD3, TGFB2, TGFBR1, TGFBR2, ACTG1, TP53BP2, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, FZD5, FZD3, FRMD1, WNT10A, WNT5B, GDF5, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, PARD6G, PARD6B, TEAD2, AJUBA, NKD1, NKD2, BTRC, CCND3, WNT3A, LIMD1, LATS1, DLG5, MOB1B, BAX, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PIK3CA, PIK3CB, CYCS, BAX, RAF1, JUN, MYC, PIK3CA, PIK3CB, CYCS, BAX, RAF1, SRC, MYC, PIK3CA, PIK3CB, CYCS, BAX, RAF1, HLA-A, HLA-B, HLA-C, BMP8A, SMAD1, PPP1CC, PPP2CB, BMP8B |
| Hippo signaling pathway - multiple species | YAP1, FRMD6, WTIP, CSNK1E, RASSF6, WWC1, WWTR1, LATS2, DCHS2, MOB1A, SAV1, STK3, TEAD1, TEAD4, TEAD3, FRMD1, TEAD2, AJUBA, DCHS1, LIMD1, LATS1, MOB1B, RASSF2, HLA-DPB1, HLA-DQA1, HLA-DQB1 |
| Histidine metabolism | FTCD, UROC1, CARNMT1, AMDHD1, ALDH2, ALDH1A3, ALDH3B1, ALDH3B2, ALDH9A1, ALDH3A2, AOC1, HAL, HNMT, ASPA, CNDP2, CNDP1, PIK3CA |
| Homologous recombination | RAD50, TOPBP1, RAD54B, BABAM1, MRE11, UIMC1, POLD1, POLD2, POLD4, BARD1, RAD51C, RAD51B, RAD51D, RAD52, RBBP8, RPA1, RPA2, RPA3, BLM, SSBP1, XRCC2, XRCC3, PALB2, SEM1, MUS81, BRIP1, ABRAXAS1, RAD54L, TOP3B, BABAM2, RAF1, JUN, PIK3CA, PIK3CB, RAF1, JUN, PIK3CA, PIK3CB, POLD3, EME1, RAD51 |
| Human cytomegalovirus infection | AKT3, CDK6, CDKN1A, CREB3, GNB5, ADCY5, ADCY6, AKAP13, ADCY7, ADCY8, ADCY9, CGAS, CCR1, CCR3, ATF2, ATF6B, CRK, CRKL, CALML6, E2F2, E2F3, ADCY4, EIF4EBP1, ELK1, AKT2, PTK2B, ARHGEF12, GNA11, GNA12, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRB2, TBK1, HLA-F, HRAS, STING1, IFNA2, IFNA8, IFNA10, IFNA14, IKBKB, IL1R1, CXCR2, IL10RA, IL10RB, IRF3, ITGB3, ITPR1, ITPR2, ITPR3, JAK1, KRAS, CCL3L3, ATF4, NFATC1, NFATC2, NFATC3, NFATC4, NFKBIA, PDGFRA, GNG13, CALML5, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, GNG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PRKCB, PRKCG, GNG12, MAPK11, MAPK13, MAP2K1, MAP2K2, MAP2K6, PTGER1, PTGER2, PTGER3, PTGER4, PTK2, PXN, RAC1, RAC2, RAC3, GNB4, CCND1, RELA, RHEB, ROCK1, RPS6KB1, RPS6KB2, MAPK12, CCL2, CCL3, BID, CXCL12, CREB3L2, SOS2, TAP1, TAP2, TAPBP, TNF, TP53, TRAF2, TRAF5, TSC1, TSC2, CXCR4, CALM2, CALM3, CALML3, CALR, CREB3L3, PIK3R3, IKBKG, TRADD, FADD, ARHGEF1, CALML4, GNG8, ROCK2, BCAR1, CREB5, ARHGEF11, CDKN2A, GNA |
| Human immunodeficiency virus 1 infection | AKT3, APOBEC3A_B, PAK4, TAB1, GNB5, CFL2, CGAS, AP1S1, AP1S3, CRK, CRKL, AP1B1, CALML6, AP1G1, DDB1, APOBEC3F, AKT2, PTK2B, TAB2, FBXW11, FOS, SAMHD1, APOBEC3C, GNA11, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, TBK1, HLA-F, HRAS, STING1, IFNA2, IFNA8, IFNA10, IFNA14, IKBKB, IRAK1, IRF3, ITPR1, ITPR2, ITPR3, KRAS, LIMK1, MYD88, NFATC1, NFATC2, NFATC3, NFATC4, NFKBIA, PAK3, IRAK4, GNG13, CALML5, PIK3CD, PIK3R1, PIK3R2, PLCG2, GNG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB, PRKCG, GNG12, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, PAK6, PAK5, PTK2, PXN, RAC1, RAC2, RAC3, GNB4, RELA, BCL2L1, APOBEC3G, RPS6KB1, RPS6KB2, MAPK12, BID, SKP1, BST2, MAP3K7, TAP1, TAP2, TAPBP, ELOC, ELOB, TNF, TRAF2, TRAF5, TRAF6, CXCR4, CALM2, CUL5, CALM3, CALML3, CALR, CUL1, PIK3R3, IKBKG, TRIM5, CCNB3, TRADD, FADD, AP1S2, AP1G2, AP1M1, BTRC, CD3E, CD3G, CALML4, CD247, CD4, GNG8, APOBEC3B, DCAF1, RBX1, CFL1, CHEK1, CCR5, MAPK14, AKT1, MTOR, GNAI1, GNAO1, PD |
| Human papillomavirus infection | AKT3, BCAP31, PATJ, CDK6, CDKN1A, CDKN1B, APC2, TCIRG1, LAMC3, IRF9, TADA3, CREB3, CHAD, CHD4, CSNK1A1L, ATP6V1G3, COL1A2, COL2A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COL9A2, COL9A3, COMP, COL6A6, CREBBP, CSNK1A1, TICAM1, ATP6V0E2, DLG1, DLG2, DLG3, JAG1, DVL1, DVL2, DVL3, EIF4EBP1, EP300, AKT2, ITGA11, UBR4, HEY1, HEY2, SCRIB, ATP6V1C2, FZD2, COL6A5, TUBG2, GRB2, TBK1, HDAC2, HLA-F, APC, HRAS, HES1, TNC, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, RBPJ, IKBKB, IRF1, IRF3, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JAK1, KRAS, TBPL2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, LFNG, LLGL2, LLGL1, MFNG, MX1, NFX1, NOTCH1, NOTCH3, NOTCH4, ATP6V0A4, PARD6A, ATP6V1D, WNT16, PDGFRB, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, PIK3CD, PIK3R1, PIK3R2, PKM, ATP6V0B, ATP6V1G2, ATP6V0A1, ATP6AP1, WNT4, HES2, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, HES6, MAML3, PRKACB, PR |
| Human T-cell leukemia virus 1 infection | AKT3, CDKN1A, CDKN2B, CDKN2C, CREB3, KAT5, PTTG2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, TNFRSF13C, ATF2, CREBBP, ATF6B, DLG1, E2F2, E2F3, EGR1, EGR2, ADCY4, ELK1, ELK4, EP300, AKT2, ETS1, ETS2, CRTC1, FOS, CDC26, KAT2A, GPS2, SLC25A4, SLC25A5, SLC25A6, ANAPC2, ANAPC4, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, HRAS, XIAP, IKBKB, IL1R1, IL2RB, IL2RG, IL15, IL15RA, ITGAL, ITGB2, JAK1, JAK3, KRAS, TBPL2, LCK, LTA, LTBR, MAD2L1, SMAD2, SMAD3, SMAD4, MAP3K1, MAP3K3, MSX1, MSX2, ATF4, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIA, NFYB, ANAPC5, ANAPC7, ANAPC11, PIK3CD, PIK3R1, PIK3R2, POLB, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, VAC14, MAPK9, MAPK10, MAP2K1, MAP2K2, RAN, CCND1, RELA, RELB, BCL2L1, MAP2K4, ANAPC1, CREB3L2, CRTC3, SPI1, SRF, STAT5A, STAT5B, BUB1B, TGFB2, TGFBR1, TGFBR2, TLN1, TNF, TP53, VDAC2, XPO1, ZFP36, CALR, CANX, TRRAP, SLC25A31, TLN2, MAD1L1, CREB3L3, RANBP3, PIK3R3, IKBKG, CDC23, NRP1, KAT2B, CDC16, CCND3, CCNE1, MAP3K14, CCNE2, CD3E, CD3G, BUB3, CD4, CD40, CREB5, ESP |
| Huntington disease | NDUFC2-KCTD14, PPIF, ACTR1B, ACTR1A, DNAL4, PSMD14, TUBB4A, TUBB4B, ATP5PD, CREB3, DCTN2, DCTN6, PPARGC1A, UQCR11, ADRM1, DCTN3, TUBA3E, TUBA3D, AP2M1, AP2S1, CLTA, CLTB, CLTC, COX6B2, NDUFA11, DNAH14, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, CREBBP, PSMA8, DNAH2, KLC3, CYC1, AP2A1, AP2A2, AP2B1, COX7B2, DLG4, DNAH6, DNAH8, DNAH10, TUBB, EP300, ERN1, ATG2A, RCOR1, WIPI2, UQCRQ, BBC3, GNAQ, GPX2, GPX3, GPX7, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2B, SLC25A4, GRM5, SLC25A5, SLC25A6, UQCR10, NRBF2, HTT, HDAC2, PIK3R4, COX8C, TUBB8, ITPR1, NDUFS7, KCNJ10, KIF5A, KIF5B, KLC1, TBPL2, MAP3K5, MAP3K10, UQCRHL, COX2, ND1, ND4L, ND5, ND6, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ATP5F1B, ATP5F1C, DCTN4, ATP5F1D, ATP5F1E, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PF, PIK3C3, PLCB2, PLCB3, |
| Hypertrophic cardiomyopathy | CACNG3, CACNG2, DAG1, DES, DMD, AGT, EDN1, EMD, ITGA11, CACNG4, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, MYBPC3, MYH6, MYL2, MYL3, ATP2A1, ATP2A2, ATP2A3, PRKAG2, PRKAA2, PRKAB1, CACNA2D3, CACNG8, CACNG7, CACNG6, RYR2, SGCA, SGCB, SGCD, SLC8A2, SLC8A1, SLC8A3, ACTC1, TGFB2, ACTG1, TNF, TPM2, TPM3, TPM4, TTN, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, ITGA10, ITGA8, CACNA2D2, CACNA2D4, ACE, IGF1, IL6, ITGA6, ITGA4, ITGA5, ITGAV, ITGB1, LAMA2, MYH7, PRKAA1, ACTB, TGFB1, TGFB3, TNF, TPM1, CACNA1S, CACNA2D1, LAMA2, PRKAA1 |
| IL-17 signaling pathway | TRAF3IP2, IL17F, CSF3, DEFB4A, MAPK15, TAB2, FOS, FOSB, IL17RA, TAB3, IL17C, TBK1, CXCL1, CXCL2, CXCL3, USP25, IKBKB, IL13, CXCL10, JUND, MMP13, NFKBIA, ANAPC5, IL17D, MAPK4, MAPK6, MAPK7, MAPK11, MAPK9, MAPK10, MAPK13, RELA, S100A7, S100A8, MAPK12, CCL2, CCL7, CCL11, CCL17, CCL20, CXCL6, CXCL5, IL25, MAP3K7, TNF, HSP90B1, TRAF2, TRAF3, TRAF5, TRAF6, IKBKG, TRADD, FADD, TRAF4, IKBKE, MAPK14, ELAVL1, GSK3B, HSP90AA1, HSP90AB1, IFNG, IL1B, IL4, IL5, IL6, CXCL8, IL17A, JUN, LCN2, MMP9, NFKB1, IL17RB, MAPK1, MAPK3, MAPK8, PTGS2, S100A9, TNF, TNFAIP3, MUC5B, CASP3, CASP8, HSP90AB1, TNFAIP3 |
| Inflammatory bowel disease | IL17F, IL23R, GATA3, TBX21, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IFNGR1, IFNGR2, IL2RG, IL4R, IL12RB1, IL12RB2, IL13, SMAD2, SMAD3, MAF, NFATC1, IL21R, RELA, RORA, RORC, NOD2, STAT6, TGFB2, TLR5, TNF, IL18RAP, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, IL1A, IL1B, IL2, IL4, IL5, IL6, IL10, IL12A, IL17A, IL18, JUN, NFKB1, FOXP3, IL23A, IL21, STAT1, STAT3, STAT4, TGFB1, TGFB3, TLR2, TLR4, TNF |
| Inflammatory mediator regulation of TRP channels | ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CYP2J2, CYP4A11, TRPV3, CALML6, ADCY4, GNAQ, HRH1, HTR2B, HTR2C, IL1R1, IL1RAP, ITPR1, ITPR2, ITPR3, ASIC2, ASIC1, P2RY2, TRPV2, CALML5, PIK3CD, PIK3R1, PIK3R2, PLA2G4A, PLCB2, PLCB3, PLCG2, PPP1CB, ASIC4, PRKACB, PRKACG, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K3, MAP2K6, PTGER2, PTGER4, BDKRB1, BDKRB2, MAPK12, TRPV1, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PIK3R3, PLA2G4C, TRPA1, CALML4, ASIC3, ADCY1, ADCY2, ADCY3, MAPK14, F2RL1, PLCB1, GNAS, HTR2A, IGF1, IL1B, NGF, NTRK1, PIK3CA, PIK3CB, PLCG1, PPP1CC, PRKACA, PRKCA, MAPK8, TRPV4, SRC, TRPM8, CALM1, PLA2G6, ADCY1, ADCY3, HTR2A, PIK3CB, PLCG1, PPP1CC, PRKACA, PRKCA, TRPV4, TRPM8, CALM1 |
| Influenza A | AKT3, BCL2L2-PABPN1, CDK6, CALCOCO2, ADAR, IRF9, NXF1, CPSF4, HNRNPUL1, NLRP3, CREBBP, TICAM1, EIF2S1, EP300, AKT2, TPSD1, KPNA6, SLC25A4, NXT1, PYCARD, TBK1, SLC25A5, SLC25A6, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, DNAJB1, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, IKBKB, CXCL10, IRF3, IRF7, JAK1, JAK2, KPNA1, KPNA2, KPNA5, CIITA, MX1, MYD88, NFKBIA, NFKBIB, NUP98, OAS1, OAS2, IRAK4, TLR7, PIK3CD, PIK3R1, PIK3R2, PLG, PML, PRKCB, NXT2, MAP2K1, MAP2K2, EIF2AK2, DNAJC3, PRSS3, TMPRSS4, MAVS, RELA, RNASEL, CCL2, BID, IFIH1, TPSB2, STAT2, TLR3, ACTG1, TMPRSS2, TNF, TPSAB1, TRAF3, XPO1, TRIM25, NLRX1, PABPN1, SLC25A31, RAE1, PIK3R3, IKBKG, TRADD, RAB11A, FADD, TNFRSF10B, TNFRSF10A, CCND3, SOCS3, RSAD2, RAB11B, TMPRSS11D, IKBKE, TICAM1, AKT1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, APAF1, ICAM1, IFNA1, IFNAR2, IFNG, FAS, IL1A, IL1B, FASLG, IL6, CXCL8, IL12A, IL18, NFKB1, PIK3CA, PIK3CB, CYCS, PRKCA, MAPK1, MAPK3, NXF2, BAK1, BAX, RAF1, ACTB, CCL5, STAT1, TLR4, TNF, TNFRSF1A, TYK2, VDAC |
| Inositol phosphate metabolism | CDIPT, PIKFYVE, INPP5F, SACM1L, PLCH1, PIP5K1C, IPMK, IMPA1, IMPA2, INPP1, INPP4A, INPP5A, INPP5B, INPP5D, ITPK1, ITPKA, ITPKB, ALDH6A1, MTM1, OCRL, PLCE1, ISYNA1, INPP5K, PIK3C2A, PIK3C2B, PIK3C3, PIK3CD, PIK3CG, PI4KA, PI4KB, PIP4K2A, PLCB2, PLCB3, PLCD1, PLCG2, BPNT2, PI4K2B, PI4K2A, MTMR8, INPP5E, MTMR14, IPPK, TPI1, PIP4K2C, PIP5K1A, PIP5K1B, PIP4K2B, PLCD4, MTMR1, INPP4B, SYNJ1, SYNJ2, MTMR3, MTMR6, MTMR7, MTMR4, MINPP1, PLCH2, MCL1, MYC, PIK3CA, PIK3CB, RAF1, PLAU, JUN, PIK3CB, PLCG1, MTMR2 |
| Insulin resistance | AKT3, CREB3, PPARGC1A, SLC27A5, SLC27A4, SLC27A3, SLC27A2, PPARGC1B, CPT1A, CPT1B, AGT, AKT2, MLXIP, GFPT1, GYS1, GYS2, ACACB, IKBKB, INS, IRS1, SLC27A1, NFKBIA, PCK2, PRKAG2, PDPK1, PIK3CD, PIK3R1, PIK3R2, PPARA, PPP1CB, PPP1R3C, PPP1R3D, PRKAA2, PRKAB1, PRKCB, PRKCD, PRKCE, PRKCQ, PRKCZ, MAPK9, MAPK10, PTPN1, TRIB3, G6PC2, PTPRF, PYGB, PYGL, PYGM, RELA, RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, CREB3L2, SLC2A4, SREBF1, MLX, TNF, NR1H2, PPP1R3B, CREB3L3, OGT, PIK3R3, IRS2, SOCS3, CD36, CREB5, TBC1D4, NR1H3, OGA, CREB1, CREB3L4, AKT1, FOXO1, MTOR, GSK3B, IL6, INSR, NFKB1, NOS3, PIK3CA, PIK3CB, PPP1CC, PTPA, PRKAA1, MAPK8, PTEN, PTPN11, SLC2A1, STAT3, TNF, TNFRSF1A, G6PC3, GFPT2, CREB1, CREB3L4, PIK3CB, PPP1CC, PTPA, PRKAA1, SLC2A1, GFPT2 |
| Insulin secretion | CREB3, RAPGEF4, ADCY5, ADCY6, ADCY7, CHRM3, ADCY8, ADCY9, ADCYAP1R1, ATF2, ATF6B, GPR119, ADCY4, GCK, KCNMB3, KCNMB4, GLP1R, GNA11, GNAQ, FFAR1, INS, PDX1, ITPR3, KCNMA1, KCNMB1, KCNN1, KCNN2, KCNN3, KCNN4, ATF4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, PLCB2, PLCB3, TRPM4, PRKACB, PRKACG, PRKCB, PRKCG, RYR2, CREB3L2, SNAP25, ABCC8, CACNA1C, CACNA1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB3L3, CCK, CCKAR, CREB5, RIMS2, ADCY1, ADCY2, ADCY3, ADCYAP1, CREB1, CREB3L4, KCNU1, PLCB1, GNAS, PRKACA, PRKCA, RAB3A, SLC2A1, STX1A, VAMP2, CACNA1S, ADCY1, ADCY3, CREB1, CREB3L4, KCNU1, PRKACA, PRKCA, RAB3A, SLC2A1, STX1A, VAMP2 |
| Insulin signaling pathway | AKT3, FLOT1, SORBS1, SH2B2, PPARGC1A, SOCS4, CRK, CRKL, CALML6, EIF4E, EIF4EBP1, ELK1, AKT2, FASN, FBP1, EXOC7, RHOQ, SHC2, GCK, MKNK2, GRB2, RAPGEF1, GYS1, GYS2, HK2, ACACA, HK3, ACACB, HRAS, IKBKB, INS, INPP5A, IRS1, KRAS, SHC4, PCK2, PDE3B, PRKAG2, PDPK1, INPP5K, CALML5, PHKA2, PHKB, PHKG1, PHKG2, PIK3CD, PIK3R1, PIK3R2, PKLR, SHC3, PPP1CB, PPP1R3C, PPP1R3D, PRKAA2, PRKAB1, PRKACB, PRKACG, PRKAR1B, PRKAR2A, PRKAR2B, PRKCZ, MAPK9, MAPK10, MAP2K1, MAP2K2, RPTOR, PTPN1, G6PC2, PTPRF, PYGB, PYGL, PYGM, RHEB, RPS6, RPS6KB1, RPS6KB2, SHC1, SLC2A4, SOS2, SREBF1, BRAF, TSC1, TSC2, PPP1R3B, HKDC1, CALM2, CALM3, CALML3, IRS4, PIK3R3, MKNK1, SOCS1, IRS2, CBL, CBLB, FBP2, SOCS2, SOCS3, CALML4, TRIP10, EIF4E2, AKT1, FOXO1, FLOT2, MTOR, GSK3B, HK1, INSR, LIPE, PIK3CA, PIK3CB, PPP1CC, PRKAA1, PRKACA, PRKAR1A, MAPK1, MAPK3, MAPK8, BAD, RAF1, SOS1, CALM1, G6PC3, FLOT2, HK1, PIK3CB, PPP1CC, PRKAA1, PRKACA, PRKAR1A, CALM1 |
| Intestinal immune network for IgA production | TNFSF13B, TNFRSF13C, ICOSLG, TNFRSF13B, CCR10, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IL15, IL15RA, ITGB7, LTBR, PIGR, CCL28, TNFRSF17, CXCL12, CXCR4, MADCAM1, TNFSF13, MAP3K14, CD28, CD80, CD86, CD40, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL2, IL4, IL5, IL6, IL10, ITGA4, TGFB1 |
| JAK-STAT signaling pathway | AKT3, STAM2, CDKN1A, IRF9, PIAS3, IL24, CISH, IL22RA2, SOCS4, CNTF, CNTFR, CREBBP, CSF2RB, CSF3, CSF3R, CSH1, CSH2, CTF1, IL23R, EP300, EPO, EPOR, AKT2, FHL1, GFAP, GH2, GHR, IFNL3, IFNL1, GRB2, IL19, SOCS7, AOX1, HRAS, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, IFNW1, IL2RB, IL2RG, IL3, IL4R, IL5RA, IL7, IL7R, IL9R, IL10RA, IL10RB, IL11RA, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, JAK1, JAK2, JAK3, LIFR, MPL, OSM, IL20, IL21R, PDGFA, PDGFB, PDGFRA, PIAS4, PDGFRB, PIK3CD, PIK3R1, PIK3R2, IL17D, IL20RB, PTPN2, PTPN6, IL22RA1, CCND1, BCL2L1, CRLF2, SOS2, STAT2, STAT5A, STAT5B, STAT6, THPO, STAM, PIK3R3, TSLP, PIAS1, SOCS1, SOCS2, CCND3, SOCS3, PIAS2, OSMR, SOCS6, IL27RA, SOCS5, MYC, PIK3CA, PIK3CB, CYCS, BAX, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, PIK3CA, PIK3CB, BAX, RAF1, PIK3CA, PIK3CB, MET, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CYCS, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, JUN, JUN, PIK3CA, PIK3CB, MET, PIK3CA, PIK3CB, BAX, RAF1, SRC, PIK3CB, CCND2 |
| Kaposi sarcoma-associated herpesvirus infection | AKT3, CDK6, CDKN1A, IRF9, GNB5, GABARAP, GABARAPL2, CCR1, CCR3, CCR4, CD200R1, CREBBP, PIK3R6, TICAM1, CALML6, RCAN1, E2F2, E2F3, EP300, AKT2, FGF2, FOS, PIK3R5, GABARAPL1, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, ANGPT2, TBK1, CXCL1, CXCL2, CXCL3, HCK, HLA-F, HRAS, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IKBKB, IRF3, IRF7, ITPR1, ITPR2, ITPR3, JAK1, JAK2, KRAS, LYN, MICB, NFATC1, NFATC2, NFATC3, NFATC4, NFKBIA, PDGFB, GNG13, CALML5, PIK3C3, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PLCG2, GNG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, GNG12, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K6, MAP2K7, EIF2AK2, PREX1, RAC1, GNB4, CCND1, RELA, RPS27A, MAPK12, BID, MAP2K4, ATG3, STAT2, SYK, TLR3, TP53, TRAF2, TRAF3, UBA52, UBB, UBC, ZFP36, CALM2, CALM3, CALML3, PIK3R3, IKBKG, BECN1, TRADD, FADD, CALML4, CD86, GNG8, IKBKE, CLEC2B, CCR5, CREB1, MAPK14, TICAM1, CTNNB1, E2F1, AKT1, MTOR, GSK3B, HIF1A, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, ICAM1, IFNA1, IFNAR2, FAS, IL6, IL6ST, CXCL8, JUN, MYC |
| Legionellosis | HBS1L, CLK1, CR1L, EEF1A1, EEF1A2, EEF1G, PYCARD, CXCL1, CXCL2, CXCL3, HSPA1A, HSPA6, HSPA8, ITGAM, ITGB2, ARF1, MYD88, NAIP, NFKB2, NFKBIA, SAR1B, SAR1A, CLK4, RAB1A, RELA, BNIP3, TLR5, TNF, RAB1B, CASP7, SEC22B, APAF1, HSF1, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPD1, IL1B, IL6, CXCL8, IL12A, IL18, NFKB1, CYCS, TLR2, TLR4, TNF, C3, VCP, CASP1, CASP3, CASP8, CASP9, VCP |
| Leishmaniasis | TAB1, CR1L, CYBA, CYBB, EEF1A1, EEF1A2, ELK1, FCGR2A, FCGR3B, TAB2, FOS, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IFNGR1, IFNGR2, IRAK1, ITGAM, ITGB2, JAK1, JAK2, MYD88, NCF4, NFKBIA, NFKBIB, IRAK4, PRKCB, MAPK11, MAPK13, PTPN6, RELA, MAPK12, MARCKSL1, NCF1, MAP3K7, TGFB2, TNF, TRAF6, FCGR2C, MAPK14, FCGR3A, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, IL1A, IL1B, IL4, IL10, IL12A, ITGA4, ITGB1, JUN, NFKB1, NOS2, MAPK1, MAPK3, PTGS2, STAT1, TGFB1, TGFB3, TLR2, TLR4, TNF, C3 |
| Leukocyte transendothelial migration | CDH5, MYL12B, RAPGEF3, VAV3, MYL12A, CLDN16, RAPGEF4, CLDN4, CLDN7, CLDN23, CTNNA1, CTNNA2, CTNND1, CYBA, CYBB, PTK2B, CLDN14, CLDN15, CLDN17, GNAI2, GNAI3, ARHGAP35, CTNNA3, ITGAL, ITGAM, ITGB2, ITK, ARHGAP5, RHOH, AFDN, MSN, MYL2, MYL5, NCF4, F11R, CLDN18, PECAM1, PIK3CD, PIK3R1, PIK3R2, PLCG2, PRKCB, PRKCG, MAPK11, MAPK13, PTK2, PXN, JAM2, RAC1, RAC2, RAP1B, ROCK1, MAPK12, CXCL12, SIPA1, NCF1, THY1, ACTG1, CLDN5, TXK, VASP, VAV1, VAV2, VCAM1, VCL, CXCR4, ACTN4, RASSF5, CD99L2, JAM3, PIK3R3, ACTN1, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, ESAM, MYL10, ROCK2, BCAR1, MAPK14, CTNNB1, GNAI1, ICAM1, ITGA4, ITGB1, RHOA, CD99, MMP2, MMP9, CLDN11, PIK3CA, PIK3CB, PLCG1, PRKCA, PTPN11, RAP1A, ACTB, EZR, CDC42, RHOA, PIK3CB, PLCG1, PRKCA |
| Linoleic acid metabolism | PLAAT3, PLB1, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, PLA2G2D, PLA2G3, PLA2G1B, PLA2G4A, PLA2G5, PLA2G12A, PLA2G10, PLA2G12B, PLA2G4C, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 |
| Lipoic acid metabolism | LIAS, ACSM1, LIPT1 |
| Long-term depression | CRH, CRHR1, GNA11, GNA12, GNAI2, GNAI3, GNAQ, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GUCY1A2, GUCY1A1, GUCY1B1, HRAS, ITPR1, ITPR2, ITPR3, KRAS, LYN, PLA2G4A, PLCB2, PLCB3, PPP2CA, PPP2R1A, PPP2R1B, PRKCB, PRKCG, PRKG1, MAP2K1, MAP2K2, RYR1, BRAF, CACNA1A, PLA2G4C, GNA13, PLCB1, GNAI1, GNAO1, GNAS, IGF1, IGF1R, PPP2CB, PRKCA, MAPK1, MAPK3, RAF1, GNA13, GNA12, PPP2CB, PRKCA |
| Long-term potentiation | RAPGEF3, ADCY8, CREBBP, CALML6, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, ATF4, CALML5, PLCB2, PLCB3, PPP1CB, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PRKCB, PRKCG, MAP2K1, MAP2K2, RAP1B, RPS6KA1, RPS6KA2, BRAF, CACNA1C, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CALML4, ADCY1, PLCB1, PPP1CC, PRKACA, PRKCA, MAPK1, MAPK3, RAF1, RAP1A, CALM1, CAMK4, ADCY1, PPP1CC, PRKACA, PRKCA, CALM1 |
| Longevity regulating pathway | AKT3, CREB3, CAMKK2, PPARGC1A, EHMT2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, SESN3, ADCY4, EIF4E, EIF4EBP1, AKT2, FOXO3, APPL1, HRAS, INS, IRS1, KRAS, ATF4, ADIPOR1, PRKAG2, PIK3CD, PIK3R1, PIK3R2, PRKAA2, PRKAB1, PRKACB, PRKACG, RPTOR, RELA, RHEB, ATG101, RPS6KB1, RPS6KB2, CREB3L2, TP53, TSC1, TSC2, ADIPOR2, EHMT1, SESN2, ULK1, AKT1S1, CREB3L3, IRS4, PIK3R3, IRS2, KL, ADIPOQ, EIF4E2, ATG5, CREB5, ATG13, RB1CC1, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, AKT1, FOXO1, SIRT1, MTOR, IGF1, IGF1R, INSR, NFKB1, PIK3CA, PIK3CB, PPARG, PRKAA1, PRKACA, BAX, SOD2, STK11, TP53, CAMK4, CAT, ADCY1, ADCY3, CREB1, CREB3L4, PIK3CB, PRKAA1, PRKACA, STK11 |
| Longevity regulating pathway - multiple species | AKT3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CRYAB, ADCY4, EIF4EBP2, AKT2, FOXO3, HDAC2, FOXA2, HRAS, HSPA1A, HSPA6, HSPA8, INS, IRS1, KRAS, PRKAG2, PIK3CD, PIK3R1, PIK3R2, PRKAA2, PRKAB1, PRKACB, PRKACG, RPTOR, RPS6KB1, RPS6KB2, CLPB, AKT1S1, IRS4, PIK3R3, IRS2, ATG5, ADCY1, ADCY2, ADCY3, AKT1, FOXO1, SIRT1, MTOR, HDAC1, HSPA1A, HSPA1B, HSPA1L, HSPA2, IGF1, IGF1R, INSR, PIK3CA, PIK3CB, PRKAA1, PRKACA, SOD1, SOD2, CAT, ADCY1, ADCY3, PIK3CB, PRKAA1, PRKACA |
| Lysine degradation | AASS, EHMT2, PRDM7, HYKK, SMYD1, DLST, ECHS1, ALDH2, ALDH9A1, ALDH3A2, SETD1B, COLGALT2, GCDH, HADHA, HADH, KMT5A, KMT2A, KMT5B, AADAT, PIPOX, PLOD2, NSD3, TMLHE, DHTKD1, ASH1L, KMT2E, SMYD2, KMT2C, NSD1, NSD2, PRDM2, COLGALT1, SUV39H2, EHMT1, CAMKMT, KMT2D, SETD7, SETDB2, DOT1L, KMT5C, PHYKPL, PLOD3, PRDM6, SETD1A, KMT2B, SETDB1, RAF1, RAP1A, SRC, FYN, MET, SRC, YES1, DLD, EZH1, SMYD3 |
| Lysosome | AP3S2, TCIRG1, AP4B1, CTSC, AP3M2, AP4S1, AP1S1, AP3S1, TPP1, CLN3, CLTA, CLTB, CLTC, AP1S3, HGSNAT, CTNS, CTSB, CTSG, CTSH, CTSK, CTSL, CTSV, CTSS, CTSW, CTSZ, AP1B1, AP1G1, AGA, DNASE2, ABCA2, ARSG, GGA2, GGA3, AP4E1, ABCB9, PLA2G15, FUCA1, FUCA2, MFSD8, GALC, GALNS, GGA1, SLC17A5, AP3M1, LAMP3, GLA, GM2A, GNS, SUMF1, GUSB, IDS, IDUA, LAMP1, LAMP2, LIPA, M6PR, ARSB, MANBA, NAGA, NAGLU, NEU1, NPC1, ATP6V0A4, NAGPA, ATP6V1H, ATP6V0C, ACP2, ATP6V0B, ATP6V0A1, ATP6AP1, CTSA, LAPTM4B, PPT1, LGMN, PSAP, MCOLN1, DNASE2B, SORT1, SGSH, SLC11A1, SMPD1, LAPTM5, AP3B2, CLTCL1, HYAL3, GNPTG, AP3B1, HYAL2, CTSF, CD164, AP1S2, AP1G2, AP1M1, AP3D1, ATP6V0D1, AP4M1, NAPSA, SCARB2, LITAF, ENTPD4, CD63, LAPTM4A, NPC2, CTSD, ATP6V0A2, GAA, GBA, GLB1, HEXA, HEXB, IGF2R, ARSA, MAN2B1, ASAH1, SLC11A2, CD68, GM2A, SLC11A2 |
| Malaria | COMP, CR1L, CSF3, ACKR1, GYPA, GYPC, HBA1, HBA2, HBB, ITGAL, ITGB2, LRP1, MYD88, PECAM1, TLR9, CCL2, SDC1, SDC2, SELP, TGFB2, THBS1, THBS2, THBS3, THBS4, TNF, VCAM1, CD36, CD40, CD81, HGF, ICAM1, IFNG, IL1B, IL6, CXCL8, IL10, IL12A, IL18, MET, TGFB1, TGFB3, TLR2, TLR4, TNF |
| Mannose type O-glycan biosynthesis | RXYLT1, POMT1, FUT9, B4GAT1, LARGE2, B3GAT2, MGAT5B, B3GALNT2, FKTN, B4GALT1, B3GAT1, POMGNT1, CRPPA, FKRP, POMK, POMGNT2, B4GALT3, B4GALT2, LARGE1, CHST10, HLA-A |
| MAPK signaling pathway | AKT3, RASGRP1, RASGRP2, CACNG3, CACNG2, TAB1, MAP3K2, MAP4K1, DUSP10, RASGRP4, MAP3K8, ATF2, CRK, CRKL, CSF1R, GADD45A, DDIT3, DUSP1, DUSP2, DUSP3, DUSP5, DUSP7, DUSP8, DUSP9, EFNA1, EFNA2, EFNA3, EFNA5, EPHA2, ELK1, ELK4, ERBB3, EREG, AKT2, MECOM, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, RRAS2, MRAS, TAB2, FLNB, FLNC, FLT3LG, FLT4, FOS, MAPK8IP2, RASGRP3, FGF20, FGF21, FGF22, CACNG4, GNA12, ANGPT1, ANGPT2, MKNK2, GRB2, NR4A1, HRAS, HSPA1A, HSPA6, HSPA8, HSPB1, IKBKB, IL1R1, IL1RAP, INS, IRAK1, JUND, AREG, KRAS, STMN1, ARRB2, MAX, MEF2C, MAP3K1, MAP3K3, MAP3K4, MAP3K5, MYD88, GADD45B, ATF4, NF1, NFATC1, NFATC3, NFKB2, NGFR, NTF3, NTF4, NTRK2, IRAK4, ECSIT, TAOK3, ANGPT4, PDGFA, PDGFB, PDGFRA, PDGFRB, NLK, MAP3K20, PLA2G4A, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACB, PRKACG, PRKCB, CACNA2D3, PRKCG, GNG12, MAPK7, MAPK11, MAPK9, MAPK10, MAPK13, PDGFC, MAP2K1, MAP2K2, MAP2K3, MAP2K5, MAP2K6, MAP2K7, TAOK1, PTPN7, PTPRR, MAP4K2, RAC1, RAC2, RAC3, RAP1B, RASA1, RASA2, RASGRF1, RASGRF2, C |
| Maturity onset diabetes of the young | BHLHA15, RFX6, GCK, HHEX, MNX1, FOXA2, HNF4A, HNF4G, ONECUT1, HES1, IAPP, INS, PDX1, NEUROD1, NKX2-2, PAX4, PKLR, NR5A2, FOXA3, NEUROG3, HNF1A, HNF1B, FOXA3, NEUROG3 |
| Measles | AKT3, CDK6, CDKN1B, ADAR, IRF9, RACK1, CSNK2A1, EIF2S1, AKT2, FCGR2B, TAB2, FOS, RCHY1, EIF2AK1, BBC3, TBK1, CD209, HSPA1A, HSPA6, HSPA8, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, IL2RB, IL2RG, IRAK1, IRF3, IRF7, JAK1, JAK3, MSN, MX1, MYD88, NFKBIA, NFKBIB, OAS1, OAS2, IRAK4, RAB9B, TLR7, PIK3CD, PIK3R1, PIK3R2, TLR9, MAPK9, MAPK10, EIF2AK2, MAVS, CCND1, RELA, BCL2L1, BID, IFIH1, SLAMF1, STAT2, STAT5A, STAT5B, MAP3K7, TP53, TRAF3, TRAF6, PIK3R3, IKBKG, EIF3H, CBLB, TRADD, FADD, CCND3, CCNE1, CCNE2, CD3E, CD3G, RAB9A, CD28, EIF2AK3, IKBKE, CDK2, CSNK2A2, CSNK2B, AKT1, GSK3B, APAF1, HSPA1A, HSPA1B, HSPA1L, HSPA2, IFNA1, IFNAR2, FAS, IL1A, IL1B, IL2, IL2RA, FASLG, IL6, IL12A, JUN, CD46, NFKB1, PIK3CA, PIK3CB, CYCS, MAPK8, BAD, BAK1, BAX, BCL2, STAT1, STAT3, TLR2, TLR4, TNFAIP3, TP53, TP73, TYK2, CASP3, CASP8, CASP9, CCND2, PIK3CB, TNFAIP3, CCND2 |
| Melanogenesis | CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CREBBP, CALML6, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, ADCY4, EP300, FZD2, GNAI2, GNAI3, GNAQ, HRAS, KRAS, MC1R, MITF, ASIP, LEF1, WNT16, CALML5, PLCB2, PLCB3, WNT4, POMC, PRKACB, PRKACG, PRKCB, PRKCG, MAP2K1, MAP2K2, CREB3L2, TCF7, TYR, TYRP1, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, CALM2, CALM3, CALML3, WNT5B, CAMK2A, CAMK2B, CAMK2D, CAMK2G, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, CREB3L3, WNT3A, CALML4, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CTNNB1, PLCB1, GNAI1, GNAO1, GNAS, GSK3B, KIT, KITLG, PRKACA, PRKCA, MAPK1, MAPK3, RAF1, TCF7L2, WNT5A, CALM1, ADCY1, ADCY3, CREB1, CREB3L4, PRKACA, PRKCA, CALM1 |
| Melanoma | AKT3, CDK6, CDKN1A, DDB2, GADD45A, E2F2, E2F3, AKT2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGF20, FGF21, FGF22, HRAS, KRAS, MITF, GADD45B, POLK, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CD, PIK3R1, PIK3R2, PDGFC, MAP2K1, MAP2K2, CCND1, BRAF, TP53, PDGFD, FGF23, PIK3R3, FGF18, FGF19, CDKN2A, GADD45G, E2F1, EGF, EGFR, AKT1, FGF3, FGF4, FGF8, FGF9, FGFR1, HGF, IGF1, IGF1R, MDM2, MET, PIK3CA, PIK3CB, MAPK1, MAPK3, BAD, PTEN, BAK1, BAX, RAF1, RB1, TP53, FGF17, CDH1, GADD45G, FGF4, PIK3CB |
| Metabolic pathways | ADA, GNPDA1, GNE, PIGK, NT5C1B-RDH14, NDUFC2-KCTD14, COX17, NAMPT, AASS, DHRS9, ALG3, NME6, AK6, COQ7, GPHN, GLYAT, TCIRG1, B3GALT5, AKR1A1, RXYLT1, B3GNT3, CDO1, CEPT1, CDS1, PEMT, ST3GAL6, CDIPT, ACAA2, ATP5PD, AGPAT1, AGPAT2, SPTLC1, POMT1, MTHFS, PAICS, ATP5MG, PMVK, EBP, FUT9, CERS1, UGT2B11, PTGES3, AHCYL1, MTHFD2, FTCD, PDE10A, HPSE, ME3, MAN1A2, EHMT2, UGT2A1, ACOT2, UQCR11, SDS, SLC27A5, LIAS, B4GAT1, AKR1C4, ADCY5, PRDM7, PLAAT3, NUDT5, TREH, INMT, ADCY6, GALNT5, SAT2, HOGA1, MGAT4B, CYP4F8, ADCY7, MGAT4A, MGLL, AZIN2, SDSL, ADCY8, GALNT13, ADCY9, NT5C3B, CKB, CKMT2, ACSM1, GALNT15, GSTO2, LARGE2, CYP2R1, TPH2, AK7, PLD4, ADSS1, ACOT4, DEGS2, HYKK, ACSM2A, ADH1A, EARS2, CANT1, ADH1B, AFMID, COX6B2, ACER1, NDUFA11, B3GALT6, ADH4, ATP6V1G3, PRXL2B, A3GALT2, ADH5, PIGU, MBOAT2, NEU4, ADH6, SGPP2, GALM, UROC1, NUDT16, ADK, GLYCTK, COX4I1, GNPDA2, COX5B, NADK2, COX6A1, COX6A2, COX6B1, CMBL, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, B3GAT2, COX11, CPS1, HGSNAT, CARNMT1, DGKK, UPRT, NANP, CS, AMDHD1, ALG |
| Metabolism of xenobiotics by cytochrome P450 | UGT2B11, UGT2A1, GSTO2, ADH1A, ADH1B, ADH4, ADH5, ADH6, CYP2A6, CYP2C9, CYP2D7, CYP2D6, CYP2E1, CYP3A5, AKR1C1, EPHX1, ALDH1A3, ALDH3B1, ALDH3B2, DHDH, HPGDS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, CYP2S1, HSD11B1, HSD11B1L, MGST2, MGST3, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, AKR7A2, CBR1, CBR3, GSTO1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PIK3CA, PIK3CB, RAF1, RAP1A, SRC, RAB3A, GSTM3 |
| MicroRNAs in cancer | HDAC5, BCL2L11, MIR103B1, MIR103B2, COMMD3-BMI1, MIR203B, CDK6, SPRY2, CDKN1A, CDKN1B, APC2, PAK4, IGF2BP1, CDCA5, TRIM71, CREBBP, CRK, CRKL, E2F2, E2F3, EFNA1, EFNA2, EFNA3, EFNA5, EP300, ERBB3, ZFPM2, ABL1, FOXP1, GLS2, PDCD4, GLS, GRB2, HDAC2, HNRNPK, HOXD10, APC, HRAS, TNC, IKBKB, IRS1, ITGB3, KRAS, STMN1, SHC4, MIRLET7A2, MIRLET7A3, MIRLET7C, MIRLET7D, MIRLET7F1, MIRLET7F2, MIRLET7G, MIR100, MIR103A1, MIR103A2, MIR107, MIR10A, MIR10B, MIR1-1, MIR1-2, MIR124-2, MIR125A, MIR125B1, MIR126, MIR133A2, MIR143, MIR150, MIR15B, MIR16-1, MIR17, MIR183, MIR192, MIR194-2, MIR199A1, MIR199B, MIR19A, MIR19B1, MIR20A, MIR200A, MIR200B, MIR200C, MIR203A, MIR205, MIR206, MIR210, MIR214, MIR222, MIR223, MIR224, MIR23A, MIR23B, MIR25, MIR26A1, MIR26A2, MIR26B, MIR27A, MIR28, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR30B, MIR30C1, MIR30D, MIR30E, MIR31, MIR32, MIR7-1, MIR9-1, MIR96, MIR99A, MARCKS, MDM4, MMP16, MIR324, MIR326, MIR330, MIR331, MIR335, MIR373, NOTCH1, NOTCH3, NOTCH4, MIR375, PDGFA, PDGFB, PDGFRA, PDGFRB, SERPINB5 |
| Mineral absorption | SLC26A9, SLC31A1, TRPM6, SLC34A3, SLC26A3, FTH1, FTL, STEAP2, STEAP1, SLC40A1, HMOX2, SLC6A19, MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1M, MT1X, MT2A, ATOX1, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2B1, ATP2B2, ATP2B3, ATP7A, TRPV6, SLC39A4, MT1HL1, SLC26A6, SLC5A1, SLC8A2, SLC8A1, SLC8A3, SLC34A1, SLC30A1, S100G, CYBRD1, HEPH, CLCN2, HMOX1, SLC11A2, SLC9A3, TF, VDR, SLC11A2, ATP2B4, SLC9A3 |
| Mismatch repair | MSH6, LIG1, POLD1, POLD2, POLD4, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, SSBP1, EXO1, SRC, KIT, MET, MYC, PIK3CA, PIK3CB, POLD3 |
| Mitophagy - animal | OPTN, CALCOCO2, CITED2, GABARAP, GABARAPL2, FUNDC1, CSNK2A1, PGAM5, RRAS2, MRAS, FOXO3, GABARAPL1, ATG9B, TBK1, HRAS, KRAS, NBR1, MITF, ATF4, PRKN, FIS1, TOMM7, RHOT1, AMBRA1, MFN1, MAPK9, MAPK10, RELA, BCL2L1, RPS27A, RRAS, TBC1D15, PINK1, BNIP3, BNIP3L, TFE3, TP53, UBA52, UBB, UBC, RAB7A, ATG9A, TFEB, TBC1D17, ULK1, USP30, BECN1, SQSTM1, TAX1BP1, RHOT2, EIF2AK3, ATG5, MFN2, USP15, CSNK2A2, CSNK2B, E2F1, HIF1A, JUN, MAPK8, SP1, SRC, TP53, USP8 |
| Morphine addiction | GNB5, PDE10A, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, SLC32A1, GRK2, GRK3, DRD1, ADCY4, GABRR3, GABBR1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GABRG1, GABRG2, GABRG3, GABRP, GABRR2, PDE7B, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRK4, GRK5, GRK6, KCNJ9, ARRB2, PDE11A, PDE1A, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE8A, PDE1B, GNG13, GNG2, PRKACB, PRKACG, PRKCB, PRKCG, GABRQ, GNG12, GNB4, CACNA1A, CACNA1B, PDE8B, GNG8, ADCY1, ADCY2, ADCY3, GNAI1, GNAO1, GNAS, KCNJ5, KCNJ6, PRKACA, PRKCA, GABBR2, ADCY1, ADCY3, KCNJ5, KCNJ6, PDE4A, PRKACA, PRKCA, GABBR2 |
| mRNA surveillance pathway | BCL2L2-PABPN1, ALYREF, SRRM1, SAP18, NXF1, HBS1L, CPSF4, PAPOLA, CLP1, NUDT21, CPSF6, PABPC5, CSTF1, CSTF2, CSTF3, ETF1, CASC3, NCBP2, ACIN1, SMG1, SMG6, SMG5, GSPT2, UPF2, SSU72, NXT1, GSPT1, CPSF1, MSI1, NCBP1, PCF11, CPSF3, PELO, CPSF2, PNN, PPP1CB, MAGOHB, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, WDR33, PPP2R2D, NXT2, PAPOLB, UPF1, PAPOLG, UPF3B, UPF3A, DDX39B, CPSF7, WDR82, PABPN1, SYMPK, PYM1, RNMT, RNGTT, PABPC4, EIF4A3, SMG7, RBM8A, RAF1, MAS1, HSD3B1, HSD3B2, LIPE, HSD3B1, HSD3B2, RAF1, MUC5B, MSI2, CSTF2T, DAZAP1, PPP1CC, PPP2R3C, PPP2CB |
| mTOR signaling pathway | AKT3, RRAGB, LAMTOR5, NPRL2, RRAGA, ATP6V1G3, SLC38A9, DVL1, DVL2, DVL3, EIF4B, EIF4E, EIF4EBP1, FLCN, AKT2, RNF152, LPIN1, ATP6V1C2, FZD2, GRB2, GRB10, LAMTOR2, HRAS, IKBKB, INS, IRS1, KRAS, LRP6, LRP5, TBC1D7, ATP6V1D, WNT16, ATP6V1H, PDPK1, CAB39, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1E1, PIK3CD, PIK3R1, PIK3R2, ATP6V1G2, WNT4, MIOS, LAMTOR1, STRADB, PRR5, PRKAA2, PRKCB, PRKCG, MAP2K1, MAP2K2, RPTOR, FNIP2, RRAGD, RHEB, RPS6, RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, CLIP1, SEC13, MLST8, SGK1, DEPTOR, LPIN3, SKP2, SLC3A2, SOS2, BRAF, TNF, TSC1, TSC2, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, MAPKAP1, WDR59, FZD3, WNT10A, WNT5B, NPRL3, CAB39L, SEH1L, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, SESN2, ULK1, WDR24, AKT1S1, PIK3R3, LAMTOR3, WNT3A, ATP6V1E2, STRADA, ATP6V1F, EIF4E2, ATP6V1G1, FNIP1, LPIN2, TTI1, DEPDC5, ULK2, AKT1, MTOR, RICTOR, GSK3B, IGF1, IGF1R, INSR, RHOA, PIK3CA, PIK3CB, PRKAA1, PRKCA, MAPK1, MAPK3, PTEN, RAF1, SOS1, STK11, TNF, TNFRSF1A, WNT5A, SLC7A5, RICTOR, RH |
| Mucin type O-glycan biosynthesis | GALNT5, GALNT13, GALNT15, B3GNT6, GALNT1, GALNT2, GALNT8, GCNT1, C1GALT1C1, GALNT18, GALNTL6, GALNT9, GALNT7, GALNT10, ST6GALNAC1, C1GALT1, GALNT16, GALNT11, GALNT17, ST3GAL1, ST3GAL2, GALNT12, GALNT4, B4GALT5, RAF1, KIR2DS2, GALNT3 |
| N-Glycan biosynthesis | ALG3, MAN1A2, MGAT4B, MGAT4A, ALG10B, MGAT5B, MGAT4D, DAD1, DDOST, DPAGT1, ALG14, STT3B, DOLK, FUT8, MGAT4C, B4GALT1, ALG5, STT3A, MAN1A1, MAN2A2, MAN2A1, MGAT2, MGAT3, ALG1, MAN1C1, RPN1, RPN2, ST6GAL1, ALG8, SRD5A3, ALG13, ST6GAL2, ALG10, ALG2, B4GALT3, B4GALT2, DPM1, DPM2, HLA-A, HLA-B, HLA-C, MGAT1, TUSC3 |
| Natural killer cell mediated cytotoxicity | VAV3, SH2D1B, RAET1E, PTK2B, FCER1G, FCGR3B, SHC2, NCR3, LAT, GRB2, GZMB, HRAS, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DS4, KIR3DL2, KLRC1, KLRC2, KLRC3, KRAS, LCK, LCP2, SHC4, MICB, NFATC1, NFATC2, CD244, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB, PRKCG, MAP2K1, MAP2K2, PTPN6, RAC1, RAC2, RAC3, BID, SH3BP2, SHC1, SOS2, BRAF, SYK, TNF, TYROBP, VAV1, VAV2, ZAP70, ULBP3, ULBP2, ULBP1, PIK3R3, TNFRSF10B, TNFRSF10A, CD247, NCR1, CD48, KIR2DS2, FCGR3A, FYN, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, ICAM1, ICAM2, IFNA1, IFNAR2, IFNG, FAS, FASLG, KIR2DL2, PAK1, PIK3CA, PIK3CB, PLCG1, PRF1, PRKCA, MAPK1, MAPK3, PTPN11, RAF1, SOS1, TNF, CASP3, TNFSF10, ICAM2, PIK3CB, PLCG1, PRKCA |
| Necroptosis | RNF103-CHMP3, IRF9, RBCK1, RIPK3, FAF1, NLRP3, SPATA2L, CHMP4B, TICAM1, CYBB, CYLD, PGAM5, H2AC1, FTH1, FTL, CHMP2B, USP21, CHMP2A, GLUD1, GLUD2, GLUL, CHMP4A, SLC25A4, PYCARD, SLC25A5, SLC25A6, H2AC8, H2AC7, H2AZ1, HMGB1, H2AC21, BIRC2, XIAP, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, JAK1, JAK2, JAK3, H2AB2, H2AB1, CHMP1A, CHMP5, CHMP3, PLA2G4A, PPIA, PPID, RNF31, MACROH2A2, H2AJ, MAPK9, MAPK10, EIF2AK2, CHMP1B, PYGB, PYGL, PYGM, BID, SMPD1, STAT2, STAT5A, STAT5B, STAT6, TLR3, TNF, TRAF2, TRAF5, H2AC19, VDAC2, CHMP6, ZBP1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, SHARPIN, CAPN1, CAPN2, H2AC13, H2AC15, H2AC16, H2AC6, H2AC4, H2AC17, H2AC18, H2AC20, SLC25A31, H2AB3, H2AC12, PLA2G4C, TRADD, FADD, TNFRSF10B, TNFRSF10A, CFLAR, SQSTM1, AIFM1, CHMP7, CHMP4C, H2AZ2, VPS4B, MACROH2A1, PARP2, DNM1L, PARP1, TICAM1, ALOX15, H2AFX, HSP90AA1, HSP90AB1, IFNA1, IFNAR2, IFNG, FAS, IL1A, IL1B, FASLG, MAPK8, BAX, BCL2, STAT1, STAT3, STAT4, TLR4, TNF, TNFAIP3, TNFRSF1A, TYK2, VDAC1, VDAC2, VDAC3, CASP1, CASP8, TNFSF10, IL33, |
| Neomycin, kanamycin and gentamicin biosynthesis | GCK, HK2, HK3, HKDC1, RAP1A, HK1 |
| Neuroactive ligand-receptor interaction | LPAR6, CALCRL, NMUR1, CYSLTR1, NMU, NPFFR2, GPR83, UTS2, HRH3, CHRM1, CHRM2, PTH2, CHRM3, CHRM4, CHRM5, CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB1, CHRNB2, UCN3, CHRNB4, CHRND, CHRNE, CHRNG, GRIN3A, GRIN3B, ADCYAP1R1, LTB4R, CNR1, CORT, ADORA2A, ADORA2B, CRH, CRHR1, CRHR2, ADORA3, CSH1, CSH2, ADRA1D, ADRA1B, ADRA1A, ADRA2A, ADRA2B, CTSG, ADRA2C, ADRB1, ADRB2, ADRB3, GPR156, DRD1, DRD2, DRD3, DRD4, AGT, AGTR1, APLNR, S1PR1, LPAR1, S1PR3, EDN1, EDN3, EDNRB, GABRR3, F2, F2RL2, P2RX2, LPAR3, FPR2, FPR3, NTSR2, GABBR1, TAC4, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GABRG1, GABRG2, GABRG3, GABRP, NPB, GABRR2, GALR1, GCGR, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLRA1, GLRA2, GNRHR, NPBWR1, NPBWR2, PRLHR, UTS2R, LPAR4, MCHR1, GPR35, GRIA1, GRIA2, GRIA3, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRP, GZMA, HCRT, HCRTR1, TAAR6, HRH1, HRH2, HTR1B, HTR1E, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IA |
| Neurotrophin signaling pathway | AKT3, SH2B3, SH2B2, ZNF274, FRS2, PRDM4, IRAK3, CRK, CRKL, CALML6, AKT2, FOXO3, ABL1, GAB1, SHC2, BEX3, GRB2, RAPGEF1, HRAS, IKBKB, IRAK1, IRAK2, IRS1, KRAS, ARHGDIB, ARHGDIG, SHC4, MATK, MAP3K1, MAP3K3, MAP3K5, ATF4, NFKBIA, NFKBIB, NFKBIE, NGFR, NTF3, NTF4, NTRK2, IRAK4, PDPK1, CALML5, PIK3CD, PIK3R1, PIK3R2, SHC3, PLCG2, PRKCD, MAPK7, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K5, MAP2K7, PSEN1, PSEN2, KIDINS220, RAC1, RAP1B, RELA, RPS6KA1, RPS6KA2, SORT1, MAPK12, SHC1, SOS2, BRAF, TP53, TRAF6, YWHAE, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, PIK3R3, RIPK2, CALML4, RPS6KA5, MAGED1, MAPK14, AKT1, SH2B1, GSK3B, FASLG, JUN, RHOA, ARHGDIA, NFKB1, NGF, NTRK1, NTRK3, PIK3CA, PIK3CB, PLCG1, MAPK1, MAPK3, MAPK8, BAD, PTPN11, BAX, RAF1, RAP1A, BCL2, BDNF, SOS1, TP53, TP73, CALM1, CAMK4, MAPKAPK2, CDC42, RHOA, NTRK3, PIK3CB, PLCG1, CALM1, MAPKAPK2 |
| NF-kappa B signaling pathway | TAB1, TNFSF13B, EDAR, TIRAP, TNFRSF13C, EDARADD, CSNK2A1, TICAM1, CYLD, GADD45A, EDA, ERC1, TAB2, LY96, TAB3, LAT, CXCL1, CXCL2, CXCL3, CARD10, BIRC2, XIAP, IKBKB, IL1R1, IRAK1, LBP, LCK, LTA, LTB, LTBR, LYN, MYD88, GADD45B, NFKB2, NFKBIA, IRAK4, PIAS4, PLCG2, PIDD1, PRKCB, PRKCQ, BCL2A1, RELA, RELB, BCL2L1, EDA2R, CCL19, CCL21, CXCL12, SYK, MAP3K7, BTK, TNF, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, UBE2I, VCAM1, ZAP70, TRIM25, CARD14, CARD11, IKBKG, TRADD, TNFSF14, TNFRSF11A, CFLAR, BCL10, MAP3K14, CD40, ERCC1, PIK3CA, PIK3CB, CYCS, BAX, XPA, JUN, PIK3CA, PIK3CB, BAX, RAF1, SRC, PTGS2, BCL2, TLR4, TNF, TNFAIP3, TNFRSF1A, TICAM1, PLCG1, TNFAIP3 |
| Nicotinate and nicotinamide metabolism | NT5C1B-RDH14, NAMPT, NT5C3B, NADK2, SIRT2, NT5C2, NMNAT2, SIRT5, SIRT4, QPRT, NNT, NMRK2, NT5C, AOX1, NMNAT3, NNMT, PNP, NT5E, SIRT7, SIRT6, ENPP1, ENPP3, NMRK1, NADSYN1, ASPDH, NT5M, NMNAT1, NADK, BST1, NUDT12, NT5C1A, NT5C1B, NAPRT, CD38, HLA-DPB1, HLA-DQA1 |
| Nicotine addiction | CHRNA4, CHRNA7, CHRNB2, GRIN3A, GRIN3B, SLC32A1, GABRR3, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GABRG1, GABRG2, GABRG3, GABRP, GABRR2, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GABRQ, SLC17A7, SLC17A6, CACNA1A, CACNA1B, CHRNA6 |
| Nitrogen metabolism | CPS1, CA14, GLUD1, GLUD2, GLUL, CA13, CA1, CA3, CA4, CA5A, CA7, CA8, CA9, CA12, PIK3CB |
| NOD-like receptor signaling pathway | TANK, NAMPT, IRF9, NOD1, TAB1, RBCK1, TXNIP, SUGT1, RIPK3, GABARAP, GABARAPL2, NLRP3, CARD16, GBP5, ANTXR2, NEK7, TICAM1, CTSB, CYBA, CYBB, DEFA1, DEFA3, DEFA4, DEFA5, DEFB4A, NLRP7, NLRP1, CARD8, TAB2, GABARAPL1, PANX1, TAB3, TXN2, PYDC1, GBP1, GBP2, GBP3, PYCARD, TBK1, CXCL1, CXCL2, CXCL3, BIRC2, XIAP, STING1, IFI16, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, IRF3, IRF7, ITPR1, ITPR2, ITPR3, JAK1, MYD88, NAIP, NFKBIA, NFKBIB, OAS1, OAS2, P2RX7, IRAK4, TRPV2, PLCB2, PLCB3, ATG16L1, RNF31, MFN1, PRKCD, PKN1, PKN2, DEFB103B, ERBIN, MAPK11, MAPK9, MAPK10, MAPK13, DHX33, MAVS, CARD18, RELA, BCL2L1, RNASEL, MAPK12, CCL2, NOD2, CARD9, STAT2, MAP3K7, TNF, TP53BP1, TRAF2, TRAF3, TRAF5, TRAF6, TRIP6, TRPM2, VDAC2, YWHAE, NLRX1, GSDMD, SHARPIN, CAMP, ANTXR1, CARD6, IKBKG, RIPK2, FADD, PSTPIP1, ATG12, NLRP12, AIM2, ATG5, IKBKE, MFN2, DNM1L, MAPK14, TICAM1, GPRC6A, PLCB1, HSP90AA1, HSP90AB1, IFNA1, IFNAR2, IL1B, IL6, CXCL8, IL18, JUN, RHOA, MEFV, NFKB1, MAPK1, MAPK3, MAPK8, BCL2, CCL5, STAT1, TLR4, TNF, TNFAIP3, TXN, |
| Non-alcoholic fatty liver disease | AKT3, BCL2L11, NDUFC2-KCTD14, UQCR11, COX6B2, NDUFA11, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, CYC1, CYP2E1, DDIT3, COX7B2, EIF2S1, AKT2, ERN1, MLXIP, UQCRQ, UQCR10, COX8C, IKBKB, INS, IRS1, NDUFS7, MAP3K5, UQCRHL, COX2, ATF4, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ADIPOR1, PRKAG2, PIK3CD, PIK3R1, PIK3R2, PKLR, NDUFB11, PPARA, PRKAA2, PRKAB1, NDUFA12, MAPK9, MAPK10, NDUFA4L2, RAC1, RELA, BID, SDHC, SDHD, SREBF1, MLX, TNF, TRAF2, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, XBP1, ADIPOR2, ITCH, CASP7, PIK3R3, IRS2, SOCS3, COX7A2L, ADIPOQ, COX5A, EIF2AK3, NR1H3, AKT1, GSK3A, GSK3B, FAS, IL1A, IL1B, FASLG, IL6, IL6R, CXCL8, INSR, JUN, LEP, LEPR, MAP3K11, COX1, COX3, CYTB, NDUFS3, NFKB1, NDUFA13, PIK3CA, PIK3CB, CYCS, PRKAA1, MAPK8, BAX, RXRA, SDHA, SDHB, TGFB1, TNF, TNFRSF1A, |
| Non-homologous end-joining | RAD50, DNTT, FEN1, XRCC6, POLL, MRE11, PRKDC, DCLRE1C, XRCC4, XRCC5, NHEJ1, RAF1 |
| Non-small cell lung cancer | AKT3, CDK6, CDKN1A, DDB2, GADD45A, E2F2, E2F3, AKT2, FHIT, FOXO3, ALK, EML4, GRB2, HRAS, JAK3, KRAS, GADD45B, POLK, PDPK1, PIK3CD, PIK3R1, PIK3R2, PLCG2, PRKCB, PRKCG, MAP2K1, MAP2K2, RARB, CCND1, RXRG, SOS2, BRAF, STAT5A, STAT5B, STK4, TGFA, TP53, RASSF5, PIK3R3, CDKN2A, GADD45G, RASSF1, E2F1, EGF, EGFR, ERBB2, AKT1, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, BAD, BAK1, BAX, RAF1, RB1, RXRA, RXRB, SOS1, STAT3, TP53, CASP9, GADD45G, PIK3CB, PLCG1, PRKCA, RXRA, RXRB, TGFA |
| Notch signaling pathway | DLL3, DTX2, CREBBP, CTBP1, CTBP2, DTX3L, JAG1, DTX1, DVL1, DVL2, DVL3, DTX3, EP300, SNW1, DTX4, HEY1, HEY2, KAT2A, DLL1, HDAC2, HES1, ATXN1L, RBPJ, JAG2, LFNG, MFNG, NOTCH1, NOTCH3, NOTCH4, APH1A, MAML3, PSENEN, PSEN1, PSEN2, ATXN1, APH1B, MAML2, NUMB, KAT2B, NUMBL, CIR1, NCOR2, MAML1, MET, PIK3CA |
| Nucleotide excision repair | CDK7, CETN2, ERCC8, DDB1, DDB2, ERCC4, ERCC5, ERCC6, GTF2H1, GTF2H3, GTF2H4, LIG1, GTF2H5, MNAT1, POLE3, POLD1, POLD2, POLE, POLE4, POLD4, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, CCNH, RBX1, H2BFWT, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, JUN, PIK3CA, PIK3CB, BAX, POLD3, CUL4B, CUL4A |
| Olfactory transduction | OR5I1, OR51A7, OR5P2, OR5P3, OR56A4, OR10AD1, SLC24A4, CNGB1, CNGA2, OR2T4, OR9A4, OR2A14, OR13C8, OR13C4, OR1N2, OR10A5, OR6B3, GRK2, GRK3, CALML6, OR5T2, OR5R1, OR5AR1, OR9Q1, OR9Q2, OR10Q1, OR5B21, OR4D11, OR52A1, OR2T6, OR52B2, OR51F1, OR1C1, OR2M4, OR5K1, OR10J1, OR8G1, OR10A3, OR12D2, OR10H2, OR10H1, OR7C2, OR7C1, OR2W1, OR2T1, OR2J2, OR2H1, GNAL, GNB1, GNG7, OR51B5, OR4C12, OR51V1, OR8D2, OR10A4, OR2Z1, OR2L13, GUCY2D, OR8D4, OR5F1, OR2AG2, OR51B6, OR51I2, OR52D1, OR52E4, OR4X1, OR4K17, OR2T33, OR1L6, OR5C1, OR6C68, ARRB2, OR1F1, OR3A1, OR8U8, PDE1A, PDE1C, PDE2A, PDE1B, GNG13, CALML5, PRKACB, PRKACG, PRKG1, OR2S2, ANO2, RGS2, SLC8A2, SLC8A1, SLC8A3, OR13A1, OR2A4, CALM2, CALM3, CALML3, OR5AC2, CAMK2A, CAMK2B, OR5V1, CAMK2D, CAMK2G, OR1D5, OR1E1, OR1G1, NCALD, CALML4, ADCY3, OR2W3, PRKACA, CALM1, ADCY3, PRKACA, CALM1 |
| One carbon pool by folate | MTHFS, MTHFD2, ALDH1L1, FTCD, MTFMT, ALDH1L2, DHFR, DHFR2, MTHFD1L, GART, AMT, MTHFD2L, ATIC, SHMT1, SHMT2, TYMS, HLA-DRB1, JUN, JUN |
| Oocyte meiosis | MAD2L2, PTTG2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CPEB2, SGO1, CALML6, ADCY4, CPEB3, FBXW11, SPDYA, CDC26, ANAPC13, FBXO5, SPDYE1, FBXO43, ANAPC2, ANAPC4, INS, ITPR1, ITPR2, ITPR3, SPDYE4, MAD2L1, MOS, SPDYE3, SPDYE5, ANAPC5, ANAPC7, ANAPC11, CALML5, PLK1, PPP1CB, PPP2CA, PPP2R1A, PPP2R1B, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, MAPK11, MAPK13, MAP2K1, RPS6KA1, RPS6KA2, MAPK12, CPEB1, ANAPC1, SKP1, BUB1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, CPEB4, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, SMC1A, MAD1L1, CUL1, CDC23, CDC16, BTRC, CCNE1, PKMYT1, SMC3, CCNE2, CALML4, ESPL1, SLK, CDC27, RBX1, CDK2, ADCY1, STAG3, ADCY2, ADCY3, YWHAQ, MAPK14, SMC1B, IGF1, IGF1R, AR, PGR, PPP1CC, PPP2CB, PRKACA, MAPK1, MAPK3, AURKA, CALM1, CCNB1, PLCZ1, CCNB2, PTTG1, CDK1, CDC20, CDC25C, REC8, ADCY1, ADCY3, SMC1B, PPP1CC, PPP2CB, PRKACA, CALM1 |
| Osteoclast differentiation | AKT3, LILRB2, SIRPB1, IRF9, TAB1, LILRB5, LILRB4, LILRA1, LILRB3, LILRA3, LILRA2, OSCAR, CSF1R, CTSK, CYBA, CYLD, AKT2, FCGR2A, FCGR2B, FCGR3B, FHL2, TAB2, FOS, FOSB, LILRA4, FOSL2, NOX1, GRB2, IFNAR1, IFNGR1, IFNGR2, LILRA5, IKBKB, IL1R1, ITGB3, JAK1, JUNB, JUND, LCK, LCP2, MITF, NCF4, NFATC1, NFATC2, NFKB2, NFKBIA, TNFRSF11B, PIK3CD, PIK3R1, PIK3R2, PLCG2, TREM2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K6, MAP2K7, RAC1, RELA, RELB, MAPK12, NCF1, SPI1, STAT2, SYK, MAP3K7, BTK, TEC, TGFB2, TGFBR1, TGFBR2, TNF, TRAF2, TRAF6, TYROBP, LILRA6, CALCR, PIK3R3, IKBKG, SOCS1, TNFRSF11A, SQSTM1, MAP3K14, SOCS3, FCGR2C, GAB2, CREB1, SIRPA, MAPK14, CSF1, AKT1, FCGR3A, FYN, IFNAR2, IFNG, IL1A, IL1B, JUN, NFKB1, PIK3CA, PIK3CB, PPARG, SIRPG, MAPK1, MAPK3, MAPK8, STAT1, TGFB1, TNF, TNFRSF1A, TYK2, CAMK4, CREB1, PIK3CB |
| Other glycan degradation | NEU4, AGA, MAN2B2, FUCA1, FUCA2, HEXD, MAN2C1, MANBA, NEU1, NEU2, GBA2, JUN, PIK3CA, PIK3CB, RAF1, HLA-DPB1, HLA-DQA1 |
| Other types of O-glycan biosynthesis | POMT1, GALNT5, GALNT13, GALNT15, B3GLCT, XXYLT1, COLGALT2, POFUT2, POFUT1, GALNT1, GALNT2, GALNT8, B4GALT1, GXYLT1, EOGT, C1GALT1C1, GALNT18, LFNG, MFNG, GALNTL6, GALNT9, GALNT7, GALNT10, C1GALT1, POGLUT1, GALNT16, GALNT11, GALNT17, ST6GAL1, GALNT12, COLGALT1, ST6GAL2, OGT, GALNT4, B4GALT3, B4GALT2, PLOD3, GALNT3 |
| Ovarian steroidogenesis | ACOT2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ACOT4, CYP2J2, ADCY4, ALOX5, INS, LDLR, HSD17B7, PLA2G4A, PRKACB, PRKACG, BMP6, STAR, PLA2G4C, SCARB1, ADCY1, ADCY2, CGA, ADCY3, CYP1A1, CYP1B1, CYP11A1, CYP17A1, CYP19A1, FSHB, FSHR, GNAS, HSD3B1, HSD3B2, HSD17B1, HSD17B2, IGF1, IGF1R, INSR, LHB, LHCGR, PRKACA, PTGS2, AKR1C3, BMP15, ADCY1, ADCY3, PRKACA |
| Oxidative phosphorylation | NDUFC2-KCTD14, COX17, TCIRG1, ATP5PD, ATP5MG, UQCR11, COX6B2, NDUFA11, ATP6V1G3, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, COX11, CYC1, ATP6V0E2, COX7B2, ATP6V1C2, PPA2, UQCRQ, UQCR10, COX8C, NDUFS7, UQCRHL, COX2, ND1, ND4L, ND5, ND6, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ATP4A, ATP4B, ATP5F1B, ATP6V0A4, ATP5F1C, ATP5F1D, ATP6V1D, ATP5F1E, ATP5PB, ATP5MC1, ATP6V1H, ATP5MC2, ATP5MC3, ATP5ME, ATP5PF, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V0B, ATP6V1G2, ATP6V0A1, ATP6AP1, ATP5PO, NDUFB11, PPA1, NDUFA12, NDUFA4L2, SDHC, SDHD, LHPP, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, ATP6V0E1, ATP6V1E2, ATP6V0D1, COX7A2L, ATP6V1F, COX5A, ATP6V1G1, ATP5MF, PIK3CA, PIK3CB, PFKFB3, PIK3CA, PIK3CB, PIK3CA, PIK3CB, RAF1, PIK3CA, PIK3CB, FYN, KIT, PIK3CA, NDUFS3, NDUF |
| Oxytocin signaling pathway | CDKN1A, CACNG3, CACNG2, CAMKK2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, MYL6B, PIK3R6, CALML6, RCAN1, EEF2, ADCY4, ELK1, FOS, PIK3R5, CACNG4, GNAI2, GNAI3, GNAQ, GUCY1A2, GUCY1A1, GUCY1B1, EEF2K, HRAS, MYLK4, ITPR1, ITPR2, ITPR3, KCNJ2, KCNJ4, KCNJ9, KCNJ12, KRAS, MEF2C, MYL6, MYLK, PPP1R12A, PPP1R12B, NFATC1, NFATC2, NFATC3, NFATC4, NPR1, NPR2, PRKAG2, CALML5, PIK3CG, PLA2G4A, PLCB2, PLCB3, PPP1R12C, PPP1CB, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKAA2, PRKAB1, PRKACB, PRKACG, PRKCB, CACNA2D3, PRKCG, MAPK7, MAP2K1, MAP2K2, MAP2K5, CAMK1D, CACNG8, CACNG7, CACNG6, CCND1, RGS2, ROCK1, RYR1, RYR2, ACTG1, TRPM2, CACNA1C, CACNA1D, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK1, MYLK2, PLA2G4C, MYLK3, CALML4, CACNA2D2, CACNA2D4, ROCK2, CD38, ADCY1, ADCY2, ADCY3, EGFR, PLCB1, GNAI1, GNAO1, GNAS, JUN, KCNJ5, KCNJ6, RHOA, NOS3, OXT, OXTR, PPP1CC, PRKAA1, PRKACA, PRKCA, MAPK1, MAPK3, PTGS2, RAF1, ACTB, RYR3, SRC, CACNA1S, CACNA2D1, CALM1, CAMK4, ADCY1, ADCY3, KCNJ5, KCN |
| p53 signaling pathway | CDK6, CDKN1A, SIVA1, SESN3, DDB2, GADD45A, RCHY1, BBC3, SFN, MDM4, GADD45B, RRM2B, SHISA5, GTSE1, SERPINB5, STEAP3, PIDD1, ADGRB1, CCND1, BCL2L1, RRM2, BID, TP53AIP1, PERP, COP1, ZMAT3, SIAH1, THBS1, TP53, TSC2, SESN2, TNFRSF10B, CCND3, CCNE1, CCNG1, CCNG2, CCNE2, GORAB, EI24, TP53I3, CDK2, CDKN2A, GADD45G, CHEK1, CHEK2, APAF1, IGF1, IGFBP3, FAS, MDM2, ATM, SERPINE1, CYCS, ATR, PTEN, BAX, BCL2, TP53, TP73, CASP3, CASP8, CASP9, PPM1D, CCNB1, CCND2, CCNB2, CDK1, GADD45G, CHEK1, PPM1D, CCND2 |
| Pancreatic cancer | AKT3, CDK6, CDKN1A, RALBP1, DDB2, GADD45A, E2F2, E2F3, AKT2, IKBKB, JAK1, KRAS, SMAD2, SMAD3, SMAD4, GADD45B, POLK, PIK3CD, PIK3R1, PIK3R2, PLD1, PLD2, MAPK9, MAPK10, MAP2K1, RAC1, RAC2, RAC3, RALA, RALB, RALGDS, CCND1, RELA, BCL2L1, RPS6KB1, RPS6KB2, BRAF, TGFA, TGFB2, TGFBR1, TGFBR2, TP53, PIK3R3, IKBKG, ARHGEF6, CDKN2A, GADD45G, E2F1, EGF, EGFR, ERBB2, AKT1, MTOR, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, BAD, BAK1, BAX, RAD51, RAF1, RB1, BRCA2, STAT1, STAT3, TGFB1, TGFB3, TP53, VEGFA, CASP9, CDC42, GADD45G, PIK3CB, RAD51, TGFA |
| Pancreatic secretion | CELA3A, ADCY5, ADCY6, ADCY7, CHRM3, ADCY8, ADCY9, CPA1, CPA2, CPA3, CTRB1, CTRL, SLC26A3, ADCY4, TPCN2, CELA3B, PLA2G2D, GNAQ, ITPR1, ITPR2, ITPR3, KCNMA1, RAB8A, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, PLA2G3, PLA2G1B, PLA2G5, PLCB2, PLCB3, PNLIP, PNLIPRP1, PNLIPRP2, PRKCB, PRKCG, PRSS3, RAB27B, RAC1, RAP1B, RYR2, CELA2A, SCT, SCTR, SLC4A2, SLC9A1, SLC12A2, BST1, TRPC1, PLA2G12A, PLA2G10, PLA2G12B, SLC4A4, RAB11A, CCK, CCKAR, CD38, RAB3D, ADCY1, ADCY2, CFTR, ADCY3, CLCA4, PLCB1, AMY1A, GNAS, AMY2A, KCNQ1, RHOA, ATP2B4, PLA2G2A, PRKCA, RAP1A, CA2, ADCY1, ADCY3, AMY1A, KCNQ1, RHOA, ATP2B4, PRKCA |
| Pantothenate and CoA biosynthesis | DPYD, DPYS, GADL1, ENPP1, ENPP3, UPB1, PANK1, PANK4, VNN3, BCAT1, BCAT2, PPCDC, PPCS, COASY, VNN2, VNN1, HLA-DQB1 |
| Parathyroid hormone synthesis, secretion and action | CDKN1A, CREB3, ADCY5, ADCY6, AKAP13, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, SLC34A3, CYP27B1, HBEGF, EGR1, ADCY4, FOS, GATA3, GNA11, GNA12, GNAI2, GNAI3, GNAQ, ITPR1, ITPR2, ITPR3, JUND, LRP6, LRP5, ARRB2, MEF2C, MEF2D, MMP13, MMP14, MMP15, MMP16, MMP17, NACA, ATF4, NR4A2, PDE4A, PDE4B, PDE4C, PDE4D, PLCB2, PLCB3, PLD1, PLD2, PRKACB, PRKACG, PRKCB, PRKCG, MAP2K1, PTHLH, PTH1R, RXRG, MMP25, CREB3L2, SLC34A1, BRAF, FGF23, CREB3L3, GCM1, RUNX2, ARHGEF1, GCM2, KL, SLC9A3R1, CREB5, ARHGEF11, GNA13, ADCY1, ADCY2, ADCY3, CREB1, CREB3L4, CYP24A1, EGFR, FGFR1, PLCB1, GNAI1, GNAS, RHOA, MEF2A, PRKACA, PRKCA, MAPK1, MAPK3, RAF1, BCL2, RXRA, RXRB, BGLAP, SP1, VDR, MAFB, GNA13, ADCY1, ADCY3, CREB1, CREB3L4, GNA12, RHOA, PDE4A, PRKACA, PRKCA, RXRA, RXRB, MAFB |
| Parkinson disease | NDUFC2-KCTD14, PPIF, TRAP1, PSMD14, TUBB4A, TUBB4B, ATP5PD, UQCR11, ADRM1, ADCY5, TUBA3E, TUBA3D, UBE2J2, LRRK2, COX6B2, NDUFA11, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, ADORA2A, COX7C, COX8A, PSMA8, KLC3, CYC1, CALML6, DDIT3, COX7B2, DRD1, DRD2, DUSP1, EIF2S1, TUBB, ERN1, TXN2, UQCRQ, HTRA2, GNAI2, GNAI3, GNAL, SLC25A4, SLC25A5, SLC25A6, UQCR10, COX8C, TUBB8, ITPR1, ITPR2, ITPR3, NDUFS7, KIF5A, KIF5B, KLC1, MAP3K5, UQCRHL, COX2, ND1, ND4L, ND5, ND6, ATF4, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ATP5F1B, PRKN, ATP5F1C, ATP5F1D, ATP5F1E, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, CALML5, ATP5PF, ATP5PO, SEPTIN5, NDUFB11, MFN1, PRKACB, PRKACG, NDUFA12, MAPK9, MAPK10, PSMA1, PSMA2, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, NDUFA4L2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC1, PSMC2, PSMC3, PSMC |
| Pathogenic Escherichia coli infection | ABI1, ABCF2, ARPC5, ARPC4, ARPC3, ARPC1B, WASF2, TUBB4A, TUBB4B, SEC24B, TAB1, BAIAP2, ARPC1A, CLDN16, NCKAP1, SEC24A, WASF3, TMED10, TUBA3E, TUBA3D, NLRP3, TIRAP, ARHGEF25, CLDN4, CLDN7, CLDN23, WIPF2, NLRP4, LPAR1, CTTN, TUBB, F2, FCGR2A, TAB2, CYFIP1, ARHGEF12, FOS, CLDN14, CLDN15, ABL1, TAB3, CLDN17, CYFIP2, CYTH4, GNA12, MYO1H, LPAR4, PYCARD, HCK, HCLS1, NCKAP1L, TUBB8, IKBKB, IL1R1, IRAK1, ARF1, ARF6, LYN, MYO1B, MYO1F, MYD88, MYH1, MYH2, MYH3, MYH8, MYH9, MYH10, MYH11, MYO1C, MYO1D, MYO5A, MYO5B, MYO6, MYO10, NAIP, NCK1, NCL, NFKBIA, NFKBIB, PAK3, IRAK4, CLDN18, MYO5C, BAIAP2L1, MAPK11, MAPK9, MAPK10, MAPK13, LPAR5, MYH7B, PTPN6, RAB1A, RAC1, RELA, ROCK1, RPS3, MAPK12, MYO1G, MAP3K7, TMBIM6, TJP1, ACTG1, TLR5, CLDN5, TNF, TRAF2, TRAF6, TUBB2A, WIPF1, MYH14, TUBAL3, ARPC5L, CASP7, NCK2, TUBB6, TUBA1C, IKBKG, TRADD, MYH13, FADD, TNFRSF10B, TNFRSF10A, WASF1, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, ARHGEF1, LPAR2, ARHGEF2, CYTH3, CYTH2, CYTH1, SLC9A3R1, ROCK2, SEC24C, ARHGEF11, SEC24D, ARPC2, TUBB3, GNA |
| Pathways in cancer | AKT3, BCL2L11, RASGRP1, LPAR6, CDK6, RASGRP2, CDKN1A, CDKN1B, APC2, CDKN2B, LAMC3, TFG, TXNRD2, GNB5, DLL3, RALBP1, PIM2, ADCY5, ADCY6, EGLN2, ADCY7, ADCY8, ADCY9, RASGRP4, CKS1B, CKS2, GSTO2, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, CREBBP, CRK, CRKL, CSF1R, CSF2RB, CSF3R, CTBP1, CTBP2, IL23R, CTNNA1, CTNNA2, DAPK1, DCC, CALML6, DDB2, GADD45A, NQO1, JAG1, AGT, AGTR1, DVL1, DVL2, DVL3, E2F2, E2F3, LPAR1, EDN1, EDNRB, ADCY4, ELK1, EP300, EPAS1, EPO, EPOR, AKT2, ESR1, ETS1, MECOM, F2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, FH, FLT3LG, FLT4, ARHGEF12, FRAT2, HEY1, HEY2, FOS, LPAR3, DAPK2, ALK, ABL1, FZD2, RASGRP3, APPL1, FGF20, FGF21, FGF22, BBC3, GLI1, GLI2, GLI3, EML4, GNA11, GNA12, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, LPAR4, DLL1, GRB2, CTNNA3, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, MSH6, HDAC2, APC, HRAS, HES1, BIRC2, XIAP, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IFNGR1, IFNGR2, IKBKB, IL2RB, IL2RG, IL3, IL4R, IL5RA, IL7, IL7R, IL12RB1, IL12RB2, IL13, |
| PD-L1 expression and PD-1 checkpoint pathway in cancer | AKT3, RASGRP1, BATF, TIRAP, BATF2, CSNK2A1, TICAM1, AKT2, FOS, ALK, LAT, EML4, CD274, HRAS, IFNGR1, IFNGR2, IKBKB, JAK1, JAK2, KRAS, LCK, MAP3K3, MYD88, NFATC1, NFATC2, NFATC3, NFKBIA, NFKBIB, NFKBIE, PIK3CD, PIK3R1, PIK3R2, TLR9, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, BATF3, PRKCQ, MAPK11, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, PTPN6, RELA, RPS6KB1, RPS6KB2, MAPK12, TRAF6, ZAP70, PIK3R3, IKBKG, CD3E, CD3G, CD247, CD4, CD28, MAPK14, CSNK2A2, CSNK2B, TICAM1, EGF, EGFR, AKT1, MTOR, HIF1A, IFNG, JUN, NFKB1, PDCD1, PIK3CA, PIK3CB, PLCG1, MAPK1, MAPK3, PTEN, PTPN11, RAF1, STAT1, STAT3, TLR2, TLR4, TICAM1, PIK3CB, PLCG1 |
| Pentose and glucuronate interconversions | AKR1A1, UGT2B11, UGT2A1, AKR1B1, DHDH, GUSB, CRYL1, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, AKR1B10, UGT2A2, RPE, SORD, CRPPA, UGDH, UGP2, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, KL, XYLB, KIT |
| Pentose phosphate pathway | GLYCTK, FBP1, PRPS1L1, ALDOA, ALDOB, RPIA, ALDOC, PGLS, GPI, IDNK, DERA, PFKL, PFKM, PFKP, PGD, PGM1, PGM2, PRPS1, RPE, RBKS, TALDO1, TKT, TKTL1, TKTL2, FBP2, RGN, H6PD, RAF1, RAP1A |
| Peroxisome | ECI2, SLC25A17, PMVK, SLC27A2, PXMP4, CRAT, AGXT, ECH1, PAOX, ABCD1, ACSL1, ACSL3, ACSL4, ABCD2, ACSL6, MLYCD, AMACR, MPV17L, PRDX5, HACL1, DECR2, ACAA1, HMGCL, IDH2, MPV17, MVK, ACOX1, HAO2, PIPOX, PEX5L, ACSL5, PEX1, PEX7, PEX12, PEX13, PEX14, PHYH, HAO1, HMGCLL1, PEX26, FAR2, PECR, BAAT, PEX19, ABCD4, PXMP2, PEX2, PEX5, SCP2, ACOX2, ACOX3, NUDT12, FAR1, GNPAT, MPV17L2, PEX3, DDO, AGPS, PEX11B, PEX11A, PEX11G, PEX16, DAO, EPHX2, HSD17B4, IDH1, GSTK1, NOS2, PRDX1, PEX10, SOD1, SOD2, XDH, CAT |
| Pertussis | NOD1, CFL2, NLRP3, TIRAP, TICAM1, CALML6, FOS, LY96, GNAI2, GNAI3, PYCARD, IRF8, IRAK1, IRF1, IRF3, ITGAM, ITGB2, MYD88, IRAK4, CALML5, MAPK11, MAPK9, MAPK10, MAPK13, RELA, MAPK12, CXCL6, CXCL5, SERPING1, C1QA, TNF, C1QB, C1QC, C1R, C1S, C2, TRAF6, C4BPB, C5, CALM2, CALM3, CALML3, CASP7, CALML4, CFL1, MAPK14, TICAM1, GNAI1, IL1A, IL1B, IL6, CXCL8, IL10, IL12A, ITGA5, ITGB1, JUN, RHOA, NFKB1, NOS2, IL23A, MAPK1, MAPK3, MAPK8, TLR4, TNF, C3, CALM1, CASP1, CASP3, TICAM1, RHOA, CALM1 |
| Phagosome | TCIRG1, TLR6, TUBB4A, TUBB4B, SEC61B, CORO1A, TUBA3E, TUBA3D, ATP6V1G3, COMP, CTSL, CTSS, CYBA, CYBB, ATP6V0E2, DYNC1I1, DYNC1I2, DYNC1LI2, PIKFYVE, TUBB, FCAR, FCGR2A, FCGR2B, FCGR3B, PLA2R1, SEC61G, STX12, ATP6V1C2, SEC61A1, CD209, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, TUBB8, ITGA2, ITGAM, ITGB2, ITGB3, ITGB5, LAMP1, LAMP2, M6PR, MBL2, MPO, MRC1, NCF4, OLR1, ATP6V0A4, DYNC1LI1, ATP6V1D, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, PIK3C3, ATP6V1E1, ATP6V0B, ATP6V1G2, STX18, ATP6V0A1, ATP6AP1, SEC61A2, RAB5A, RAB5B, RAB5C, RAC1, SFTPD, NCF1, TAP1, TAP2, TFRC, THBS1, THBS2, THBS3, THBS4, ACTG1, C1R, TUBB2A, RAB7A, COLEC11, TUBAL3, COLEC12, CALR, CANX, RILP, EEA1, STX7, TUBB6, TUBA1C, MARCO, ATP6V0E1, ATP6V1E2, FCGR2C, ATP6V0D1, HGS, ATP6V1F, VAMP3, CD36, SCARB1, ATP6V1G1, SEC22B, MRC2, TUBB3, DYNC1H1, FCGR3A, ATP6V0A2, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, TUBB2B, ITGA5, ITGAV, ITGB1, TUBA8, ACTB, CLEC7A, TLR2, TLR4, C3, TUBA4A, TUBA3C |
| Phenylalanine metabolism | GLYAT, DDC, ALDH1A3, ALDH3B1, ALDH3B2, GOT1, GOT2, AOC2, HPD, PAH, TAT, AOC3, HLA-DQA1, HLA-DQB1, HLA-DRA, IL4I1 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | GOT1, GOT2, PAH, TAT, PIK3CB, IL4I1 |
| Phosphatidylinositol signaling system | CDS1, CDIPT, IP6K3, DGKK, DGKA, DGKB, DGKG, DGKH, DGKQ, CALML6, PIKFYVE, INPP5F, SACM1L, PPIP5K2, PIP5K1C, IPMK, IMPA1, IMPA2, INPP1, INPP4A, INPP5A, INPP5B, INPP5D, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MTM1, OCRL, PLCE1, IP6K2, INPP5K, CALML5, PIK3C2A, PIK3C2B, PIK3C3, PIK3CD, PIK3R1, PIK3R2, PI4KA, PI4KB, PIP4K2A, PLCB2, PLCB3, PLCD1, PLCG2, BPNT2, PI4K2B, PI4K2A, PIP4P2, MTMR8, PRKCB, PRKCG, INPP5E, MTMR14, IPPK, PIP4K2C, CALM2, CALM3, CALML3, PIP5K1A, PIP5K1B, PIP4K2B, PLCD4, PIK3R3, DGKZ, DGKE, DGKD, MTMR1, INPP4B, SYNJ1, SYNJ2, MTMR3, PIP4P1, MTMR6, MTMR7, MTMR4, DGKI, CALML4, PLCB1, PIK3CA, PIK3CB, PLCG1, PRKCA, PTEN, CALM1, MTMR2, PLCZ1, PPIP5K1, IP6K1, PIK3CB, PLCG1, PRKCA, CALM1, MTMR2, IP6K1 |
| Phospholipase D signaling pathway | AKT3, LPAR6, RAPGEF3, AGPAT1, AGPAT2, RAPGEF4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, DGKK, PIK3R6, DGKA, DGKB, DGKG, DGKH, DGKQ, DNM1, AGT, AGTR1, LPAR1, ADCY4, AKT2, F2, PTK2B, FCER1A, MS4A2, FCER1G, RRAS2, MRAS, PIP5K1C, PIK3R5, LPAR3, GAB1, SHC2, DNM3, CYTH4, GNA12, LPAR4, GRB2, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, HRAS, CXCR1, CXCR2, INS, ARF1, ARF6, KRAS, SHC4, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PLA2G4A, PLCB2, PLCB3, SHC3, PLCG2, PLD1, PLD2, AVP, AVPR1B, AVPR2, PDGFC, MAP2K1, MAP2K2, SPHK2, AGPAT3, AGPAT4, LPAR5, RALA, RALB, RALGDS, RHEB, RRAS, SHC1, SOS2, SYK, TSC1, TSC2, PDGFD, PIP5K1A, PIP5K1B, PIK3R3, DGKZ, DGKE, DGKD, PLA2G4C, PLPP1, PLPP2, PLPP3, DGKI, LPAR2, CYTH3, CYTH2, CYTH1, GAB2, GNA13, ADCY1, ADCY2, ADCY3, DNM2, EGF, EGFR, AKT1, F2R, PLCB1, MTOR, FYN, GNAS, CXCL8, INSR, KIT, RHOA, KITLG, PIK3CA, PIK3CB, PLCG1, PRKCA, MAPK1, MAPK3, PTPN11, RAF1, SOS1, GNA13, ADCY1, ADCY3, GNA12, RHOA, PIK3CB, PLCG1, PRKCA |
| Phosphonate and phosphinate metabolism | CEPT1, PCYT1A, CHPT1, PCYT2, SELENOI, PCYT1B |
| Phototransduction | CNGB1, GRK7, CALML6, GNAT2, GNB1, GNGT1, GUCA1A, GUCY2F, GUCY2D, PDE6A, PDE6G, PDE6B, CALML5, RCVRN, RHO, GRK1, SAG, CALM2, CALM3, CALML3, RGS9, CALML4, SLC24A1, GUCA1C, CALM1, CALM1 |
| PI3K-Akt signaling pathway | AKT3, BCL2L11, C8orf44-SGK3, SGK2, LPAR6, CDK6, CDKN1A, CDKN1B, LAMC3, CREB3, GNB5, CHAD, CDC37, CHRM1, CHRM2, THEM4, PIK3AP1, COL1A2, COL2A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COL9A2, COL9A3, COMP, COL6A6, ATF2, ATF6B, CSF1R, CSF3, CSF3R, CSH1, CSH2, PIK3R6, LPAR1, EFNA1, EFNA2, EFNA3, EFNA5, EPHA2, EIF4B, EIF4E, EIF4EBP1, EPO, EPOR, ERBB3, EREG, AKT2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, ITGA11, PHLPP2, FOXO3, FLT3LG, PHLPP1, FLT4, PIK3R5, LPAR3, SGK3, COL6A5, FGF20, FGF21, GH2, GHR, FGF22, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, ANGPT1, LPAR4, ANGPT2, GRB2, PKN3, GYS1, GYS2, NR4A1, HRAS, TNC, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, IL2RB, IL2RG, IL3, IL4R, IL7, IL7R, INS, IRS1, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JAK1, JAK2, JAK3, AREG, KRAS, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, MTCP1, ATF4, NGFR, NTF3, NTF4, NTRK2, OSM, PCK2, ANGPT4, PDGFA, PDGFB, PDGFRA, PDGFRB, PDPK1, GNG |
| Platelet activation | AKT3, RASGRP1, RASGRP2, MYL12B, MYL12A, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, COL1A2, COL3A1, PIK3R6, ADCY4, AKT2, F2, FCER1G, FCGR2A, FGA, FGB, FGG, ARHGEF12, PIK3R5, GNAI2, GNAI3, GNAQ, GP1BA, GP1BB, GP9, ARHGAP35, GUCY1A2, GUCY1A1, GUCY1B1, MYLK4, ITGA2, ITGA2B, ITGB3, ITPR1, ITPR2, ITPR3, LCP2, LYN, MYLK, PPP1R12A, P2RY1, GP6, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PLA2G4A, PLCB2, PLCB3, PLCG2, PPP1CB, PRKACB, PRKACG, PRKCZ, PRKG1, MAPK11, MAPK13, PTGIR, RAP1B, ROCK1, MAPK12, P2RY12, STIM1, SYK, TBXA2R, TBXAS1, BTK, TLN1, ACTG1, VASP, TLN2, FERMT3, PIK3R3, MYLK2, PLA2G4C, VAMP8, SNAP23, F2RL3, ARHGEF1, MYLK3, ROCK2, GNA13, ADCY1, ADCY2, ADCY3, COL1A1, MAPK14, AKT1, F2R, PLCB1, FYN, GNAI1, GNAS, ITGB1, RHOA, NOS3, P2RX1, PIK3CA, PIK3CB, PPP1CC, PRKACA, MAPK1, MAPK3, PTGS1, RAP1A, ACTB, SRC, VWF, GNA13, ADCY1, ADCY3, RHOA, P2RX1, PIK3CB, PPP1CC, PRKACA |
| Platinum drug resistance | AKT3, CDKN1A, GSTO2, SLC31A1, AKT2, BBC3, GSTA1, GSTA2, GSTA3, GSTA4, GSTM4, GSTM5, MSH6, BIRC2, XIAP, MAP3K5, MGST2, MGST3, PDPK1, PIK3CD, PIK3R1, PIK3R2, ATP7A, ATP7B, POLH, BCL2L1, REV3L, BID, TOP2B, TP53, PIK3R3, FADD, GSTO1, CDKN2A, ERBB2, ERCC1, AKT1, GSTM1, GSTM3, GSTP1, GSTT1, APAF1, BIRC5, FAS, FASLG, MDM2, MGST1, MLH1, MSH2, ATM, PIK3CA, PIK3CB, CYCS, MAPK1, MAPK3, BAD, BAK1, BAX, BCL2, BRCA1, TOP2A, TP53, XPA, CASP3, CASP8, CASP9, GSTM3, PIK3CB |
| Porphyrin and chlorophyll metabolism | UGT2B11, UGT2A1, EARS2, EPRS1, ALAD, ALAS1, FECH, FXN, GUSB, HCCS, HMBS, HMOX2, MMAB, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, BLVRA, BLVRB, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UROD, UROS, UGT2A3, HEPH, FYN, PIK3CA, PIK3CB |
| PPAR signaling pathway | SORBS1, ME3, SLC27A5, SLC27A4, SLC27A2, APOA5, PLIN2, CPT1C, CPT1A, CPT1B, CPT2, CYP4A11, CYP8B1, DBI, FABP3, FABP5, FABP6, FABP7, ACSL1, ACSL3, ACSL4, ACSBG1, ACSL6, GK, GK2, ACAA1, HMGCS1, HMGCS2, ACADL, APOA1, ACADM, APOC3, ILK, SLC27A1, LPL, ME1, OLR1, ACOX1, PCK2, ANGPTL4, PDPK1, ACSL5, PPARA, PPARD, RXRG, SCD, SCP2, UBC, UCP1, SCD5, ACSBG2, ACOX2, ACOX3, ADIPOQ, FADS2, CD36, NR1H3, AQP7, PLIN1, PLTP, PPARG, RXRA, RXRB, PLIN1, PLTP, RXRA, RXRB |
| Primary bile acid biosynthesis | CYP46A1, SLC27A5, AKR1C4, CYP8B1, AMACR, BAAT, SCP2, AKR1D1, HSD3B7, ACOX2, CH25H, PIK3CB |
| Primary immunodeficiency | ADA, TNFRSF13C, TNFRSF13B, AIRE, IGLL1, IL2RG, IL7R, JAK3, LCK, CIITA, PTPRC, RAG2, RFX5, RFXAP, DCLRE1C, TAP1, TAP2, BTK, UNG, ZAP70, IKBKG, RFXANK, CD3E, CD4, CD8B, CD19, CD40, RAG1, CD8A, CD79A |
| Prion diseases | STIP1, EGR1, ELK1, HSPA1A, LAMC1, NCAM2, NOTCH1, PRKACB, PRKACG, MAP2K1, MAP2K2, PRNP, C1QA, C1QB, C1QC, C5, C6, C7, C8G, FYN, HSPA1A, HSPA5, IL1A, IL1B, IL6, NCAM1, PRKACA, MAPK1, MAPK3, BAX, CCL5, SOD1, PRKACA |
| Progesterone-mediated oocyte maturation | AKT3, MAD2L2, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CPEB2, ADCY4, AKT2, CPEB3, SPDYA, CDC26, ANAPC13, GNAI2, GNAI3, SPDYE1, ANAPC2, ANAPC4, INS, KIF22, KRAS, SPDYE4, MAD2L1, MOS, SPDYE3, SPDYE5, FZR1, PDE3B, ANAPC5, ANAPC7, ANAPC11, PIK3CD, PIK3R1, PIK3R2, PLK1, PRKACB, PRKACG, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, RPS6KA1, RPS6KA2, MAPK12, CPEB1, ANAPC1, BRAF, STK10, BUB1, CPEB4, MAD1L1, PIK3R3, CCNB3, CDC23, CDC16, PKMYT1, CDC25B, CDC27, CDK2, ADCY1, ADCY2, ADCY3, MAPK14, AKT1, GNAI1, HSP90AA1, HSP90AB1, IGF1, IGF1R, PGR, PIK3CA, PIK3CB, PRKACA, MAPK1, MAPK3, MAPK8, RAF1, AURKA, CCNA2, CCNA1, CCNB1, CCNB2, CDK1, CDC25A, CDC25C, ADCY1, ADCY3, HSP90AB1, PIK3CB, PRKACA |
| Prolactin signaling pathway | AKT3, CISH, SOCS4, AKT2, ESR1, FOXO3, FOS, SHC2, GALT, GCK, GRB2, SOCS7, HRAS, INS, IRF1, JAK2, KRAS, SHC4, PIK3CD, PIK3R1, PIK3R2, SHC3, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, CCND1, RELA, MAPK12, SHC1, SOS2, STAT5A, STAT5B, TH, PIK3R3, SOCS1, TNFRSF11A, SOCS2, SOCS3, SOCS6, SOCS5, CGA, MAPK14, CYP17A1, ELF5, AKT1, ESR1, ESR2, GSK3B, LHB, LHCGR, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, PRL, PRLR, RAF1, SOS1, SRC, STAT1, STAT3, CCND2, ELF5, PIK3CB, CCND2 |
| Propanoate metabolism | ABAT, ECHS1, MLYCD, HIBCH, HADHA, ACACA, ACACB, ACADS, LDHB, ALDH6A1, PCCA, PCCB, ACOX1, ECHDC1, ACSS2, BCKDHA, BCKDHB, ACSS3, ACOX3, ACSS1, MCEE, SUCLG2, SUCLG1, SUCLA2, LDHAL6B, RAF1, SRC, LIPE, PLAT, DLD |
| Prostate cancer | AKT3, CDKN1A, CDKN1B, CREB3, CREBBP, E2F2, E2F3, EP300, ERG, AKT2, GRB2, HRAS, IKBKB, INS, INSRR, KRAS, ATF4, NFKBIA, NKX3-1, LEF1, PDGFA, PDGFB, PDGFRA, PDGFRB, PDPK1, PIK3CD, PIK3R1, PIK3R2, PDGFC, MAP2K1, MAP2K2, CCND1, RELA, CREB3L2, SOS2, SPINT1, BRAF, TCF7, ZEB1, TGFA, TMPRSS2, TP53, HSP90B1, PDGFD, TCF7L1, CREB3L3, PIK3R3, IKBKG, CCNE1, CCNE2, CREB5, CDK2, CREB1, CREB3L4, CTNNB1, E2F1, EGF, EGFR, ERBB2, AKT1, ETV5, FGFR1, FGFR2, FOXO1, MTOR, GSK3B, GSTP1, HSP90AA1, HSP90AB1, IGF1, IGF1R, KLK3, AR, MDM2, MMP9, NFKB1, PIK3CA, PIK3CB, PLAT, PLAU, MAPK1, MAPK3, BAD, PTEN, RAF1, RB1, BCL2, SOS1, SRD5A2, TCF7L2, TP53, IL1R2, CASP9, CREB1, CREB3L4, HSP90AB1, PIK3CB, TGFA |
| Proteasome | PSMD14, ADRM1, PSMA8, POMP, PSMA1, PSMA2, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMB10, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD7, PSMD8, PSMD9, PSMD12, PSMD13, PSME1, SEM1, PSMF1, PSMD6, ELANE, MET, MYC, MYCN, PSME3, PSME4 |
| Protein digestion and absorption | KCNE3, CELA3A, SLC7A9, SLC16A10, SLC36A4, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, COL7A1, COL9A1, COL9A2, COL9A3, COL11A1, COL11A2, COL12A1, COL13A1, COL15A1, COL17A1, COL6A6, CPA1, CPA2, CPA3, CTRB1, CTRL, SLC36A2, COL22A1, DPP4, ELN, SLC36A1, SLC7A8, CELA3B, COL24A1, COL6A5, SLC36A3, SLC6A19, COL28A1, KCNN4, MME, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, COL5A3, PGA5, SLC38A2, PRCP, PRSS3, CELA2A, SLC1A5, SLC3A1, SLC3A2, SLC8A2, SLC8A1, SLC8A3, SLC15A1, XPNPEP2, COL18A1, COL21A1, COL27A1, SLC7A7, COL1A1, KCNQ1, ACE2, SLC1A1, SLC9A3, KCNQ1, SLC1A1, SLC9A3 |
| Protein export | SEC61B, SEC63, IMMP1L, SEC11A, SEC61G, SPCS1, SEC61A1, OXA1L, SEC61A2, SRPRB, SPCS3, SRP9, SRP14, SRP19, SRP54, SRP68, SRP72, SRPRA, SEC62, IMMP2L, SEC11C, SPCS2, FYN |
| Protein processing in endoplasmic reticulum | PREB, PDIA6, BCAP31, STUB1, UBE4B, DNAJA2, MARCHF6, SEC24B, SEC23B, SEC23A, HYOU1, SEC24A, HSPH1, MAN1A2, SEC61B, OS9, LMAN2, CKAP4, SEC63, UBE2J2, TRAM1L1, ATF6B, CRYAA, CRYAB, DAD1, DDIT3, DDOST, EIF2S1, STT3B, ERN1, SEC31A, TRAM1, SEC61G, PPP1R15A, SVIP, SEC31B, FBXO2, FBXO6, AMFR, EIF2AK1, ERLEC1, DNAJC5G, SEC61A1, ERO1A, DNAJB2, HSPA1A, HSPA6, HSPA8, DNAJB1, STT3A, LMAN1, MAN1A1, MAP3K5, ATXN3, ATF4, P4HB, UBQLN3, PRKN, DERL2, SAR1B, MBTPS2, UBE2D4, DNAJB11, DNAJC10, DNAJB12, SEC61A2, YOD1, NPLOC4, EDEM2, UGGT2, NGLY1, SELENOS, PRKCSH, NSFL1C, MAPK9, MAPK10, MAP2K7, EIF2AK2, DNAJC3, ERO1B, SAR1A, UGGT1, UBQLN4, MAN1C1, BAG1, RPN1, RPN2, RRBP1, SEC13, SEL1L, DNAJC1, SIL1, SKP1, SSR1, SSR2, SSR3, SSR4, SEC62, HSP90B1, TRAF2, UBE2D1, UBE2D3, UBE2G1, UFD1, XBP1, DERL1, LMAN1L, EDEM3, DNAJC5, SEL1L2, UBXN6, CALR, TXNDC5, CANX, CAPN1, CAPN2, SYVN1, CUL1, DNAJC5B, MBTPS1, DERL3, RNF185, PLAA, EIF2AK3, PDIA4, SEC24C, EDEM1, HERPUD1, SEC24D, RBX1, PIK3CA, PIK3CB, RAF1, RAF1, RAP1A, RAF1, ND4, RAB3A, JUN, PIK3CA, |
| Proteoglycans in cancer | AKT3, CDKN1A, VAV3, FRS2, HPSE, COL1A2, CTSL, HBEGF, EIF4B, ELK1, CTTN, ERBB3, AKT2, ESR1, FGF2, RRAS2, MRAS, FLNB, FLNC, ARHGEF12, FZD2, GAB1, GPC3, PDCD4, GPC1, ANK2, ANK3, GRB2, HCLS1, HOXD10, HRAS, HSPG2, IHH, ITGA2, ITGB3, ITGB5, ITPR1, ITPR2, ITPR3, KRAS, NANOGP8, MIR10A, MIR10B, SMAD2, MSN, PPP1R12A, PPP1R12B, PLCE1, WNT16, PDPK1, PIK3CD, PIK3R1, PIK3R2, PLCG2, WNT4, PPP1R12C, PPP1CB, PRKACB, PRKACG, PRKCB, PRKCG, MAPK11, MAPK13, MAP2K1, MAP2K2, PTCH1, PTK2, PTPN6, PXN, RAC1, CCND1, RDX, HPSE2, ROCK1, RPS6, RPS6KB1, RPS6KB2, RRAS, MAPK12, SDC1, SDC2, SDC4, SLC9A1, SMO, SOS2, BRAF, TFAP4, TGFB2, THBS1, TIAM1, TIMP3, ACTG1, TNF, TP53, TWIST1, VAV1, VAV2, VTN, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, WNT10A, WNT5B, CAMK2A, CAMK2B, CAMK2D, CAMK2G, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, PIK3R3, CAV1, CAV2, CAV3, CBL, IQGAP1, WNT3A, ARHGEF1, ROCK2, CD63, COL1A1, MAPK14, CTNNB1, DCN, EGFR, ERBB2, ERBB4, AKT1, ESR1, FGFR1, FN1, MTOR, ANK1, DROSHA, HGF, HIF1A, IGF1, IGF1R, I |
| Proximal tubule bicarbonate reclamation | SLC38A3, SLC25A10, GLS2, GLS, GLUD1, GLUD2, AQP1, MDH1, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, PCK2, CA4, SLC4A4, SLC9A3, CA2, SLC9A3 |
| Purine metabolism | ADA, NT5C1B-RDH14, NME6, AK6, PAICS, PDE10A, ADCY5, NUDT5, ADCY6, ADCY7, ADCY8, ADCY9, NT5C3B, AK7, ADSS1, CANT1, NUDT16, ADK, ADSL, AK8, ADSS2, DCK, DGUOK, ADCY4, AK1, AK2, AK4, AK9, PRPS1L1, FHIT, NT5C2, GART, AK5, AMPD2, PDE7B, AMPD3, GMPR, GUCY1A2, GUCY1A1, GUCY1B1, GUCY2F, GUK1, NME7, GUCY2D, NT5C, NUDT2, HPRT1, APRT, IMPDH1, IMPDH2, ITPA, HDDC3, ENTPD8, ATIC, NME1, NME2, NME3, NME4, PNP, NPR1, NPR2, NT5E, RRM2B, AK3, PDE11A, GMPR2, PDE1A, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE6A, PDE6D, PDE6G, PDE7A, PDE8A, PDE9A, PDE1B, PDE6B, ENPP1, ENPP3, PFAS, PGM1, PKLR, PKM, NUDT9, PPAT, PGM2, ALLC, PRPS1, NT5M, ADPRM, PRUNE1, RRM1, RRM2, URAD, NME1-NME2, NTPCR, NT5C1A, PDE8B, PDE5A, GMPS, PAPSS2, NT5C1B, ENTPD2, ENTPD3, ENTPD5, ENTPD4, GDA, PIK3CA, PIK3CB, RAF1, JUN, SRC, MYC, PTTG1, PTTG1, JUN, ADCY1, ADCY3, PDE4A, ENTPD1, ENTPD6 |
| Pyrimidine metabolism | NT5C1B-RDH14, NME6, NT5C3B, CANT1, UPRT, CTPS1, UPP2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, TYMP, AK9, NT5C2, NME7, NT5C, NUDT2, ENTPD8, NME1, NME2, NME3, NME4, PNP, NT5E, RRM2B, ENPP1, ENPP3, CMPK1, UPB1, UCKL1, CTPS2, NT5M, RRM1, RRM2, NME1-NME2, TK1, TK2, TYMS, UCK2, UMPS, UPP1, CAD, DCTPP1, UCK1, NT5C1A, NT5C1B, ENTPD3, ENTPD5, ENTPD4, CDA, MCL1, PIK3CA, ENTPD1, ENTPD6 |
| Pyruvate metabolism | ME3, DLAT, LDHD, ALDH2, ALDH9A1, ALDH3A2, FH, GLO1, HAGH, ACACA, ACACB, LDHB, MDH1, MDH2, ME1, ME2, PC, PCK2, PDHA1, PDHB, PKLR, PKM, ACSS2, ACSS1, LDHAL6B, GRHPR, ACYP1, ACYP2, RAF1, SRC, JUN, MYC, MYC, DLD, PDHA2 |
| Rap1 signaling pathway | AKT3, RASGRP2, RAPGEF3, VAV3, RGS14, RAPGEF4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, CNR1, ADORA2A, ADORA2B, CRK, CRKL, CSF1R, CTNND1, CALML6, DRD2, LPAR1, EFNA1, EFNA2, EFNA3, EFNA5, ADCY4, EPHA2, AKT2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, MRAS, SIPA1L3, FLT4, LPAR3, PRKD3, FYB1, RASGRP3, PRKD2, MAGI3, FGF20, FGF21, FGF22, LAT, GNAI2, GNAI3, GNAQ, ANGPT1, LPAR4, ANGPT2, RAPGEF1, GRIN1, GRIN2A, GRIN2B, HRAS, PFN3, INS, ITGA2B, ITGAL, ITGAM, ITGB2, ITGB3, KRAS, LCP2, AFDN, NGFR, P2RY1, PARD6A, PLCE1, ANGPT4, EVL, PDGFA, PDGFB, PDGFRA, PDGFRB, RAPGEF6, CALML5, PFN2, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, ENAH, PRKCB, PRKCG, PRKD1, PRKCZ, MAPK11, MAPK13, PDGFC, MAP2K1, MAP2K2, MAP2K3, MAP2K6, PARD3, LPAR5, SIPA1L2, RAC1, RAC2, RAC3, RALA, RALB, RALGDS, RAP1B, RAP1GAP, RRAS, MAPK12, ARAP3, SIPA1, BRAF, TEK, THBS1, TIAM1, TLN1, ACTG1, VASP, VAV1, VAV2, VEGFB, VEGFC, PDGFD, CALM2, FGF23, CALM3, CALML3, RASSF5, TLN2, PARD6G, PARD6B, PIK3R3, SKAP1, FGF18, KRIT1, F2RL3, LPAR2, CALML4, MAGI1, BCAR1, RAPGEF2, DOCK4, F |
| Ras signaling pathway | AKT3, RASA4B, RASGRP1, RASA4, RASGRP2, PAK4, GNB5, RALBP1, PLAAT3, RASGRP4, CSF1R, CALML6, EFNA1, EFNA2, EFNA3, EFNA5, EPHA2, ELK1, AKT2, ETS1, ETS2, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, RRAS2, MRAS, RASA3, RGL1, FLT3LG, FLT4, ABL1, GAB1, SHC2, RASGRP3, PLA2G2D, FGF20, FGF21, ABL2, FGF22, LAT, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, KSR2, ANGPT1, ANGPT2, GRB2, GRIN1, GRIN2A, GRIN2B, TBK1, HRAS, HTR7, IKBKB, INS, ARF6, KRAS, SHC4, AFDN, FOXO4, NF1, NGFR, NTF3, NTF4, NTRK2, PLA2G3, PAK3, PLCE1, PLA1A, ANGPT4, PDGFA, PDGFB, PDGFRA, PDGFRB, GNG13, CALML5, PIK3CD, PIK3R1, PIK3R2, PLA2G1B, PLA2G4A, PLA2G5, SHC3, PLCG2, PLD1, PLD2, GNG2, PRKACB, PRKACG, EXOC2, PRKCB, PRKCG, GNG12, MAPK9, MAPK10, PDGFC, MAP2K1, MAP2K2, PAK6, PAK5, RGL2, RAB5A, RAB5B, RAB5C, RAC1, RAC2, RAC3, RALA, RALB, RALGDS, RAP1B, RASA1, RASA2, RASGRF1, RASGRF2, GNB4, REL, RELA, BCL2L1, RRAS, SHC1, RASAL3, SOS2, STK4, TEK, TGFA, TIAM1, VEGFB, VEGFC, ZAP70, PDGFD, SHOC2, CALM2, FGF23, CALM3, CALML3, PLA2G12A, B |
| Regulation of actin cytoskeleton | ARPC5, ARPC4, ARPC3, ARPC1B, ABI2, WASF2, APC2, PAK4, MYL12B, VAV3, BAIAP2, ARPC1A, MYL12A, CFL2, NCKAP1, IQGAP2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, IQGAP3, CRK, CRKL, DIAPH1, DIAPH2, DOCK1, LPAR1, PIKFYVE, F2, SPATA13, FGF1, FGF2, FGF5, FGF6, FGF7, FGF10, FGFR4, RRAS2, ITGA11, MRAS, CYFIP1, ARHGEF12, PIP5K1C, FGF20, FGF21, CYFIP2, FGF22, GNA12, LPAR4, GIT1, ARHGAP35, NCKAP1L, APC, HRAS, MYLK4, PFN3, INS, INSRR, ITGA2, ITGA2B, ITGA3, ITGA7, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAX, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, MOS, MSN, MYH9, MYH10, MYL2, MYL5, MYLK, PPP1R12A, PPP1R12B, PAK3, ARHGEF4, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN2, PIK3CD, PIK3R1, PIK3R2, PIP4K2A, SSH1, PPP1R12C, SSH3, PPP1CB, ENAH, GNG12, PDGFC, MAP2K1, MAP2K2, PAK6, LPAR5, PAK5, PTK2, PXN, RAC1, RAC2, RAC3, RDX, ROCK1, BDKRB1, RRAS, BDKRB2, CXCL12, SLC9A1, SOS2, BRAF, TIAM1, ACTG1, VAV1, VAV2, VCL, CXCR4, MYH14, PIP4K2C, PDGFD, FGF23, ACTN4, DIAPH3, ARPC5L, PIP5K1A, PIP5K1B, PIP4K2B, PIK3R3, ITGA10, ITGA8, MYLK2, SSH2, |
| Regulation of lipolysis in adipocytes | AKT3, ADCY5, PLAAT3, ADCY6, ADCY7, MGLL, ADCY8, ADCY9, ADRB1, ADRB2, ADRB3, ADCY4, AKT2, GNAI2, GNAI3, INS, IRS1, NPY, NPR1, NPY1R, ABHD5, PDE3B, PIK3CD, PIK3R1, PIK3R2, PRKACB, PRKACG, PRKG1, PTGER3, TSHB, TSHR, IRS4, PIK3R3, IRS2, ADCY1, ADCY2, CGA, ADCY3, AKT1, GNAI1, GNAS, AQP7, INSR, LIPE, PIK3CA, PIK3CB, PLIN1, PRKACA, PTGS1, PTGS2, ADCY1, ADCY3, PIK3CB, PLIN1, PRKACA |
| Relaxin signaling pathway | AKT3, CREB3, GNB5, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, COL1A2, COL3A1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, ATF2, ATF6B, EDN1, EDNRB, ADCY4, AKT2, FOS, SHC2, GNA15, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRB2, HRAS, RXFP4, KRAS, SHC4, SMAD2, ARRB2, MMP13, ATF4, NFKBIA, GNG13, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, SHC3, GNG2, PRKACB, PRKACG, PRKCZ, GNG12, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K7, ACTA2, GNB4, RXFP1, RELA, RLN1, RLN2, MAPK12, MAP2K4, SHC1, CREB3L2, SOS2, TGFBR1, TGFBR2, VEGFB, VEGFC, CREB3L3, PIK3R3, GNG8, CREB5, ADCY1, ADCY2, ADCY3, RXFP2, COL1A1, CREB1, MAPK14, CREB3L4, EGFR, AKT1, PLCB1, GNAI1, GNAO1, GNAS, INSL3, JUN, MMP2, MMP9, NFKB1, NOS2, NOS3, PIK3CA, PIK3CB, PRKACA, PRKCA, MAPK1, MAPK3, MAPK8, RAF1, SOS1, SRC, TGFB1, VEGFA, ADCY1, ADCY3, CREB1, CREB3L4, PIK3CB, PRKACA, PRKCA |
| Renal cell carcinoma | AKT3, CDKN1A, PAK4, EGLN2, CREBBP, CRK, CRKL, FLCN, EP300, EPAS1, AKT2, ETS1, FH, GAB1, GRB2, RAPGEF1, HRAS, KRAS, PAK3, PDGFB, PIK3CD, PIK3R1, PIK3R2, EGLN1, MAP2K1, MAP2K2, PAK6, PAK5, RAC1, RAP1B, SOS2, BRAF, ELOC, ELOB, TFE3, TGFA, TGFB2, VHL, CUL2, PIK3R3, RBX1, AKT1, HGF, HIF1A, JUN, MET, PAK1, PIK3CA, PIK3CB, MAPK1, MAPK3, BAD, PTPN11, RAF1, RAP1A, SLC2A1, SOS1, TGFB1, TGFB3, VEGFA, ARNT2, CDC42, PIK3CB, SLC2A1, TGFA |
| Renin secretion | ADCY5, ADCY6, ADCYAP1R1, CTSB, ADRB1, ADRB2, ADRB3, CALML6, AGT, AGTR1, EDN1, EDN3, GNAI2, GNAI3, GNAQ, GUCY1A2, GUCY1A1, GUCY1B1, AQP1, ITPR1, ITPR2, ITPR3, KCNJ2, KCNMA1, NPR1, PDE1A, PDE1C, PDE3A, PDE3B, PDE1B, CALML5, PLCB2, PLCB3, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACB, PRKACG, PTGER2, PTGER4, CACNA1C, CACNA1D, CALM2, CALM3, CALML3, CALML4, ADCYAP1, CREB1, ACE, EDNRA, CLCA4, PLCB1, GNAI1, GNAS, PRKACA, CACNA1S, CALM1, CREB1, PRKACA, CALM1 |
| Renin-angiotensin system | ATP6AP2, CPA3, CTSG, AGT, AGTR1, ENPEP, ANPEP, KLK1, KLK2, LNPEP, MME, CTSA, PRCP, PREP, NLN, THOP1, ACE, MAS1, ACE2 |
| Retinol metabolism | DHRS9, UGT2B11, UGT2A1, ADH1A, ADH1B, ADH4, ADH5, ADH6, RDH12, CYP2A6, CYP2C8, CYP2C9, CYP2C18, RDH10, CYP3A5, CYP4A11, CYP26A1, ALDH1A1, CYP2S1, AOX1, CYP26C1, RDH8, RDH11, BCO1, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, RETSAT, UGT2A2, RDH5, RPE65, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, UGT2A3, PNPLA4, HSD17B6, DGAT1, DHRS3, MUC5B, JUN, PIK3CA, PIK3CB, RAF1 |
| Retrograde endocannabinoid signaling | NDUFC2-KCTD14, GNB5, ADCY5, ADCY6, ADCY7, MGLL, ADCY8, ADCY9, NDUFA11, CNR1, SLC32A1, ADCY4, GABRR3, FAAH, DAGLB, NAPEPLD, RIMS1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GABRG1, GABRG2, GABRG3, GABRP, GABRR2, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, GRIA1, GRIA2, GRIA3, GRM1, GRM5, ITPR1, ITPR2, ITPR3, NDUFS7, KCNJ9, ND1, ND4L, ND5, ND6, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, GNG13, PLCB2, PLCB3, GNG2, NDUFB11, PRKACB, PRKACG, PRKCB, PRKCG, GABRQ, NDUFA12, GNG12, MAPK11, MAPK9, MAPK10, MAPK13, NDUFA4L2, SLC17A7, SLC17A6, ABHD6, GNB4, MAPK12, DAGLA, CACNA1A, CACNA1B, CACNA1C, CACNA1D, GNG8, ADCY1, ADCY2, ADCY3, MAPK14, PLCB1, GNAI1, GNAO1, KCNJ5, KCNJ6, ND4, NDUFS3, NDUFA13, PRKACA, PRKCA, MAPK1, MAPK3, MAPK8, PTGS2, CACNA1S, ADCY1 |
| Rheumatoid arthritis | TCIRG1, TNFSF13B, ATP6V1G3, CTLA4, CTSK, CTSL, ATP6V0E2, FOS, ATP6V1C2, ANGPT1, CXCL1, CXCL2, CXCL3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IL15, ITGAL, ITGB2, LTB, CCL3L3, ATP6V0A4, ATP6V1D, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V0B, ATP6V1G2, ATP6V0A1, ATP6AP1, CCL2, CCL3, CCL20, CXCL6, CXCL5, CXCL12, TEK, TGFB2, TNF, TNFSF13, TNFRSF11A, ATP6V0E1, ATP6V1E2, ATP6V0D1, ATP6V1F, CD28, CD80, CD86, ATP6V1G1, CSF1, FLT1, ATP6V0A2, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ICAM1, IFNG, IL1A, IL1B, IL6, CXCL8, IL11, IL17A, IL18, JUN, IL23A, CCL5, TGFB1, TGFB3, TLR2, TLR4, TNF, VEGFA |
| Riboflavin metabolism | ENPP1, ENPP3, ACP2, RFK, BLVRB, FLAD1, HLA-DRA |
| Ribosome | RPL17-C18orf32, RPL36A-HNRNPH2, MRPL28, MRPL3, RPL35, MRPL10, RPS4Y2, RPL10L, RPL22L1, FAU, MRPL21, RPL13A, RPL36, MRPL15, MRPL22, RPSA, RPL10A, MRPS16, MRPS18C, RPS27L, MRPL4, MRPS7, MRPS2, RPL26L1, RSL24D1, MRPL27, MRPL35, MRPS17, MRPS21, MRPL16, MRPL20, MRPS18A, RPL3, RPL3L, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10, RPL11, RPL12, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23A, MRPL23, RPL24, RPL26, RPL27, RPL30, RPL27A, RPL28, RPL29, RPL31, RPL32, RPL34, RPL35A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL41, RPL36A, RPLP0, RPLP1, RPLP2, MRPL12, MRPS12, RPS2, RPS3, RPS3A, RPS4X, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS27A, RPS28, RPS29, MRPL17, MRPS14, MRPL14, MRPS15, MRPS11, MRPS9, MRPS6, MRPL36, MRPL34, MRPL11, MRPL9, MRPL1, UBA52, MRPL24, RPL14, RPL23, MRPL33, MRPL19 |
| Ribosome biogenesis in eukaryotes | RCL1, MPHOSPH10, AK6, POP7, EMG1, NXF1, NOP56, RPP38, TBL3, POP4, UTP14A, POP1, WDR36, RPP25L, CSNK2A1, DKC1, FBL, XRN2, MDN1, GTPBP4, REXO2, GNL3, RRP7A, NOB1, NXT1, GNL2, FBLL1, EIF6, SNU13, NVL, FCF1, UTP18, SBDS, POP5, NOP58, GAR1, XRN1, GNL3L, RPP25, HEATR1, RBM28, NAT10, IMP3, LSG1, NOP10, NHP2, RIOK2, UTP6, NXT2, REXO1, PWP2, RAN, NOL6, TCOF1, XPO1, SNORD3A, EFL1, REXO5, RIOK1, WDR75, UTP4, IMP4, BMS1, RAP1A, PIK3CA, PIK3CB, PIK3CA, PIK3CB, SRC, SPATA5 |
| RIG-I-like receptor signaling pathway | TANK, CYLD, DDX3X, TKFC, TBK1, STING1, IFNA2, IFNA8, IFNA10, IFNA14, IFNW1, IKBKB, CXCL10, IRF3, IRF7, MAP3K1, NFKBIA, NFKBIB, PIN1, RNF125, OTUD5, MAPK11, MAPK9, MAPK10, MAPK13, MAVS, RELA, MAPK12, IFIH1, MAP3K7, TNF, TRAF2, TRAF3, TRAF6, TRIM25, DHX58, NLRX1, SIKE1, CASP10, IKBKG, TRADD, FADD, ATG12, ATG5, ISG15, IKBKE, TBKBP1, MAPK14, IFNA1, CXCL8, IL12A, NFKB1, MAPK8, TNF, CASP8 |
| RNA degradation | TOB1, MPHOSPH6, C1D, TOB2, BTG3, TENT4A, LSM6, EXOSC8, DIS3L, EXOSC6, NUDT16, PABPC5, DDX6, DCP2, DHX36, DCP1B, ENO2, ENO3, PATL1, XRN2, DIS3, EXOSC7, CNOT1, EXOSC2, MTREX, EDC4, CNOT6L, PAN3, LSM4, CNOT10, LSM1, LSM3, DCPS, CNOT2, CNOT3, CNOT4, PARN, EXOSC3, EXOSC1, LSM7, LSM8, PFKL, PFKM, PFKP, EXOSC9, XRN1, EXOSC4, BTG4, DCP1A, EXOSC5, CNOT6, LSM2, TENT4B, SKIV2L, BTG1, BTG2, EDC3, WDR61, ZCCHC7, PNPT1, PABPC4, CNOT9, CNOT8, TTC37, PAN2, PLAT, PLAU, BAX, BMI1, DICER1, MCL1, MET, MYC, PIK3CA, PIK3CB, PLAU, PNLDC1, LSM5, CNOT7, ENO4 |
| RNA polymerase | POLR3F, POLR3C, POLR3A, POLR3H, POLR1F, POLR1A, POLR1H, POLR1D, POLR3K, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3B, POLR3E, POLR1E, POLR3D, POLR1B, POLR3GL, POLR1C |
| RNA transport | POM121C, SNUPN, ALYREF, EIF1, POP7, SRRM1, SAP18, EIF1B, TACC3, NXF1, RPP38, PAIP1, NUP50, POP4, POP1, NUP42, RPP14, STRAP, DDX20, XPOT, CLNS1A, NUP35, RPP25L, PABPC5, EEF1A1, EEF1A2, EIF1AX, EIF2S1, EIF2B1, EIF2S3, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G2, EIF5, CASC3, NCBP2, ACIN1, NUP205, CYFIP1, NUP210, NUP160, NUP188, NUP62, GEMIN5, UPF2, CYFIP2, NXT1, NUP43, EIF3E, NCBP1, NUP88, NUP98, GEMIN4, TRNT1, POP5, NUP54, PNN, RPP25, GEMIN8, MAGOHB, ELAC1, NUP133, NXT2, NUP107, THOC2, RAN, RANBP2, SENP2, UPF1, ELAC2, SEC13, UPF3B, UPF3A, SMN2, SUMO3, SUMO2, TPR, UBE2I, XPO1, SNORD3A, NUP37, DDX39B, THOC6, GEMIN7, GEMIN6, RPP21, NUP85, THOC7, NUP214, AAAS, FXR1, SEH1L, PYM1, THOC3, RAE1, THOC5, EIF3A, EIF3B, EIF3C, EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, PABPC4, EIF2B4, EIF2B3, EIF2B2, EIF2B5, EIF2S2, EIF1AY, NUP210L, POM121L2, EIF4E2, FXR2, NUP155, EIF5B, TGS1, NUP93, EIF4A3, NUP58, POM121, RBM8A, NUP153, THOC1, JUN, PIK3CA, PIK3CB, RAF1, SRC, CGA, MYC, PIK3CA, PIK3CB, RAF1, SRC, RAF1, KIT, PRM |
| Salivary secretion | ADCY5, ADCY6, ADCY7, CHRM3, ADCY8, ADCY9, ADRA1D, ADRA1B, CST2, CST4, CST5, ADRA1A, ADRB1, ADRB2, ADRB3, CALML6, DMBT1, ADCY4, GNAQ, GUCY1A2, GUCY1A1, GUCY1B1, HTN3, ITPR1, ITPR2, ITPR3, KCNMA1, KCNN4, MUC7, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2B1, ATP2B2, ATP2B3, CALML5, PLCB2, PLCB3, TRPV6, PRH1, PRKACB, PRKACG, PRKCB, PRKCG, PRKG1, SLC4A2, SLC9A1, SLC12A2, STATH, BST1, CALM2, CALM3, CALML3, CAMP, LYZL1, CALML4, CD38, ADCY1, ADCY2, ADCY3, CST3, PLCB1, AMY1A, GNAS, AQP5, LPO, LYZ, ATP2B4, PRKACA, PRKCA, RYR3, VAMP2, MUC5B, CALM1, ADCY1, ADCY3, AMY1A, ATP2B4, PRKACA, PRKCA, RYR3, VAMP2, CALM1 |
| Salmonella infection | AKT3, ABI1, ARPC5, ARPC4, ARPC3, ARPC1B, TLR6, MYL12B, NOD1, TAB1, ARPC1A, MYL12A, EXOC5, NCKAP1, WASF3, RIPK3, SNX18, AHNAK2, NLRP3, TIRAP, FGD4, MYL6B, DYNLL2, CSE1L, KLC3, DYNC1I1, DYNC1I2, DYNC1LI2, AKT2, TAB2, FLNB, FLNC, CYFIP1, PLEKHM2, EXOC7, VPS39, FOS, LY96, SNX33, TAB3, TXN2, ARHGEF26, FBXO22, CYFIP2, VPS41, CYTH4, PYCARD, FHOD1, NCKAP1L, HRAS, BIRC2, PFN3, IKBKB, IRAK1, ARF1, ARF6, KLC1, KPNA1, KPNA3, KPNA4, RHOG, RHOH, M6PR, MYD88, MYH1, MYH2, MYH3, MYH8, MYH9, MYH10, MYH11, MYL6, MYO6, NAIP, NFKBIA, PAK3, IRAK4, DYNC1LI1, LEF1, RAB9B, SNX9, DYNC2LI1, PFN2, PIK3C3, TLR9, PODXL, EXOC2, PKN1, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, RHOJ, VPS18, MYH7B, PTPRC, RAB5A, RAB5B, RAB5C, RAC1, RALA, RELA, EXOC4, RPS3, RRAS, S100A10, MAPK12, MAP2K4, VPS16, ACBD3, KLC2, SKP1, VPS33A, MAP3K7, TCF7, DYNLT3, ACTG1, TLR5, TNF, HSP90B1, TRAF2, TRAF6, RAB7A, AHNAK, FYCO1, MYH14, GSDMD, ARPC5L, TCF7L1, RILP, DYNLRB2, DYNLRB1, CASP7, IKBKG, STX10, TRADD, MYH13, RIPK2, FADD, TNFRSF10B, T |
| Selenocompound metabolism | TXNRD2, INMT, PSTK, CTH, SEPHS2, SEPHS1, MARS1, SEPSECS, SCLY, TXNRD1, KYAT1, PAPSS2, RAP1A |
| Serotonergic synapse | RAPGEF3, GNB5, ADCY5, TPH2, CYP2C19, CYP2C8, CYP2C9, CYP2C18, CYP2D7, CYP2D6, CYP2J2, DDC, DUSP1, ALOX5, ALOX12B, ALOX15B, GABRB1, GABRB2, GABRB3, CYP4X1, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNGT1, GNGT2, HTR3E, HRAS, HTR1B, HTR1E, HTR2B, HTR2C, HTR3A, HTR5A, HTR6, HTR7, ITPR1, ITPR2, ITPR3, KCND2, KCNJ9, KCNN2, KRAS, GNG13, PLA2G4A, PLCB2, PLCB3, GNG2, PRKACB, PRKACG, PRKCB, PRKCG, GNG12, MAP2K1, GNB4, SLC6A4, SLC18A2, BRAF, TPH1, TRPC1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, PLA2G4C, HTR3B, GNG8, PLCB1, ALOX15, GNAI1, GNAO1, GNAS, HTR2A, APP, KCNJ5, KCNJ6, MAOA, PRKACA, PRKCA, MAPK1, MAPK3, PTGS1, PTGS2, RAF1, SLC18A1, CACNA1S, CASP3, HTR2A, KCNJ5, KCNJ6, PRKACA, PRKCA, SLC18A1 |
| Shigellosis | AKT3, ARPC5, ARPC4, ARPC3, ARPC1B, WASF2, CALCOCO2, TNIP1, RRAGB, MYL12B, NOD1, TAB1, ARPC1A, RBCK1, MYL12A, RRAGA, SEPTIN9, CBX3, GABARAP, GABARAPL2, NLRP3, CGAS, H3C14, CRK, CRKL, DIAPH1, DOCK1, U2AF1L4, CTTN, AKT2, FNBP1, FOXO3, TAB2, SEPTIN8, FBXW11, GABARAPL1, ABL1, TAB3, TECPR1, WIPI2, PYCARD, TBK1, H3-3A, H3-3B, HCLS1, PIK3R4, HK2, HK3, STING1, PFN3, IKBKB, IL1R1, ILK, IRF3, ITPR1, ITPR2, ITPR3, ARF1, UBE2NL, FOXO4, MYD88, MYL2, MYL5, NAIP, SEPTIN2, NFKBIA, NFKBIB, PLCE1, UBE2D4, PFN2, PIK3C3, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PLCD1, PLCG2, PPID, FNBP1L, ATG16L1, WIPI1, RNF31, SEPTIN11, PRKCD, PRKCE, PRKCQ, SEPTIN3, MAPK11, MAPK9, MAPK10, MAPK13, PTK2, RPTOR, PXN, RRAGD, RAC1, RELA, BCL2L1, ROCK1, RPS6KB1, RPS6KB2, RPS27A, MAPK12, ELMO2, SKP1, BNIP3, MAP3K7, TLN1, ACTG1, TLR5, TNF, TP53, TRAF2, TRAF5, TRAF6, U2AF1, UBA52, UBB, UBC, UBE2D1, UBE2D3, UBE2N, UBE2V1, UBE2V2, VCL, HKDC1, ACTN4, SHARPIN, ARPC5L, CAPN1, CAPN2, CAPNS1, CAST, H3C4, H3C3, H3C6, H3C11, H3C12, H3C10, H3C2, TLN2, AKT1S1, CUL1, P |
| Signaling pathways regulating pluripotency of stem cells | AKT3, COMMD3-BMI1, APC2, PCGF3, LEFTY1, ACVR1C, DLX5, DUSP9, DVL1, DVL2, DVL3, AKT2, ESRRB, FGF2, FGFR4, FZD2, GRB2, ONECUT1, HOXD1, APC, HRAS, ID2, ID3, ID4, INHBC, ISL1, JAK1, JAK2, JAK3, JARID2, KRAS, NANOGP8, LIFR, SMAD2, SMAD3, SMAD4, SMAD5, SMAD9, MEIS1, ZFHX3, NEUROG1, WNT16, PIK3CD, PIK3R1, PIK3R2, WNT4, RIF1, MAPK11, MAPK13, MAP2K1, MAP2K2, SMARCAD1, REST, MAPK12, LHX5, SKIL, BMPR1A, TBX3, TCF7, LEFTY2, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, ZIC3, PCGF2, FZD5, FZD3, KAT6A, WNT10A, WNT5B, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, INHBE, PCGF5, PCGF1, PIK3R3, HESX1, WNT3A, ACVR1, ACVR1B, ACVR2A, ACVR2B, KLF4, SETDB1, MAPK14, CTNNB1, AKT1, FGFR1, FGFR3, FGFR2, GSK3B, IGF1, IGF1R, IL6ST, INHBA, INHBB, LIF, SMAD1, MYC, NODAL, OTX1, PIK3CA, PIK3CB, POU5F1, MAPK1, MAPK3, RAF1, BMI1, BMP4, BMPR1B, BMPR2, SOX2, STAT3, TCF3, WNT5A, NANOG, ESX1, SMAD1, PIK3CB, BMI1, TCF3 |
| Small cell lung cancer | AKT3, CDK6, CDKN1A, CDKN1B, CDKN2B, LAMC3, CKS1B, CKS2, COL4A1, COL4A2, COL4A3, COL4A4, COL4A6, DDB2, GADD45A, E2F2, E2F3, AKT2, FHIT, BIRC2, XIAP, IKBKB, ITGA2, ITGA2B, ITGA3, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, MAX, GADD45B, NFKBIA, POLK, PIK3CD, PIK3R1, PIK3R2, PTK2, RARB, CCND1, RELA, BCL2L1, RXRG, SKP2, TP53, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, ZBTB17, BIRC7, PIK3R3, IKBKG, CCNE1, CCNE2, TRAF4, CDK2, GADD45G, E2F1, AKT1, FN1, APAF1, ITGA6, ITGAV, ITGB1, LAMA2, MYC, NFKB1, NOS2, PIK3CA, PIK3CB, CYCS, PTEN, PTGS2, BAK1, BAX, RB1, BCL2, RXRA, RXRB, TP53, CASP3, CASP9, GADD45G, LAMA2, PIK3CB, RXRA, RXRB |
| SNARE interactions in vesicular transport | BET1, VTI1B, YKT6, VAMP5, STX1B, VTI1A, BET1L, STX18, STX17, USE1, BNIP1, STX3, STX4, STX5, VAMP1, VAMP7, STX7, VAMP8, VAMP4, STX16, STX11, SNAP23, VAMP3, SNAP29, STX8, GOSR1, SEC22B, GOSR2, PIK3CB, BAX, PIK3CA, STX2, STX1A, VAMP2 |
| Sphingolipid metabolism | SPTLC1, CERS1, DEGS2, ACER1, NEU4, SGPP2, SGMS2, CERS3, CERS6, GALC, GLA, ENPP7, ACER2, NEU1, NEU2, SPTLC3, ACER3, SMPD3, SMPD4, ASAH2, SPHK2, GBA2, CERK, SMPD1, SMPD2, UGCG, UGT8, CERS4, SGPP1, DEGS1, PLPP1, PLPP2, PLPP3, CERS5, B4GALT6, SPTLC2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, SGMS1 |
| Sphingolipid signaling pathway | AKT3, SPTLC1, CERS1, DEGS2, ACER1, SGPP2, ADORA3, SGMS2, S1PR1, S1PR3, CERS3, AKT2, FCER1A, MS4A2, FCER1G, CERS6, GNA12, GNAI2, GNAI3, GNAQ, HRAS, ACER2, KRAS, MAP3K5, OPRD1, PDPK1, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PLD1, PLD2, S1PR5, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R5A, PPP2R5C, PPP2R5D, PPP2R5E, SPTLC3, PRKCB, PRKCE, PRKCG, PPP2R2D, PRKCZ, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, ASAH2, SPHK2, RAC1, RAC2, RAC3, RELA, ROCK1, BDKRB2, MAPK12, BID, SMPD1, SMPD2, TNF, TP53, TRAF2, CERS4, SGPP1, NSMAF, PIK3R3, DEGS1, S1PR4, TRADD, CERS5, S1PR2, ROCK2, SPTLC2, GAB2, GNA13, MAPK14, CTSD, AKT1, PLCB1, FYN, SGMS1, GNAI1, RHOA, ASAH1, ABCC1, NFKB1, NOS3, PIK3CA, PIK3CB, PPP2CB, PRKCA, MAPK1, MAPK3, MAPK8, PTEN, BAX, RAF1, BCL2, TNF, TNFRSF1A, TP53, GNA13, SGMS1, GNA12, RHOA, PIK3CB, PPP2R3C, PPP2CB, PRKCA |
| Spinocerebellar ataxia | AKT3, PSMD14, KAT5, NOP56, AFG3L2, ADRM1, ATXN2L, OMA1, GRIN3A, GRIN3B, PSMA8, BEAN1, AKT2, ERN1, FGF14, ATG2A, CIC, ATXN10, WIPI2, GNAQ, GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GTF2B, NRBF2, PIK3R4, ATXN1L, RBPJ, ITPR1, ITPR2, ITPR3, KCNC3, KCND3, TBPL2, MAP3K5, ATXN3, MYOD1, NFYA, ATP2A1, ATP2A2, ATP2A3, OPA1, PDYN, PIK3C3, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, WIPI1, ATG2B, AMBRA1, PRKCB, PRKCG, MAPK9, MAPK10, RELN, PSMA1, PSMA2, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD7, PSMD8, PSMD9, PSMD12, PSMD13, ATG101, RORA, RYR1, ATXN1, ATXN2, SLC1A6, SPTBN2, TRAF2, TRPC3, VLDLR, XBP1, CACNA1A, SEM1, ULK1, PIK3R3, BECN1, PUM1, ULK2, ATG13, RB1CC1, PSMD6 |
| Spliceosome | ISY1-RAB43, PQBP1, ALYREF, SF3B4, SMNDC1, BCAS2, SF3A1, PPIE, PPIH, CHERP, SLU7, PRPF8, USP39, TXNL4A, TCERG1, SRSF8, SF3A3, SF3B2, SNRNP27, LSM6, DDX42, U2AF2, RBMXL3, CCDC12, DHX15, U2AF1L4, HNRNPA3, PUF60, NCBP2, SNW1, ACIN1, SNRNP200, U2SURP, SF3B3, SF3B1, PRPF6, LSM4, SYF2, PRPF31, LSM3, PRPF19, TRA2A, HNRNPA1, HNRNPC, HNRNPK, HNRNPU, HSPA1A, HSPA6, HSPA8, HNRNPCL1, HNRNPM, NCBP1, SNU13, RBMXL1, PCBP1, CRNKL1, CDC40, CWC15, SF3B6, PPIL1, LSM7, LSM8, WBP11, PLRG1, MAGOHB, PRPF38B, PRPF40A, RBM22, CTNNBL1, THOC2, ISY1, LSM2, RBM25, RP9, SRSF2, SRSF3, SRSF5, SRSF7, TRA2B, SNRNP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPC, SNRPD1, SNRPD2, SNRPE, SNRPF, SNRPG, U2AF1, DDX39B, SF3A2, THOC3, DHX16, PHF5A, PRPF38A, RBM17, PRPF18, BUD31, SART1, PRPF4, PRPF3, EFTUD2, SNRNP40, DDX23, AQR, EIF4A3, DDX46, CDC5L, RBM8A, THOC1, RAF1, SRC, PIK3CA, PIK3CB, RAF1, CGA, PIK3CA, PIK3CB, RAF1, SRC, JUN, RAF1, SRSF10, DDX5, LSM5, RBMXL2 |
| Staphylococcus aureus infection | MASP2, DEFA1, DEFA3, DEFA4, DEFA5, DEFB1, DEFB4A, CFD, DSG1, KRT24, FCAR, FCGR2A, FCGR2B, FCGR3B, FGG, FPR2, FPR3, KRT23, CFH, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, CFI, ITGAL, ITGAM, ITGB2, KRT9, KRT13, KRT14, KRT15, KRT17, KRT18, KRT19, KRT32, MBL2, PLG, KRT20, DEFB103B, MASP1, PTAFR, CFB, SELP, SELPLG, C1QA, C1QB, C1QC, C1R, C1S, C2, C3AR1, C5, C5AR1, CAMP, KRT38, FCGR2C, FCGR3A, FPR1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ICAM1, IL10, KRT10, C3 |
| Starch and sucrose metabolism | TREH, AGL, GANC, GBE1, GCK, GPI, PGM2L1, GYG1, GYS1, GYS2, HK2, HK3, ENPP1, ENPP3, PGM1, PGM2, G6PC2, PYGB, PYGL, PYGM, SI, UGP2, HKDC1, GYG2, MGAM, MGAM2, JUN, KIT, MET, MYC, RAF1, AMY1A, HK1 |
| Steroid biosynthesis | EBP, CYP2R1, CYP27B1, CYP51A1, DHCR7, DHCR24, FDFT1, LBR, LIPA, LSS, NSDHL, HSD17B7, MSMO1, SC5D, SOAT1, SQLE, TM7SF2, PIK3CA |
| Steroid hormone biosynthesis | UGT2B11, UGT2A1, AKR1C4, CYP2E1, CYP3A5, AKR1C1, AKR1C2, LRTOMT, HSD11B1, HSD11B2, HSD11B1L, STS, HSD17B12, HSD17B7, UGT2B28, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A3, UGT2A2, AKR1D1, SULT2B1, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, DHRS11, HSD17B8, SRD5A3, UGT2A3, HSD17B6, BAX, RAF1, CGA, JUN, LIPE, PIK3CA, PIK3CB, RAF1, RAP1A, RAF1, KIT, MCL1, MET, MYB, MYC, PIK3CA, PIK3CB, RAF1, RAB10 |
| Sulfur metabolism | ETHE1, MPST, BPNT2, SQOR, SUOX, TST, SELENBP1, PAPSS2 |
| Sulfur relay system | MOCS3, CTU2, MOCS2, MPST, TST, URM1, CTU1, NFS1 |
| Synaptic vesicle cycle | TCIRG1, UNC13B, CPLX2, CPLX1, STX1B, AP2M1, AP2S1, CLTA, CLTB, CLTC, ATP6V1G3, SLC32A1, ATP6V0E2, AP2A1, AP2A2, AP2B1, DNM1, RIMS1, UNC13A, ATP6V1C2, DNM3, UNC13C, NSF, ATP6V0A4, ATP6V1D, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V0B, ATP6V1G2, ATP6V0A1, SLC17A7, SLC17A6, CPLX3, SLC1A2, SLC1A3, SLC1A6, SLC1A7, SLC6A2, SLC6A3, SLC6A4, SLC6A7, SLC6A9, SLC6A11, SLC6A12, SLC6A13, SLC18A2, SLC18A3, SNAP25, STX3, SYT1, CACNA1A, CACNA1B, CLTCL1, NAPA, ATP6V0E1, ATP6V1E2, ATP6V0D1, SLC6A5, ATP6V1F, ATP6V1G1, DNM2, STX2, ATP6V0A2, RAB3A, SLC1A1, SLC6A1, SLC18A1, STX1A, STXBP1, VAMP2, STX2, RAB3A, SLC1A1, SLC6A1, SLC18A1, STX1A, STXBP1, VAMP2 |
| Synthesis and degradation of ketone bodies | HMGCL, HMGCS1, HMGCS2, OXCT1, HMGCLL1, BDH2, BDH1, OXCT2, FYN |
| Systemic lupus erythematosus | H3C14, H2BU1, CTSG, FCGR2A, FCGR3B, H2AC1, H2BW2, GRIN2A, GRIN2B, H2AC8, H2AC7, H2AZ1, H2BC5, H2BC3, H3-3A, H3-3B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, H2AC21, H2AB2, H2AB1, H4C15, MACROH2A2, H2AJ, SNRPB, SNRPD1, TRIM21, RO60, SSB, C1QA, TNF, C1QB, C1QC, C1R, C1S, C2, H2AC19, C5, C6, C7, C8G, ACTN4, H2AC13, H2AC15, H2AC16, H2AC6, H2AC4, H2AC17, H2AC18, H2AC20, H2BC8, H2BC15, H2BC6, H2BC9, H2BC10, H2BC4, H2BC17, H2BC21, H3C4, H3C3, H3C6, H3C11, H3C12, H3C10, H3C2, H4C1, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C5, H4C13, H4C7, H2AB3, H2AC12, H2BC12, ACTN1, CD28, CD80, CD86, H2AZ2, MACROH2A1, CD40, HIST4H4, H2BFWT, ELANE, FCGR3A, HIST1H2BA, H2AFX, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, IL10, TNF, C3, HIST3H3, H2BC1 |
| T cell receptor signaling pathway | AKT3, RASGRP1, PAK4, VAV3, MAP3K8, CTLA4, DLG1, AKT2, FOS, LAT, GRB2, HRAS, IKBKB, ITK, KRAS, LCK, LCP2, NCK1, NFATC1, NFATC2, NFATC3, NFKBIA, NFKBIB, NFKBIE, PAK3, PDPK1, PIK3CD, PIK3R1, PIK3R2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K7, PAK6, PAK5, PTPN6, PTPRC, RELA, MAPK12, SOS2, MAP3K7, TEC, TNF, VAV1, VAV2, ZAP70, NCK2, CARD11, PIK3R3, IKBKG, CBLB, BCL10, MAP3K14, CD3E, CD3G, CD247, CD4, CD8B, CD28, GRAP2, MALT1, MAPK14, AKT1, FYN, GSK3B, IFNG, IL2, IL4, IL5, IL10, JUN, RHOA, NFKB1, PAK1, PDCD1, PIK3CA, PIK3CB, PLCG1, MAPK1, MAPK3, MAPK8, RAF1, SOS1, TNF, CD8A, CDC42, RHOA, PIK3CB, PLCG1 |
| Taste transduction | HCN4, ADCY6, CHRM3, ADCY8, ADCY4, P2RX2, GABBR1, CALHM1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, TAS2R39, TAS2R19, TAS2R50, GNB3, HTR3E, GRM1, GRM4, TRPM5, HTR1B, HTR1E, HTR3A, TAS2R60, ITPR3, ASIC2, P2RX3, P2RY1, P2RY4, TAS2R1, TAS2R9, TAS2R8, PDE1A, PDE1C, PDE1B, GNG13, PLCB2, PRKACB, PRKACG, SCN2A, SCNN1A, SCNN1B, SCNN1G, CACNA1A, CACNA1C, TAS1R2, TAS1R1, TAS1R3, PKD2L1, HTR3B, ENTPD2, TAS2R43, TAS2R3, TAS2R14, PRKACA, TAS2R38, GABBR2, TAS2R43, TAS2R3, TAS2R14, PRKACA, GABBR2 |
| Taurine and hypotaurine metabolism | CDO1, GAD1, GAD2, GGT1, GGT7, GADL1, CSAD, BAAT, ADO |
| Terpenoid backbone biosynthesis | ZMPSTE24, PMVK, NUS1, FNTA, FNTB, PDSS1, HMGCR, HMGCS1, HMGCS2, IDI1, MVD, MVK, PCYOX1, PDSS2, RCE1, PIK3CA, PIK3CB, GGPS1 |
| TGF-beta signaling pathway | CDKN2B, LEFTY1, ACVR1C, CREBBP, HJV, GDF7, E2F4, E2F5, EP300, FBN1, BAMBI, GREM1, RGMB, ID2, ID3, ID4, INHBC, LTBP1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD9, NBL1, PITX2, PPP2CA, PPP2R1A, PPP2R1B, RGMA, HAMP, RBL1, TGIF2, ROCK1, RPS6KB1, RPS6KB2, GREM2, SMURF2, BMP2, SKP1, BMP5, BMP6, BMPR1A, TFDP1, TGFB2, LEFTY2, TGFBR1, TGFBR2, TGIF1, THBS1, TNF, THSD4, GDF5, INHBE, CUL1, CHRD, ACVR1, ACVR1B, ACVR2A, ACVR2B, ZFYVE9, ZFYVE16, RBX1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, JUN, MYC, PIK3CA, PIK3CB, BAX, PTTG1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, JUN, PIK3CA, PIK3CB, CYCS, BAX, RAF1, JUN, PIK3CA, PIK3CB, CYCS, BMP8A, RHOA, SMAD1, PPP2CB, SMURF1, BMP8B |
| Th1 and Th2 cell differentiation | DLL3, JAG1, FOS, GATA3, LAT, DLL1, TBX21, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IFNGR1, IFNGR2, RBPJ, IKBKB, IL2RB, IL2RG, IL4R, IL12RB1, IL12RB2, IL13, JAG2, JAK1, JAK2, JAK3, LCK, MAF, NFATC1, NFATC2, NFATC3, NFKBIA, NFKBIB, NFKBIE, NOTCH1, NOTCH3, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, MAML3, PRKCQ, MAPK11, MAPK9, MAPK10, MAPK13, RELA, MAPK12, STAT5A, STAT5B, STAT6, ZAP70, MAML2, IKBKG, CD3E, CD3G, CD247, CD4, MAML1, MAPK14, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, IL2, IL2RA, IL4, IL5, IL12A, JUN, NFKB1, PLCG1, MAPK1, MAPK3, MAPK8, STAT1, STAT4, TYK2, RUNX3, PLCG1 |
| Th17 cell differentiation | IL17F, IL23R, FOS, GATA3, LAT, TBX21, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IFNGR1, IFNGR2, IKBKB, IL1R1, IL1RAP, IL2RB, IL2RG, IL4R, IL12RB1, JAK1, JAK2, JAK3, LCK, SMAD2, SMAD3, SMAD4, NFATC1, NFATC2, NFATC3, NFKBIA, NFKBIB, NFKBIE, IL21R, IL17D, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, MAPK11, MAPK9, MAPK10, MAPK13, RARA, RELA, RORA, RORC, RXRG, MAPK12, STAT5A, STAT5B, STAT6, TGFBR1, TGFBR2, ZAP70, IKBKG, RUNX1, CD3E, CD3G, CD247, CD4, IL27RA, MAPK14, AHR, MTOR, HIF1A, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HSP90AA1, HSP90AB1, IFNG, IL1B, IL2, IL2RA, IL4, IL6, IL6R, IL6ST, IL17A, JUN, NFKB1, FOXP3, IL23A, PLCG1, MAPK1, MAPK3, MAPK8, IL21, RARA, RXRA, RXRB, STAT1, STAT3, TGFB1, TYK2, HSP90AB1, PLCG1, RARA, RXRA, RXRB |
| Thermogenesis | NDUFC2-KCTD14, COX17, ATP5PD, CREB3, ATP5MG, FRS2, PPARGC1A, UQCR11, ADCY5, ADCY6, ADCY7, MGLL, ADCY8, ADCY9, COX20, SLC25A29, COX6B2, CPT1C, NDUFA11, CNR1, COX4I1, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, COX11, CPT1A, CPT1B, CPT2, NDUFAF6, ATF2, CYC1, ADRB3, COX7B2, ADCY4, ACSL1, ACSL3, ACSL4, ACSL6, NDUFAF3, FGF21, UQCRQ, COX18, GRB2, UQCR10, HRAS, COX8C, NDUFS7, KRAS, MAP3K5, UQCRHL, COX2, ND1, ND4L, ND5, ND6, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFB1, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, NPR1, COA5, ATP5F1B, ATP5F1C, NDUFAF1, COX16, COA4, ATP5F1D, ATP5F1E, ACTL6B, PRKAG2, ATP5PB, SIRT6, ATP5MC1, ATP5MC2, ACSL5, KDM3B, ATP5MC3, ATP5ME, ATP5PF, ATP5PO, NDUFB11, NDUFAF7, PRKAA2, PRKAB1, PRKACB, PRKACG, COA1, PRKG1, NDUFA12, MAPK11, MAPK13, MAP2K3, NDUFA4L2, ARID1B, RPTOR, RHEB, RPS6, RPS6KA1, RPS6KA2, RPS6KB1, RPS |
| Thiamine metabolism | AK7, AK8, AK1, AK2, AK4, ALPI, ALPL, ALPP, AK5, TPK1, THTPA, NTPCR, NFS1, HLA-DQB1 |
| Thyroid cancer | CDKN1A, TFG, DDB2, GADD45A, HRAS, KRAS, GADD45B, LEF1, POLK, MAP2K1, MAP2K2, CCND1, RET, RXRG, BRAF, TCF7, TP53, TPM3, TPR, PAX8, CCDC6, NCOA4, TCF7L1, GADD45G, CTNNB1, MYC, NTRK1, PPARG, MAPK1, MAPK3, BAK1, BAX, RXRA, RXRB, TCF7L2, TP53, CDH1, GADD45G, RXRA, RXRB |
| Thyroid hormone signaling pathway | AKT3, MED16, RCAN2, MED12L, SLC16A10, CREBBP, DIO2, DIO3, RCAN1, EP300, AKT2, ESR1, MED13L, KAT2A, MED4, HDAC2, HRAS, ITGB3, KRAS, MYH6, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, NOTCH1, NOTCH3, NOTCH4, FXYD2, ATP2A1, ATP2A2, ATP2A3, PLCE1, PDPK1, PFKFB2, PFKL, PFKM, PFKP, PIK3CD, PIK3R1, PIK3R2, PLCB2, PLCB3, PLCD1, PLCG2, PLN, SLCO1C1, WNT4, PRKACB, PRKACG, PRKCB, PRKCG, MAP2K1, MAP2K2, CCND1, RHEB, RXRG, SLC9A1, THRA, ACTG1, TP53, TSC2, NCOA3, PLCD4, PIK3R3, NCOA1, HDAC3, KAT2B, MED30, MED14, MED27, NCOR1, MED24, TBC1D4, MED12, MED13, NCOA2, CTNNB1, AKT1, ESR1, FOXO1, PLCB1, MTOR, SIN3A, GATA4, GSK3B, HDAC1, HIF1A, ITGAV, MDM2, MYC, MYH7, PIK3CA, PIK3CB, PLCG1, MED1, PRKACA, PRKCA, MAPK1, MAPK3, BAD, RAF1, ACTB, RXRA, RXRB, SLC2A1, BMP4, SRC, STAT1, THRB, TP53, CASP9, PLCZ1, PIK3CB, PLCG1, MED1, PRKACA, PRKCA, RXRA, RXRB, SLC2A1 |
| Thyroid hormone synthesis | CREB3, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF2, ATF6B, ADCY4, GNAQ, GPX2, GPX3, GPX7, ITPR1, ITPR2, ITPR3, IYD, LRP2, DUOXA2, ASGR1, ASGR2, ATF4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2, DUOX2, SLC26A4, PLCB2, PLCB3, DUOX1, PRKACB, PRKACG, PRKCB, PRKCG, CREB3L2, SLC5A5, SERPINA7, TG, TPO, HSP90B1, TSHB, TSHR, TTF1, PAX8, CANX, TTF2, CREB3L3, CREB5, PDIA4, ADCY1, ADCY2, CGA, ADCY3, CREB1, CREB3L4, ALB, PLCB1, GNAS, GPX1, GPX5, GSR, HSPA5, PRKACA, PRKCA, ADCY1, ADCY3, CREB1, CREB3L4, GPX5, PRKACA, PRKCA |
| Tight junction | ACTR3, ACTR2, PATJ, MYL12B, MYL12A, CLDN16, BVES, TUBA3E, TUBA3D, SYNPO, CLDN4, CLDN7, CLDN23, MYL6B, AMOT, AMOTL1, DLG1, DLG2, DLG3, CTTN, NEDD4L, ARHGEF18, SCRIB, CLDN14, CLDN15, CLDN17, TJP3, HCLS1, LLGL2, LLGL1, MAP3K1, MAP3K5, RAB8A, AFDN, MSN, MYH1, MYH2, MYH3, MYH8, MYH9, MYH10, MYH11, MYL2, MYL6, NEDD4, F11R, PARD6A, CLDN18, AMOTL2, PRKAG2, RAPGEF6, RAB8B, EPB41L4B, ARHGAP17, PPP2CA, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKAA2, PRKAB1, PRKACB, PRKACG, PRKCE, PPP2R2D, PRKCZ, MAPK9, MAPK10, MAP2K7, PARD3, ACTR3B, CGN, MYH7B, RAP2C, JAM2, MPP4, RAC1, CCND1, RDX, ROCK1, ACTR3C, TIAM1, TJP1, ACTG1, CLDN5, VASP, WAS, CACNA1D, MICALL2, MYH14, TUBAL3, ACTN4, SYMPK, JAM3, PARD6G, PARD6B, TUBA1C, CGNL1, YBX3, RUNX1, ACTN1, MYH13, MPDZ, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, CD1C, CD1E, ARHGEF2, MARVELD3, MAGI1, CRB3, TJAP1, SLC9A3R1, ROCK2, RAPGEF2, CFTR, ERBB2, GATA4, HSPA4, ITGB1, JUN, RHOA, NF2, CLDN11, PCNA, TUBA8, PPP2CB, PRKAA1, PRKACA, MAPK8, RAP1A, ACTB, SRC, STK11, TUBA4A, TUBA3C, EZR, CD1D |
| TNF signaling pathway | AKT3, TAB1, CREB3, RIPK3, MAP3K8, ATF2, ATF6B, DAB2IP, JAG1, EDN1, PGAM5, AKT2, TAB2, FOS, TAB3, CXCL1, CXCL2, CXCL3, BIRC2, IKBKB, IL15, CXCL10, IRF1, JUNB, LTA, MAP3K5, MMP14, ATF4, NFKBIA, PIK3CD, PIK3R1, PIK3R2, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K3, MAP2K6, MAP2K7, RELA, BCL3, MAPK12, CCL2, CCL20, CXCL6, CXCL5, NOD2, MAP2K4, CREB3L2, MAP3K7, TNF, TRAF1, TRAF2, TRAF3, TRAF5, VCAM1, VEGFC, ITCH, CASP7, CASP10, CREB3L3, PIK3R3, IKBKG, TRADD, FADD, CFLAR, RPS6KA4, MAP3K14, SOCS3, RPS6KA5, BAG4, CREB5, DNM1L, CREB1, MAPK14, CSF1, CREB3L4, AKT1, ICAM1, FAS, IL1B, IL6, JUN, LIF, MMP9, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, PTGS2, CCL5, CX3CL1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, CASP3, CASP8, CREB1, CREB3L4, PIK3CB, TNFAIP3 |
| Toll-like receptor signaling pathway | AKT3, TLR6, TAB1, TIRAP, MAP3K8, TICAM1, CTSK, AKT2, TAB2, FOS, LY96, TBK1, IFNA2, IFNA8, IFNA10, IFNA14, IFNAR1, IKBKB, CXCL10, IRAK1, IRF3, IRF5, IRF7, LBP, CCL3L3, MYD88, NFKBIA, IRAK4, TLR7, PIK3CD, PIK3R1, PIK3R2, TLR9, TOLLIP, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, RAC1, RELA, MAPK12, CCL3, CXCL11, MAP2K4, SPP1, MAP3K7, TLR1, TLR3, TLR5, TNF, TRAF3, TRAF6, PIK3R3, IKBKG, FADD, CD80, CD86, CD40, IKBKE, MAPK14, TICAM1, AKT1, IFNA1, IFNAR2, IL1B, IL6, CXCL8, IL12A, JUN, NFKB1, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, CCL5, STAT1, TLR2, TLR4, TNF, CASP8, TICAM1, PIK3CB |
| Toxoplasmosis | AKT3, PPIF, LAMC3, TAB1, PIK3R6, AKT2, TAB2, PIK3R5, LY96, ALOX5, GNAI2, GNAI3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, BIRC2, HSPA1A, XIAP, HSPA6, HSPA8, IRGM, IFNGR1, IFNGR2, IKBKB, IL10RA, IL10RB, IRAK1, JAK1, JAK2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB3, LAMC1, LAMC2, LDLR, CIITA, MYD88, NFKBIA, NFKBIB, IRAK4, PDPK1, PIK3CG, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K3, MAP2K6, RELA, BCL2L1, MAPK12, MAP3K7, TGFB2, TNF, TRAF6, BIRC7, IKBKG, SOCS1, CD40, CCR5, MAPK14, AKT1, GNAI1, GNAO1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HSPA1A, HSPA1B, HSPA1L, HSPA2, IFNG, IL10, IL12A, ITGA6, ITGB1, LAMA2, NFKB1, NOS2, CYCS, MAPK1, MAPK3, MAPK8, BAD, BCL2, STAT1, STAT3, TGFB1, TGFB3, TLR2, TLR4, TNF, TNFRSF1A, TYK2, CASP3, CASP8, CASP9, LAMA2 |
| Transcriptional misregulation in cancer | COMMD3-BMI1, CDKN1A, CDKN1B, CDKN2C, CEBPE, H3C14, CSF1R, DDB2, GADD45A, DDIT3, DEFA3, ELK4, ERG, ETV1, ETV4, EWSR1, EYA1, FLI1, FUS, FUT8, NUPR1, GRIA3, GZMB, H3-3A, H3-3B, HDAC2, HHEX, TLX1, HOXA9, HOXA10, HOXA11, HPGD, ID2, IL2RB, IL3, ITGAM, ITGB7, JUP, LMO2, LYL1, MAF, MAX, MEF2C, MEIS1, MEN1, MITF, MLF1, KMT2A, MLLT1, AFF1, MLLT3, MPO, GADD45B, ATF1, NGFR, PAX5, PAX7, PBX1, PBX3, KLF3, WNT16, POLK, ETV7, PDGFA, SIX4, CDK14, PML, FEV, BMP2K, PTK2, RARA, REL, BCL2A1, RELA, BCL2L1, BCL6, RXRG, NFKBIZ, BCL11B, SIX1, SPI1, SPINT1, SSX1, SSX2, SS18, ZEB1, TFE3, TGFBR2, TMPRSS2, TP53, TRAF1, SSX2B, NSD2, ZBTB16, ZBTB17, PAX8, ASPSCR1, NR4A3, HMGA2, TAF15, H3C4, H3C3, H3C6, H3C11, H3C12, H3C10, H3C2, DOT1L, SUPT3H, RUNX2, RUNX1, RUNX1T1, LDB1, PER2, BAIAP3, CCNT1, CD86, CD40, NCOR1, CDK9, GADD45G, DUSP6, ELANE, ETV5, JMJD1C, FOXO1, FLT1, FLT3, SIN3A, HDAC1, IGF1, IGF1R, IGFBP3, IL6, CXCL8, SMAD1, MDM2, MET, MMP9, MYC, MYCN, ATM, NFKB1, NTRK1, PLAT, PLAU, PPARG, BAK1, BAX, RARA, RXRA, RXRB, BMI1, SP1, TCF3, TP53 |
| Tryptophan metabolism | INMT, TPH2, AFMID, AANAT, DDC, IDO2, DLST, ECHS1, ALDH2, ALDH9A1, ALDH3A2, HAAO, AOC1, GCDH, HADHA, HADH, AOX1, IDO1, AADAT, DHTKD1, ALDH8A1, TPH1, KYAT1, KYNU, HLA-DRB1, KIT, F3, PLAT, PLAU, PLAUR, FYN, PIK3CA, DLD, IL4I1 |
| Tuberculosis | AKT3, TCIRG1, TLR6, CEBPG, CORO1A, TIRAP, PLK3, CR1L, CREBBP, CTSS, CYP27B1, CALML6, EP300, AKT2, FCER1G, FCGR2A, FCGR2B, FCGR3B, PLA2R1, ARHGEF12, CD209, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, IFNA2, IFNA8, IFNA10, IFNA14, IFNGR1, IFNGR2, IL10RA, IL10RB, IRAK1, IRAK2, ITGAM, ITGAX, ITGB2, JAK1, JAK2, LAMP1, LAMP2, LBP, LSP1, CIITA, MRC1, MYD88, NFYA, NFYB, NFYC, ATP6V0A4, IRAK4, ATP6V1H, CALML5, ATP6V0C, PIK3C3, ATP6V0B, ATP6V0A1, ATP6AP1, TLR9, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, MAPK11, MAPK9, MAPK10, MAPK13, SPHK2, RAB5A, RAB5B, RAB5C, RELA, RFX5, RFXAP, MAPK12, BID, NOD2, CARD9, SYK, TGFB2, TLR1, TNF, TRAF6, RAB7A, CALM2, CALM3, CALML3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMP, EEA1, CASP10, RFXANK, TRADD, RIPK2, FADD, KSR1, BCL10, FCGR2C, ATP6V0D1, CALML4, CD74, MRC2, MALT1, CREB1, MAPK14, CTSD, AKT1, FCGR3A, ATP6V0A2, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, APAF1, HSPA9, HSPD1, IFNA1, IFNG, IL1A, IL1B, IL6, IL10, IL12A, IL18, RHOA, NFKB1, NOS2, IL23A, CYCS, MAPK1, MAPK3, MAPK8, BAD, B |
| Type I diabetes mellitus | CPE, GAD1, GAD2, GZMB, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, ICA1, INS, LTA, PTPRN2, TNF, CD28, CD80, CD86, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, HSPD1, IFNG, FAS, IL1A, IL1B, IL2, FASLG, IL12A, PRF1, TNF |
| Type II diabetes mellitus | SOCS4, GCK, HK2, HK3, IKBKB, INS, PDX1, IRS1, PIK3CD, PIK3R1, PIK3R2, PKLR, PKM, PRKCD, PRKCE, PRKCZ, MAPK9, MAPK10, SLC2A4, ABCC8, TNF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, HKDC1, IRS4, PIK3R3, SOCS1, IRS2, SOCS2, CACNA1G, SOCS3, ADIPOQ, MTOR, HK1, INSR, PIK3CA, PIK3CB, MAPK1, MAPK3, MAPK8, TNF, HK1, PIK3CB |
| Tyrosine metabolism | ADH1A, ADH1B, ADH4, ADH5, ADH6, DBH, DCT, DDC, FAH, ALDH1A3, LRTOMT, ALDH3B1, ALDH3B2, GOT1, GOT2, GSTZ1, HGD, AOC2, AOX1, HPD, TAT, TH, TPO, TYR, TYRP1, FAHD1, AOC3, PIK3CB, RAF1, SRC, HLA-DPB1, IL4I1 |
| Ubiquinone and other terpenoid-quinone biosynthesis | COQ7, VKORC1L1, NQO1, HPD, COQ6, COQ3, TAT, VKORC1, COQ5, RAF1 |
| Ubiquitin mediated proteolysis | UBA2, SAE1, HUWE1, STUB1, UBE4B, PIAS3, UBE2E3, WWP1, WWP2, UBE2C, ERCC8, UBE2J2, UBE2QL1, UBE2F, UBE2U, DDB1, DDB2, UBOX5, TRIM32, RHOBTB2, FBXW11, MGRN1, NEDD4L, CBLC, PPIL2, CDC26, ANAPC13, RCHY1, HERC4, FBXO2, FBXW8, FBXO4, UBE2S, PRPF19, ANAPC2, ANAPC4, UBE2K, AIRE, BIRC2, XIAP, UBE2NL, MAP3K1, MID1, TRIM37, NEDD4, PRKN, FZR1, UBR5, ANAPC5, ANAPC7, ANAPC11, PIAS4, UBE2D4, PML, UBE2R2, DET1, FANCL, UBA6, UBE2W, FBXW7, UBE2Q1, KLHL9, BIRC6, RPS27A, UBE2O, COP1, ANAPC1, SMURF2, SIAH1, SKP1, SKP2, UBE2Z, ELOC, ELOB, TRAF6, UBA52, UBB, UBC, UBA7, UBE2D1, UBE2D3, UBE2E1, UBE2E2, UBE2G1, UBE2H, UBE2I, UBE2L3, UBE2N, UBE3A, VHL, BIRC7, CUL5, ITCH, SYVN1, CUL2, CUL1, PIAS1, SOCS1, CBL, CBLB, CDC23, CDC16, HERC3, HERC2, HERC1, BTRC, UBE3B, SOCS3, KLHL13, UBA3, UBE2M, PIAS2, UBE2L6, UBE2Q2, TRIP12, UBE4A, UBE3C, KEAP1, CUL7, RHOBTB1, CDC27, CDC34, RBX1, PIK3CB, LIPE, ND4, JUN, KIT, MET, MYC, NFE2L2, PIK3CA, PIK3CB, CYCS, BAX, RAF1, UBE2J1, SMURF1, UBA1, UBE2A, UBE2D2, UBE2G2, CUL4B, CUL4A, CUL3 |
| Valine, leucine and isoleucine biosynthesis | SDS, SDSL, BCAT1, BCAT2 |
| Valine, leucine and isoleucine degradation | ACAA2, ABAT, ECHS1, ACSF3, ALDH2, ALDH9A1, ALDH3A2, HIBCH, ACAD8, ACAA1, HSD17B10, HADHA, HADHB, HADH, HMGCL, HMGCS1, HMGCS2, AOX1, ACADM, ACADS, ACADSB, IVD, ALDH6A1, OXCT1, PCCA, PCCB, HMGCLL1, AUH, MCCC1, BCAT1, BCAT2, BCKDHA, BCKDHB, OXCT2, MCCC2, AACS, MCEE, JUN, MET, PIK3CA, PIK3CB, DLD, IL4I1 |
| Various types of N-glycan biosynthesis | ALG3, MAN1A2, MGAT4B, MGAT4A, MGAT4D, DAD1, DDOST, ALG14, STT3B, FUT8, MGAT4C, B4GALT1, B4GALNT3, HEXD, B4GALNT4, STT3A, MAN1A1, MAN2A2, MAN2A1, MGAT2, ALG1, MAN1C1, RPN1, RPN2, CHST8, ALG13, CHST9, ALG2, B4GALT3, B4GALT2, HLA-E, HLA-G, KIR2DL2, PIK3CA, PIK3CB, MGAT1, TUSC3 |
| Vascular smooth muscle contraction | CALCRL, RAMP2, RAMP1, RAMP3, IRAG1, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, MYL6B, ADRA1D, ADRA1B, ADRA1A, CYP4A11, CALML6, AGT, AGTR1, EDN1, EDN3, ADCY4, ARHGEF12, PLA2G2D, KCNMB3, KCNMB4, GNA11, GNA12, GNAQ, GUCY1A2, GUCY1A1, GUCY1B1, MYLK4, ITPR1, ITPR2, ITPR3, KCNMA1, KCNMB1, MYH11, MYL6, MYLK, PPP1R12A, PPP1R12B, NPPC, NPR1, NPR2, PLA2G3, CALML5, PLA2G1B, PLA2G4A, PLA2G5, PLCB2, PLCB3, PPP1R12C, PPP1CB, AVP, AVPR1B, PRKACB, PRKACG, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKG1, MAP2K1, MAP2K2, PTGIR, ACTA2, ROCK1, BRAF, CACNA1C, CACNA1D, CALCA, CALCB, CALD1, CALM2, CALM3, CALML3, PLA2G12A, PLA2G10, PLA2G12B, MYLK2, PLA2G4C, ARHGEF1, MYLK3, CALML4, PPP1R14A, ROCK2, ARHGEF11, GNA13, ADCY1, ADCY2, ADCY3, ADM, KCNU1, EDNRA, PLCB1, GNAS, RHOA, PLA2G2A, PPP1CC, PRKACA, PRKCA, MAPK1, MAPK3, RAF1, CACNA1S, CALM1, PLA2G6, GNA13, ADCY1, ADCY3, KCNU1, GNA12, RHOA, PPP1CC, PRKACA, PRKCA, CALM1 |
| Vasopressin-regulated water reabsorption | CREB3, DCTN2, DCTN6, ADCY6, ADCY9, DYNLL2, DYNC1I1, DYNC1I2, DYNC1LI2, AQP2, AQP3, ARHGDIB, ARHGDIG, NSF, DYNC1LI1, DCTN4, DYNC2LI1, AVP, AVPR2, PRKACB, PRKACG, RAB5A, RAB5B, RAB5C, CREB3L2, STX4, DCTN5, CREB3L3, RAB11A, RAB11B, CREB5, ADCY3, CREB1, CREB3L4, DYNC1H1, GNAS, AQP4, ARHGDIA, PRKACA, VAMP2, DYNC2H1, DYNLL1, ADCY3, CREB1, CREB3L4, AQP4, PRKACA, VAMP2 |
| VEGF signaling pathway | AKT3, AKT2, SHC2, HRAS, HSPB1, KRAS, NFATC2, PIK3CD, PIK3R1, PIK3R2, PLA2G4A, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB, PRKCG, MAPK11, MAPK13, MAP2K1, MAP2K2, SPHK2, PTK2, PXN, RAC1, RAC2, RAC3, MAPK12, MAPKAPK3, PIK3R3, PLA2G4C, SH2D2A, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, PIK3CA, PIK3CB, CYCS, BAX, SRC, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, MYC, PIK3CA, PIK3CB, CYCS, BAX, PIK3CB, PLCG1, PRKCA, MAPKAPK2 |
| Vibrio cholerae infection | TCIRG1, KDELR1, SEC61B, KDELR2, KDELR3, ADCY9, ATP6V1G3, ATP6V0E2, SEC61G, ATP6V1C2, SEC61A1, ERO1A, ARF1, ATP6V0A4, ATP6V1D, ATP6V1H, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V0C, ATP6V1C1, ATP6V1E1, ATP6V0B, PLCG2, ATP6V1G2, ATP6V0A1, ATP6AP1, SEC61A2, PRKACB, PRKACG, SLC12A2, TJP1, ACTG1, ATP6V0E1, ATP6V1E2, ATP6V0D1, ATP6V1F, ATP6V1G1, PDIA4, CFTR, ADCY3, ATP6V0A2, GNAS, KCNQ1, PLCG1, PRKACA, PRKCA, ACTB, TJP2, ADCY3, KCNQ1, PLCG1, PRKACA, PRKCA, TJP2 |
| Viral carcinogenesis | HDAC6, HDAC5, CDK6, CDKN1A, CDKN1B, CDKN2B, IRF9, CREB3, CHD4, CCR3, CCR4, H2BU1, ATF2, CREBBP, ATF6B, DDB1, DDX3X, DLG1, EGR2, EGR3, EP300, SNW1, UBR4, SCRIB, KAT2A, SND1, H2BW2, GRB2, GTF2A1, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2H1, GTF2H3, GTF2H4, H2BC5, H2BC3, HDAC2, HLA-F, HNRNPK, HPN, HRAS, RBPJ, IRF3, IRF7, JAK1, JAK3, KRAS, TBPL2, LTBR, LYN, ATF4, NFKB2, NFKBIA, HDAC7, PIK3CD, PIK3R1, PIK3R2, PKM, POLB, H4C15, PRKACB, PRKACG, VAC14, HDAC8, EIF2AK2, PSMC1, PXN, RAC1, RASA2, RBL1, RBL2, CCND1, REL, RELA, CREB3L2, SKP2, SP100, SRF, STAT5A, STAT5B, SYK, TP53, TRAF1, TRAF2, TRAF3, TRAF5, UBE3A, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, USP7, HDAC11, ACTN4, H2BC8, H2BC15, H2BC6, H2BC9, H2BC10, H2BC4, H2BC17, H2BC21, H4C1, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C5, H4C13, H4C7, MAD1L1, HDAC10, CREB3L3, PIK3R3, IKBKG, H2BC12, SCIN, ACTN1, TRADD, HDAC3, KAT2B, CCND3, CCNE1, ATP6V0D1, CCNE2, CREB5, HDAC9, HDAC4, CDK2, CDKN2A, YWHAQ, GTF2A1L, CHEK1, HIST4H4, CCR5, CREB1, CREB3L4, H2BFWT, HIST1H2BA, GSN, HDAC1, HLA-A, HL |
| Viral myocarditis | CXADR, CD55, DAG1, DMD, EIF4G2, ABL1, ABL2, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-F, ITGAL, ITGB2, MYH6, RAC1, RAC2, RAC3, CCND1, BID, SGCA, SGCB, SGCD, ACTG1, CAV1, CD28, CD80, CD86, CD40, EIF4G1, FYN, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-E, HLA-G, ICAM1, LAMA2, MYH7, CYCS, PRF1, ACTB, CASP3, CASP8, CASP9, CAV1, EIF4G3, EIF4G1, LAMA2, EIF4G3 |
| Viral protein interaction with cytokine and cytokine receptor | CCL26, CCL27, IL24, CCR1, CCR3, CCR4, CCR6, CCR7, CSF1R, IL34, CX3CR1, CCR10, XCR1, CXCR3, CXCL1, CXCL2, CXCL3, IL19, IL2RB, IL2RG, CXCR1, CXCR2, IL10RA, IL10RB, CXCL10, LTA, LTBR, CCL3L3, IL20, ACKR4, PF4, PF4V1, IL20RB, PPBP, CCL28, ACKR3, IL22RA1, CCL1, CCL2, CCL3, CCL7, CCL8, CCL11, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CXCL6, CXCL11, CXCL5, CXCL12, CXCR5, TNF, CXCR4, TNFSF14, TNFRSF14, TNFRSF10D, TNFRSF10C, TNFRSF10B, TNFRSF10A, IL18RAP, CXCL14, CCR5, CSF1, IL37, IL2, IL2RA, IL6, IL6R, IL6ST, CXCL8, IL10, IL18, CCL5, CX3CL1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, IL37 |
| Vitamin B6 metabolism | AOX1, PHOSPHO2, PNPO, PDXP, HLA-DRB1, JUN |
| Vitamin digestion and absorption | SLC19A2, SLC52A3, PLB1, FOLH1, MMACHC, CBLIF, APOA1, APOA4, PNLIP, RBP2, BTD, TCN2, CUBN, SLC19A3, SLC5A6, SCARB1, SLC23A1, APOB, ABCC1, SLC19A1 |
| Wnt signaling pathway | APC2, WIF1, CSNK1A1L, CREBBP, PRICKLE1, CSNK1A1, CSNK1E, CSNK2A1, NOTUM, CTBP1, CTBP2, CTNND2, PRICKLE2, DVL1, DVL2, DVL3, EP300, GPC4, DKK1, FBXW11, FRAT2, DAAM2, FZD2, CBY1, BAMBI, CACYBP, DKK4, DKK2, INVS, APC, RSPO2, PRICKLE3, LRP6, LRP5, SMAD3, SMAD4, NFATC1, NFATC2, NFATC3, NFATC4, ROR1, ROR2, LEF1, WNT16, NLK, SERPINF1, PLCB2, PLCB3, WNT4, PPARD, RNF43, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, LGR4, PRKACB, PRKACG, PRKCB, PRKCG, MAPK9, MAPK10, PSEN1, CTNNBIP1, VANGL2, CHD8, RAC1, RAC2, RAC3, SENP2, LGR6, CCND1, RYK, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, MAP3K7, TBL1X, TCF7, TP53, WNT3, WNT6, WNT7A, WNT7B, WNT8B, WNT10B, WNT11, WNT2B, WNT9A, WNT9B, FZD5, FZD3, CXXC4, WNT10A, WNT5B, CAMK2A, CAMK2B, CAMK2D, CAMK2G, VANGL1, AXIN1, AXIN2, FZD1, FZD4, FZD6, FZD7, FZD8, FZD9, TCF7L1, ZNRF3, CUL1, RSPO3, NKD1, NKD2, LGR5, RUVBL1, CCN4, BTRC, CCND3, WNT3A, CER1, ROCK2, RBX1, PIK3CA, PIK3CB, SRC, JUN, CYCS, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CYCS, BAX, RA |
| Yersinia infection | AKT3, ACTR3, ACTR2, WASF2, VAV3, TAB1, BAIAP2, NLRP3, CRK, CRKL, WIPF2, NLRP4, TICAM1, DOCK1, AKT2, PTK2B, TAB2, ARHGEF12, PIP5K1C, FOS, FYB1, LAT, PYCARD, TBK1, IKBKB, IRAK1, IRF3, ARF6, LCK, LCP2, LIMK1, MYD88, NFATC1, NFATC2, NFATC3, NFKBIA, IRAK4, PIK3CD, PIK3R1, PIK3R2, PKN1, PKN2, MAPK11, MAPK9, MAPK10, MAPK13, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP2K7, ACTR3B, PTK2, PXN, RAC1, RAC2, RAC3, RELA, ROCK1, RPS6KA1, RPS6KA2, MAPK12, CCL2, MAP2K4, ARHGEF28, ACTR3C, MAP3K7, ACTG1, TNF, TRAF2, TRAF6, VAV1, VAV2, WAS, WIPF1, ZAP70, PIP5K1A, PIP5K1B, PIK3R3, IKBKG, ARHGEF7, SKAP2, ARHGEF1, ROCK2, BCAR1, GIT2, MAPK14, TICAM1, AKT1, FN1, GSK3B, IL1B, IL2, IL6, CXCL8, IL10, IL18, ITGA4, ITGA5, ITGB1, JUN, RHOA, MEFV, NFKB1, PIK3CA, PIK3CB, PLCG1, MAPK1, MAPK3, MAPK8, ACTB, WIPF3, SRC, TLR4, TNF, CASP1, WASL, CDC42, TICAM1, RHOA, PIK3CB, PLCG1 |