• PMID: 9459087
• Gene Name: PGR
• Condition: Male infertility
• Association: Associated
• Population size: 20
• Population details: 20 (8 cases of fertile couples, 12 cases of infertile cases ( 3 with normozoospermia, 2 with oligozoospermia, 1 with asthenozoospermia, and 2 with teratozoospermia, 1 with normozoospermia, 1 with asthenozoospermia, and 2 with oligoasthenozoospermia ))
• Sex: Male
• Infertility type: Male infertility
• Associated genes: ER, PR
• Other associated phenotypes: Male infertility

Immunohistochemical detection of estrogen and progesterone receptors in spermatozoa of infertile men

Misao R, Niwa K, Morishita S, Fujimoto J, Nakanishi Y, Tamaya T.

OBJECTIVE: To evaluate the clinical implication of sex steroidal actions on human spermatozoa. PATIENTS AND METHODS: Human spermatozoa were obtained from 20 males. Immunohistochemical staining for estrogen receptors (ER) and progesterone receptors (PR) was conducted by the avidin-biotin-peroxidase complex method. RESULTS: Positive immunohistochemical staining of ER and PR was observed in all 8 cases of fertile couples. From infertile couples, ER were detected in 8/12 cases, including 3 with normozoospermia, 2 with oligozoospermia, 1 with asthenozoospermia, and 2 with teratozoospermia, but not in 4/12 cases, 1 with normozoospermia, 1 with asthenozoospermia, and 2 with oligoasthenozoospermia. PR were undetectable in all cases of negative ER and in 1 case (normozoospermial) of positive ER. CONCLUSION: Negative ER and/or PR in spermatozoa from infertile couples might be involved in cases of male infertility. FAU - Misao, R AU - Misao R AD - Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan. FAU - Niwa, K AU - Niwa K FAU - Morishita, S AU - Morishita S FAU - Fujimoto, J AU - Fujimoto J FAU - Nakanishi, Y AU - Nakanishi Y