• PMID: 9262280
• Gene Name: IL1B
• Condition: Male infertility
• Association: Associated
• Population size: 140
• Population details: 140 (21 fertile subjects, 119 patients with a range of andrological diseases)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IL-beta, IL-2, IL-6, sR IL-2, SR IL-6
• Other associated phenotypes: Male infertility

Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility

Dousset B, Hussenet F, Daudin M, Bujan L, Foliguet B, Nabet P.

Several lines of evidence indicate that cyokines are involved in male fertility. They are secreted by different parts of the male genital tract and may exert effects on steroidogenesis, spermatogenesis and sperm functions. We measured the concentrations of interleukins (IL-beta, IL-2, IL-6) and those of interleukin soluble receptors (sR IL-2, SR IL-6) in semen of fertile subjects (n = 21) and of patients with a range of andrological diseases (n = 119). The seminal concentrations of cytokines were analysed according to semen parameters as well as to the blood hormonal profiles of follicle stimulating hormone, luteinizing hormone and testosterone. An increase of IL-1beta was observed in the group of patients with infertility. No difference was found between the different subgroups defined on the basis of progressive motility, percentage of abnormal forms and diagnosis of infection. The seminal cytokine concentrations were independent of the blood hormonal status. Our data suggest that the determination of interleukins (-1beta, -2 and -6) or interleukin soluble receptors (sR IL-2, sR IL-6) in human spermatozoa does not provide convenient information in male routine infertility work-up. FAU - Dousset, B AU - Dousset B AD - Laboratoire Central de Chimie, Centre Hospitalier Universitaire, Nancy, France. FAU - Hussenet, F AU - Hussenet F FAU - Daudin, M AU - Daudin M FAU - Bujan, L AU - Bujan L FAU - Foliguet, B AU - Foliguet B