• PMID: 9163102
• Gene Name: POU5F1
• Condition: Have a regulatory role in control of meiosis and/or terminal differentiation of spermatogenic cells
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Have a regulatory role in control of meiosis and/or terminal differentiation of spermatogenic cells

[An immunohistochemical study of the expression of transcription factor Oct3/4 in mouse spermatogenesis]

Tomilin AN, Kostyleva EI, Drosdovski? MA, Seralini JE, Vorob'ev VI.

The expression of POU-domain transcription factor Oct3/4 in the testis of adult mice has been studied using indirect immunofluorescence with highly specific antibodies. The protein is shown to be expressed in germ cells of seminiferous epithelium in a stage specific manner. The protein synthesis is initiated in mid-pachytene spermatocytes, increases to reach its peak during meiotic division. The Oct3/4 level remains augmented in early spermatids, but gradually declines during their further developmental advancement. These findings imply that Oct3/4 may have a regulatory function providing for the control of meiosis and/or terminal differentiation of spermatogenic cells. FAU - Tomilin, A N AU - Tomilin AN FAU - Kostyleva, E I AU - Kostyleva EI FAU - Drosdovskiĭ, M A AU - Drosdovskiĭ MA FAU - Seralini, J E AU - Seralini JE