• PMID: 8557135
• Gene Name: GH
• Condition: Oligozoospermia, asthenozoospermic, male subfertility
• Association: Basal levels of GH were similar in all three groups and serum GH increased in all groups after arginine. However, there was a significant difference between the two patient groups and the control group characterized by an impaired GH response in the subfe
• Population size: 27
• Population details: 27 (9 oligozoospermic patients, 9 asthenozoospermic patients, 9 age- and body mass index-matched fertile males)
• Sex: Male
• Infertility type: Male infertiltiy
• Other associated phenotypes: Oligozoospermia, asthenozoospermic, male subfertility

Impaired growth hormone secretion and increased growth hormone-binding protein levels in subfertile males

Ovesen P, Jørgensen JO, Kjaer T, Ho KK, Orskov H, Christiansen JS.

OBJECTIVE: To evaluate GH secretion in subfertile males. DESIGN: Comparing GH secretion to a GH stimulation test in two different patient groups and in a control group. PATIENTS: Nine oligozoospermic patients, nine asthenozoospermic patients, and nine age- and body mass index-matched fertile males with normal spermograms. INTERVENTION: All subjects underwent an IV arginine GH stimulation test. MAIN OUTCOME MEASURES: Serum levels of FSH, LH, PRL, E2, T, insulin-like growth factor I (IGF-I), and GH-binding protein were measured. RESULTS: Basal levels of GH were similar in all three groups and serum GH increased in all groups after arginine. However, there was a significant difference between the two patient groups and the control group characterized by an impaired GH response in the subfertile patients. Serum FSH and serum GH-binding protein were significantly higher in the patient groups compared with the controls. Serum LH, PRL, T, E2, and IGF-I were similar in all three groups. CONCLUSIONS: This study demonstrates that subfertile men may suffer from relative GH insufficiency, which could have therapeutical implications. FAU - Ovesen, P AU - Ovesen P AD - Aarhus Kommunehospital, Denmark. FAU - Jørgensen, J O AU - Jørgensen JO FAU - Kjaer, T AU - Kjaer T FAU - Ho, K K AU - Ho KK FAU - Orskov, H AU - Orskov H