• PMID: 8046017
• Gene Name: IL-2R
• Condition: Low sperm motility, asthenozoospermic
• Association: Associated
• Population size: 86
• Population details: 86 (20 controls, 30 pure asthenozoospermia, 36 oligoteratoasthenozoospermia)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IL-1, IL-6, IL-2 receptors
• Other associated phenotypes: Low sperm motility, asthenozoospermic

High concentration of soluble interleukin-2 receptors in ejaculate with low sperm motility

Shimonovitz S, Barak V, Zacut D, Ever-Hadani P, Ben Chetrit A, Ron M.

The various cytokines are involved in infection and immunological reactions and thus may be involved in impairment of sperm function. The present study determined the concentrations of interleukin-1, interleukin-6 and soluble interleukin-2 receptors in ejaculates of normal donors and patients suffering from pure asthenozoospermia and patients suffering from oligoteratoasthenozoospermia. Ejaculates of patients attending the fertility clinic in Hadassah Mount Scopus Hospital, Israel, were evaluated. The patients were divided into three groups: (i) controls (n = 20), (ii) pure asthenozoospermia (n = 30), (iii) oligoteratoasthenozoospermia (n = 36). Significantly higher concentrations of soluble interleukin-2 receptors were found in the ejaculates of patients with pure asthenozoospermia 2243.1 +/- 473.6 mu/ml (mean +/- SE) as compared with controls 673.5 +/- 281.3 mu/ml (P < 0.05) and oligoteratoasthenozoospermic patients 1012.3 +/- 206.9 mu/ml (P < 0.05). Interleukin-1 and interleukin-6 concentrations were comparable in all groups studied. Our results show that human ejaculates contain interleukin-1, interleukin-6 and soluble interleukin-2 receptors. High concentrations of soluble interleukin-2 receptors in the ejaculates of asthenozoospermic patients may be related to either infectious or immunological processes. FAU - Shimonovitz, S AU - Shimonovitz S AD - Department of Obstetrics and Gynaecology, Hadassah University Hospital Mount Scopus, Jerusalem, Israel. FAU - Barak, V AU - Barak V FAU - Zacut, D AU - Zacut D FAU - Ever-Hadani, P AU - Ever-Hadani P FAU - Ben Chetrit, A AU - Ben Chetrit A