• PMID: 7835127
• Gene Name: TNF
• Condition: Endometriosis/ Sperm motility
• Association: Comparing with that of infertile women without endometriosis (n = 11) and normal fertile women (n = 7), the level of PF-TNF was significantly higher in women with endometriosis (P < 0.01), in accord with the stage of the disease. Elevation of PF-TNF in e
• Population size: 34
• Population details: 34 (16 infertile women with endometriosis, 11 infertile women without endometriosis, 7 normal fertile woman)
• Sex: Female
• Infertility type: Male infertility, Female infertility
• Other associated phenotypes: Male infertility, female infertility

[Tumor necrosis factor in peritoneal fluid of infertile women with endometriosis and its relation to sperm motility]

Liang XS, Hu LN, Wu P.

Tumor necrosis factor (TNF) of 16 infertile women with endometriosis was measured in their peritoneal fluid (PF) with double monoclonal antibody ELISA method, and its effect on sperm motility and membrane integrity was evaluated by semen analysis and hypoosmotic swelling test (HOS). Comparing with that of infertile women without endometriosis (n = 11) and normal fertile women (n = 7), the level of PF-TNF was significantly higher in women with endometriosis (P < 0.01), in accord with the stage of the disease. In the PF of these patients after incubation with the donor sperms, the percentages of forward movement, total motility and hypoosmotic swelling of the donor sperms were significantly decreased (P < 0.01), showing a negative correlation to TNF levels. These results indicate that the elevation of PF-TNF in endometriosis has detrimental effect on sperm function. FAU - Liang, X S AU - Liang XS AD - Faculty of Family Planning, Chongqing University of Medical Science. FAU - Hu, L N AU - Hu LN