• PMID: 7569956
• Gene Name: BAX
• Condition: hyperplasia
• Association: In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell d
• Sex: Male
• Infertility type: Male infertility
• Associated genes: BAX, BCL2
• Other associated phenotypes: hyperplasia

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ.

BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context. FAU - Knudson, C M AU - Knudson CM AD - Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. FAU - Tung, K S AU - Tung KS FAU - Tourtellotte, W G AU - Tourtellotte WG FAU - Brown, G A AU - Brown GA