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PMID 7039539
Gene Name MIF
Condition Fertility disorders
Association Associated
Population size 29
Population details 29 infertile men, 16 of whom were also examined towards normal seminal fluid.
Sex Male
Infertility type Male infertility
Associated genes MIF
Other associated phenotypes Fertility disorders


Inhibition and enhancement of macrophage migration in the presence of lymphocytes and seminal fluid of men with fertility disorders

Livni E, Singer R, Barnet M, Sagiv M, Landau B, Joshua H, Servadio C.

Macrophage migration inhibition factor (MIF) towards autologous seminal fluid was studied in 29 infertile men, 16 of whom were also examined towards normal seminal fluid. In 10 patients, inhibition of macrophage migration was observed in the presence of 50 microgram of protein of autologous semen sonicates. Nine patients had enhanced macrophage migration in the presence of 5 microgram protein. Macrophage enhancement was more antigen dependent than the migration inhibition. In all patients seminal abnormalities were observed, being milder in the patients whose lymphocytes enhanced macrophage migration. FAU - Livni, E AU - Livni E FAU - Singer, R AU - Singer R FAU - Barnet, M AU - Barnet M FAU - Sagiv, M AU - Sagiv M FAU - Landau, B AU - Landau B FAU - Joshua, H AU - Joshua H