• PMID: 6580856
• Gene Name: AR
• Condition: Male infertility
• Association: Associated
• Population size: 82
• Population details: 82 (17 normal male controls, 65 males with genital abnormalities)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: AR
• Other associated phenotypes: Male infertility

Correlations between fibroblast androgen receptor levels and clinical features in abnormal male sexual differentiation and infertility

Warne GL, Gyorki S, Risbridger GP, Khalid BA, Funder JW.

Androgen receptor binding of radiolabelled methyltrienolone (3H-R1881) was determined in cultured genital skin fibroblasts from 17 normal male controls and from 65 males with genital abnormalities. Analysis of the results was performed with patients grouped according to the predominant clinical features. Of 16 patients with complete male pseudohermaphroditism, 12 had androgen receptor (AR) deficiency, one had "receptor-positive" Testicular Feminization, and in three, alternative diagnoses were established (17 alpha hydroxylase deficiency; 20,22-desmolase deficiency; mixed gonadal dysgenesis). In contrast, only four of 16 patients investigated for ambiguous genitalia (phallus intermediate between male and female, perineal urethra) showed AR deficiency. Borderline or slightly low AR levels were found in each of four boys in whom the sole abnormality was micropenis. In 26 boys with penile hypospadias, however, only one had low AR. Very low levels of AR (levels comparable to those seen in complete Testicular Feminization) were found in two of three men with infertility associated with abnormally high serum testosterone levels. FAU - Warne, G L AU - Warne GL FAU - Gyorki, S AU - Gyorki S FAU - Risbridger, G P AU - Risbridger GP FAU - Khalid, B A AU - Khalid BA