• PMID: 3886437
• Gene Name: GNRH1
• Condition: Human spermatogenesis, oligozoospermia
• Association: Associated
• Population size: 103
• Population details: 103 samples were divided into four groups. In the low-concentration groups (oligozoospermic patients), the hormonal concentrations differed significantly (P less than 0.05) between those specimens demonstrating good and poor motility
• Sex: Male
• Infertility type: Male infertility
• Associated genes: LH-RH
• Other associated phenotypes: Human spermatogenesis, oligozoospermia

Immunoreactive luteinizing hormone-releasing hormone in the seminal plasma and human semen parameters

Izumi S, Makino T, Iizuka R.

A luteinizing hormone-releasing hormone (LH-RH)-like substance has been detected in human seminal plasma by a radioimmunoassay (RIA) with a highly specific anti-LH-RH antiserum. The seminal samples--not only the plasma itself but also the sample extracted by an acid/alcohol method--showed satisfactory displacement curves in our RIA system. The relationship between fertility and the LH-RH values in the seminal plasma was studied by comparing the peptide levels with sperm concentration and motility. By these two parameters, 103 samples were divided into four groups. In the low-concentration groups (oligozoospermic patients), the hormonal concentrations differed significantly (P less than 0.05) between those specimens demonstrating good and poor motility. These data suggest that this immunoreactive LH-RH may play a role in human spermatogenesis. FAU - Izumi, S AU - Izumi S FAU - Makino, T AU - Makino T