• PMID: 31332817
• Gene Name: KISS1
• Condition: Male infertility
• Association: Associated
• Mutation: (E1225K [G/A 3673], (P1945A [C/G 5833]; Insertion of T at 6075; G2026G [C/G 6078])
• Population size: 168
• Population details: 168 (88 cases, 80 controls)
• Sex: Male
• Infertility type: Male infertility

Kisspeptin and attributes of infertile males and females: A cross-sectional study in a subset of Pakistani population

Rehman R, Fatima SS, Alam F, Ashraf M, Zafar S.

Kisspeptin, a peptide hormone, plays a pivotal role in fertility and neuroendocrine regulation of hypothalamo-pituitary-gonadal axis. Increased kisspeptin and reproductive hormones are responsible for fertility in male and females. This study aimed to explore the role of kisspeptin on hypothalamo-pituitary-gonadal axis by comparing the levels of kisspeptin in fertile and infertile subjects and identifying single nucleotide polymorphisms (SNPs) of KISS1 gene in exon 2 and exon 3 of infertile male and female cohorts. A cross-sectional study was carried out on 80 males (44 infertile and 36 fertile) and 88 females (44 in each group). Significantly high levels of kisspeptin (KP), follicle-stimulating hormone (FSH), luteinizing hormone and testosterone were observed in fertile male and female subjects except low FSH levels in comparison with infertile female subjects. One polymorphism in exon 2 (E1225K [G/A 3673]) and three in exon 3 (P1945A [C/G 5833]; Insertion of T at 6075; G2026G [C/G 6078]) in infertile group were detected, with low KP and hormonal levels. Male subjects had abnormal sperm parameters and unsuccessful attempt of intracytoplasmic sperm injection in females. Expression of SNP in exon 2 and exon 3 of KISS1 could be responsible for alteration in release of reproductive hormones and gonadal functions, hence causing infertility. CI - © 2019 Blackwell Verlag GmbH. FAU - Rehman, Rehana AU - Rehman R AUID- ORCID: 0000-0001-9730-5553 AD - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. FAU - Fatima, Syeda S AU - Fatima SS AUID- ORCID: 0000-0002-3164-0225 AD - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. FAU - Alam, Faiza AU - Alam F AUID- ORCID: 0000-0002-4131-129X AD - Department of Physiology, University of Karachi, Karachi, Pakistan. FAU - Ashraf, Mussarat AU - Ashraf M AD - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.