• PMID: 3084303
• Gene Name: TF
• Condition: Seminiferous tubular dysfunction
• Association: Not Associated
• Population size: 158
• Population details: 158 normospermic, oligospermic, and azoospermic men
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Transferrin
• Other associated phenotypes: Seminiferous tubular dysfunction

Seminal plasma transferrin and seminiferous tubular dysfunction

Chan SY, Loh TT, Wang C, Tang LC.

Seminal plasma transferrin levels were assayed in 158 random semen samples collected from normospermic, oligospermic, and azoospermic men, and their relationships with seminal characteristics, sperm fertilizing capacity as assessed by the zona-free hamster ova penetration assay, and serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were evaluated. The concentrations of seminal plasma transferrin in azoospermic, oligospermic and postvasectomy samples were significantly lower than those in normospermic samples. Seminal plasma transferrin concentrations were similar in azoospermia due to obstruction of the reproductive tract or damage to the germinal epithelium. No significant difference in seminal plasma transferrin concentrations was observed in the groups of subjects with normal and elevated FSH or normal and elevated LH. A positive correlation was observed between seminal plasma transferrin concentration and sperm density and between total semen transferrin content and the total number of sperm in the ejaculate. There were no significant correlations between seminal plasma transferrin concentration and sperm motility, percent normal sperm, sperm fertilizing capacity, and serum FSH or LH concentration. The results indicate that seminal plasma transferrin is not a useful marker for Sertoli cell or seminiferous tubular dysfunction. In addition, it is doubtful that measurement of seminal plasma transferrin will yield additional information regarding the fertility potential of semen samples. FAU - Chan, S Y AU - Chan SY FAU - Loh, T T AU - Loh TT FAU - Wang, C AU - Wang C