• PMID: 30155914
• Gene Name: TP53
• Condition: Male infertility
• Association: Associated
• Mutation: Arg72Pro
• Population size: 4096
• Population details: 4096 (1,818 cases, 2,278 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

TP53 gene Arg72Pro polymorphism and male infertility risk: A meta-analysis

Ren ZJ, Zhang Q, Ren PW, Yang B, Liu SZ, Liao J, Yang LC, Lu DL, Liu LR, Dong Q.

To evaluate the association between TP53 codon72 polymorphism and male infertility risk. We conducted a search on Medline, Embase, Web of Science and CNKI up to April 30, 2017. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the association. Seven studies including 1,818 cases and 2,278 controls met the inclusion criteria. The pooled results indicated that no significant association was observed between TP53 codon72 polymorphism and male infertility risk (G versus C: OR = 1.11, 95%CI = 0.94-1.32; GG versus CC: OR = 1.26, 95%CI = 0.90-1.78; GG versus GC+CC: OR = 1.16, 95%CI = 0.90-1.49; GG+GC versus CC: OR = 1.15, 95%CI = 0.88-1.49). In the subgroup analysis by ethnicity, significant association was observed between TP53 codon72 polymorphism and male infertility risk in non-Chinese (G versus C: OR = 1.47, 95%CI = 1.14-1.89), but not in Chinese population (G versus C: OR = 1.03, 95%CI = 0.87-1.22). In conclusion, this study suggested that TP53 codon72 polymorphism might be associated with an increased susceptibility to male infertility in non-Chinese population, but not in Chinese population. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results. CI - © 2018 Blackwell Verlag GmbH. FAU - Ren, Zheng-Ju AU - Ren ZJ AUID- ORCID: 0000-0003-1897-6215 AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Qin AU - Zhang Q AD - Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China. FAU - Ren, Peng-Wei AU - Ren PW AD - Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China. FAU - Yang, Bo AU - Yang B AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Liu, Sheng-Zhuo AU - Liu SZ AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Liao, Jian AU - Liao J AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Yang, Lu-Cheng AU - Yang LC AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Lu, Dong-Liang AU - Lu DL AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Liu, Liang-Ren AU - Liu LR AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.