• PMID: 29738186
• Gene Name: FSHR
• Condition: Male infertility
• Association: Associated
• Mutation: Thr307Ala, Asn680Ser
• Population size: 6205
• Population details: 6205 (2 893 male infertility patients, 3 312 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis]

Luo J, Wang L, Shi HC, Zeng QQ, Wu QY, Li WW.

OBJECTIVE: To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility. METHODS: We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software. RESULTS: A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI: 1.03－1.54, P = 0.023), 1.18 (95% CI: 1.03－1.36, P = 0.018), and 1.20 (95% CI: 1.05－1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI: 1.05－1.45, P = 0.009) and 1.20 (95% CI: 1.04－1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI: 1.03－1.82, P = 0.003) and 1.21 (95% CI: 1.00－1.47, P = 0.048), respectively. CONCLUSIONS: In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility. FAU - Luo, Jun AU - Luo J AD - Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China. AD - Department of Clinical Laboratory, Jiangsu Provincial Agency Hospital, Nanjing, Jiangsu 210002, China. FAU - Wang, Lin AU - Wang L AD - Department of Clinical Laboratory, The Second Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210002, China. FAU - Shi, Heng-Chuan AU - Shi HC AD - Department of Clinical Laboratory, Jiangsu Provincial Agency Hospital, Nanjing, Jiangsu 210002, China. FAU - Zeng, Qing-Qi AU - Zeng QQ AD - Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China. FAU - Wu, Qiu-Yue AU - Wu QY AD - PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.