• PMID: 29459487
• Gene Name: PNLDC1
• Condition: Maturation during mouse spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Maturation during mouse spermatogenesis

Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis

Bronkhorst AW, Ketting RF.

Transposon silencing within the germ line requires the proper processing of piRNA intermediates. However, the enzyme that is required for piRNA 3′ end maturation in vertebrates remained enigmatic. Nishimura et al 1 in this issue of EMBO Reports and two independent studies 2, 3 now identified PNLDC1 as the exonuclease that is responsible for piRNA 3′ end processing and transposon silencing during mouse spermatogenesis. Together, these studies establish PNLDC1 as the piRNA 3′ end trimmer in mouse. FAU - Bronkhorst, Alfred W AU - Bronkhorst AW AD - Institute of Molecular Biology, Biology of non-coding RNA, Mainz, Germany.