• PMID: 29376593
• Gene Name: GSTT1
• Condition: Male infertility
• Association: Associated
• Population size: 264
• Population details: 264 (160 infertile Russian men of reproductive age, 104 healthy Russian volunteers)
• Sex: Male
• Infertility type: Male infertility

[Association of polymorphism of GSTT1 and GSTM1 genes with infertility in men]

Kurashova NA, Belyaeva EV, Ershova OA, Dashiev BG, Bairova TA, Kolesnikova LI.

AIM: To identify the association between homozygous deletion genotypes of glutathione transferase genes GSTT1 (glutathione transferase theta 1), GSTM1 (glutathione S-transferase mu1) and infertility in Russian men. MATERIALS AND METHODS: The article presents a comparative analysis of the incidence of homozygous deletion genotypes of glutathione transferase genes GSTM1 and GSTT1 in Russian men with and without infertility. The study group comprised 160 infertile Russian men of reproductive age (mean age 30.2+/-3.6 years.) The infertility diagnosis was verified according to the WHO guidelines. The control group comprised 104 healthy Russian volunteers (mean age 31.3+/-5.4 years.) Molecular genetic detection of GSTM1 and GSTT1 deletion polymorphisms was performed using PCR. The genomic DNA for the study was extracted from whole blood samples. RESULTS: The study and control group differed significantly in incidence of GSTM1 (p=0.043) and GSTT1 (p=0.008) deletion polymorphisms. The probability of detecting "zero" genotypes of the GSTT1 and GSTM1 genes in infertile men was 2.5 (p<0.05) and 1.7 times higher (p<0.05), respectively, than in fertile men. CONCLUSIONS: Therefore, the study findings allow us to conclude that the deletion genotypes of GSTM1 and GSTT1 are associated with infertility in Russian men. Molecular genetic analysis of deletion polymorphism of glutathione transferase genes can be recommended for a comprehensive examination of infertile men. FAU - Kurashova, N A AU - Kurashova NA AD - Research Center for Family Health and Human Reproduction, Irkutsk, Russia. AD - Republican Perinatal Center of Minzdrav of BR, Ulan-Ude, Russia. FAU - Belyaeva, E V AU - Belyaeva EV AD - Research Center for Family Health and Human Reproduction, Irkutsk, Russia. AD - Republican Perinatal Center of Minzdrav of BR, Ulan-Ude, Russia. FAU - Ershova, O A AU - Ershova OA AD - Research Center for Family Health and Human Reproduction, Irkutsk, Russia. AD - Republican Perinatal Center of Minzdrav of BR, Ulan-Ude, Russia. FAU - Dashiev, B G AU - Dashiev BG AD - Research Center for Family Health and Human Reproduction, Irkutsk, Russia. AD - Republican Perinatal Center of Minzdrav of BR, Ulan-Ude, Russia. FAU - Bairova, T A AU - Bairova TA AD - Research Center for Family Health and Human Reproduction, Irkutsk, Russia. AD - Republican Perinatal Center of Minzdrav of BR, Ulan-Ude, Russia.