• PMID: 28942044
• Gene Name: FASLG
• Condition: Idiopathic azoospermia, Male infertility
• Association: Associated
• Mutation: FAS-670A/G and FASL-844C/T polymorphisms
• Population size: 212
• Population details: 212 (102 infertile men, 110 normal fertile men as control group)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic azoospermia, Male infertility

Association of FAS-670A/G and FASL-844C/T polymorphisms with idiopathic azoospermia in Western Iran

Asgari R, Mansouri K, Bakhtiari M, Bidmeshkipour A, Yari K, Shaveisi-Zadeh F, Vaisi-Raygani A.

OBJECTIVE: The FAS/FASL interaction plays a central role in up-regulation of apoptosis in testis. Studies indicated that the FAS-670A/G and FASL-844C/T polymorphisms are associated with the risk of idiopathic azoospermia in different ethnic groups. Therefore, the current study aims to investigate the association between FAS-670A/G and FASL-844C/T polymorphisms with male idiopathic infertility in Western Iran. STUDY DESIGN: The analysis of FAS-670A/G and FASL-844C/T polymorphisms were carried out using the PCR-RFLP approach, on 102 infertile men and 110 normal fertile men as control group. RESULTS: The results suggested that there were no significant difference in genotypic frequencies of FAS-670A/G polymorphism between infertile and control groups. On the other hand, significant result was observed for the frequency of FASL-844C/T polymorphism in infertile men in comparison to control group (P=0.02). Indeed, men with FASL-844TT and CT genotypes had an increased risk of idiopathic azoospermia in comparison to those with CC genotype (OR=2.02, 95% CI [1.05-3.88, P=0.03] and OR=1.44, 95% CI [0.46-4.49, P=0.53]), respectively. CONCLUSION: Our findings speculate that the FASL-844C/T polymorphism is associated with the risk of male infertility and this variation can be considered as a genetic risk factor for idiopathic azoospermia among Western Iranian men population. Summing up, these data indicated that the genetic variations in FAS/FASL system have a critical role in spermatogenesis defects and subsequent male infertility. CI - Copyright © 2017 Elsevier B.V. All rights reserved. FAU - Asgari, Rezvan AU - Asgari R AD - Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran. FAU - Mansouri, Kamran AU - Mansouri K AD - Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Bakhtiari, Mitra AU - Bakhtiari M AD - Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Anatomical Sciences & Cell Biology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: mbakhtiari@kums.ac.ir. FAU - Bidmeshkipour, Ali AU - Bidmeshkipour A AD - Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran. FAU - Yari, Kheirollah AU - Yari K AD - Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Shaveisi-Zadeh, Farhad AU - Shaveisi-Zadeh F AD - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.