• PMID: 28436330
• Gene Name: MTRR
• Condition: Oligoasthenozoospermia, Male infertility
• Association: Associated
• Mutation: MTRR 66A>G
• Population size: 2801
• Population details: 2801 (1438 patients, 1363 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligoasthenozoospermia, Male infertility

Association between Methionine Synthase Reductase A66G Polymorphism and Male Infertility: A Meta-Analysis

Xu W, Zhang L, Wu X, Jin F.

The aim of this meta-analysis was to assess the methionine synthase reductase (MTRR) gene 66A>G polymorphism and male infertility susceptibility. Studies were identified in PubMed and Embase databases. An odds ratio (OR) was used to assess the relationship between MTRR 66A>G polymorphism and male infertility risk. A total of seven case-control studies containing 1438 patients and 1363 controls were enrolled in the meta-analysis. Our results showed that no association exists between the MTRR 66A>G polymorphism and male infertility risk in the total population (GG vs. AA: OR = 1.29, 95% confidence interval [CI] = 1.00-1.66; GA vs. AA: OR = 1.09, 95% CI = 0.92-1.30; dominant model: OR = 1.13, 95% CI = 0.96-1.34; recessive model: OR = 0.83, 95% CI = 0.67-1.03). In a subgroup analysis by nationality, the 66A>G polymorphism was not associated with male infertility in both Asians and Caucasians. In a subgroup analysis stratified by male infertility type, significant association was found with oligoasthenozoospermia (OAT) (GG vs. AA: OR = 1.83, 95% CI = 1.24-269; GA vs. AA: OR = 1.36, 95% CI = 0.88-2.11; dominant model: OR = 1.51, 95% CI = 1.13-2.01; recessive model: OR = 0.62, 95% CI = 0.46-0.85). In summary, the present meta-analysis suggests that MTRR 66A>G polymorphism may be associated with OAT risk. FAU - Xu, Weihai AU - Xu W AD - Department of Reproductive and Genetics, Women's Hospital, Zhejiang University, Hangzhou, Zhejiang, 310006, China. FAU - Zhang, Lin AU - Zhang L AD - Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, China. FAU - Wu, Xiangli AU - Wu X AD - Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, China.