• PMID: 28161861
• Gene Name: AHR
• Condition: Oligoasthenoteratozoospermia, Male infertility
• Association: Associated
• Mutation: rs2066853
• Population size: 170
• Population details: 170 (50 normozoospermia, 120 oligoasthenoteratozoospermia (OAT))
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligoasthenoteratozoospermia, Male infertility

Aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism association with infertile oligoasthenoteratozoospermic men and seminal oxidative stress

Mostafa T, Fouad H, Nabil N, Rashed L, Sabry D, Abougabal K, Gendy BS.

This study aimed to assess the association between aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism with infertile oligoasthenoteratozoospermic (OAT) men and seminal oxidative stress (OS). A total of 170 Egyptian men were allocated according to their semen analysis into fertile normozoospermic controls (n = 50) and infertile OAT men (n = 120). They were subjected to history taking, clinical examination, semen analysis, estimation of seminal glutathione peroxidase (GPx), and malondialdehyde (MDA). AhR rs2066853 gene polymorphism was identified in the blood by PCR-RFLP. Comparing infertile OAT men with fertile controls, AhR rs2066853 genotypes showed decreased prevalence for wild homozygous genotype GG (35.8 vs 56%) and for heterozygous genotype GA (17.5 vs 30%) and an increased prevalence for homozygous genotype AA (46.7 vs 14%). Distribution of alleles of AhR rs2066853 among OAT men compared with fertile men showed decreased prevalence of G allele (44.6 vs 71%) and an increased prevalence of A allele (55.4 vs 29%). Seminal MDA demonstrated significant increase whereas seminal GPx demonstrated significant decrease in cases with AA and GA/AA genotypes compared to cases with GG genotype. It is concluded that there is a significant association between AhR rs2066853 genotype polymorphism with decreased sperm parameters as well as increased seminal oxidative stress in infertile OAT men. FAU - Mostafa, Taymour AU - Mostafa T AD - Department of Andrology, Sexology& STIs, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt. taymour1155@link.net. FAU - Fouad, Hanan AU - Fouad H AD - Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Nabil, Nashaat AU - Nabil N AD - Department of Andrology, Sexology& STIs, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt. FAU - Rashed, Laila AU - Rashed L AD - Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Sabry, Dina AU - Sabry D AD - Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Abougabal, Khadiga AU - Abougabal K AD - Department of Clinical Pathology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.