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PMID 28099840
Gene Name H3-4
Condition Essential for entry into spermatogenesis, Male infertility
Association Associated
Sex Male
Infertility type Male infertility
Other associated phenotypes Essential for entry into spermatogenesis, Male infertility


Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.

Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia because of the loss of haploid germ cells. When differentiating spermatogonia emerge in normal spermatogenesis, H3t appears and replaces the canonical H3 proteins. Structural and biochemical analyses reveal that H3t-containing nucleosomes are more flexible than the canonical nucleosomes. Thus, by incorporating H3t into the genome during spermatogonial differentiation, male germ cells are able to enter meiosis and beyond. CI - Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ueda, Jun AU - Ueda J AD - Center for Education in Laboratory Animal Research, Chubu University, Kasugai, Aichi 487-8501, Japan; Center for Genetic Analysis of Biological Responses, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan. Electronic address: junueda@isc.chubu.ac.jp. FAU - Harada, Akihito AU - Harada A AD - Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. FAU - Urahama, Takashi AU - Urahama T AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Machida, Shinichi AU - Machida S AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Maehara, Kazumitsu AU - Maehara K AD - Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. FAU - Hada, Masashi AU - Hada M AD - Laboratory of Pathology and Development, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan. FAU - Makino, Yoshinori AU - Makino Y AD - Laboratory of Pathology and Development, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan. FAU - Nogami, Jumpei AU - Nogami J AD - Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. FAU - Horikoshi, Naoki AU - Horikoshi N AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Osakabe, Akihisa AU - Osakabe A AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Taguchi, Hiroyuki AU - Taguchi H AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Tanaka, Hiroki AU - Tanaka H AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Tachiwana, Hiroaki AU - Tachiwana H AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan. FAU - Yao, Tatsuma AU - Yao T AD - Research and Development Center, Fuso Pharmaceutical Industries, Ltd., Osaka 536-8523, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Wakayama 649-6493, Japan. FAU - Yamada, Minami AU - Yamada M AD - Center for Education in Laboratory Animal Research, Chubu University, Kasugai, Aichi 487-8501, Japan. FAU - Iwamoto, Takashi AU - Iwamoto T AD - Center for Education in Laboratory Animal Research, Chubu University, Kasugai, Aichi 487-8501, Japan. FAU - Isotani, Ayako AU - Isotani A AD - Center for Genetic Analysis of Biological Responses, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan. FAU - Ikawa, Masahito AU - Ikawa M AD - Center for Genetic Analysis of Biological Responses, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan. FAU - Tachibana, Taro AU - Tachibana T AD - Department of Bioengineering, Graduate School of Engineering, Osaka City University, Osaka 558-8585, Japan. FAU - Okada, Yuki AU - Okada Y AD - Laboratory of Pathology and Development, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan. FAU - Kimura, Hiroshi AU - Kimura H AD - Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. FAU - Ohkawa, Yasuyuki AU - Ohkawa Y AD - Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. FAU - Kurumizaka, Hitoshi AU - Kurumizaka H AD - Laboratory of Structural Biology, Graduate School of Advanced Science & Engineering, Waseda University, Tokyo 162-8480, Japan.