• PMID: 27525684
• Gene Name: TP73
• Condition: Male infertility with severe spermatogenesis
• Association: Associated
• Mutation: G4C14-to-A4T14
• Population size: 553
• Population details: 553 (301 infertile patients with severe spermatogenesis impairment (including azoospermia and severe oligospermia), 252 fertile men)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility with severe spermatogenesis

The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population

Xie T, Yu CH, Zheng Y, A ZC.

OBJECTIVE: The aim of this study was to explore the association between the polymorphism G4C14-to-A4T14 in the p73 gene and male infertility with severe spermatogenesis impairment in Chinese population. STUDY DESIGN: Three hundreds and one infertile patients with severe spermatogenesis impairment (including azoospermia and severe oligospermia) and 252 fertile men were recruited in this study. The polymorphism G4C14-to-A4T14 in the p73 gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism assay. The differences in allelic and genotypic frequencies between patients and controls were evaluated by chi-square test. RESULTS: The frequency of allele AT (28.9% vs. 22.4%, P=0.017, OR=1.41, 95% CI=1.07-1.85) in patients with severe spermatogenesis impairment was significantly higher than that in controls, whereas the genotype GC/GC was significantly decreased in patients compared with controls (48.5% vs. 59.1%, P=0.048, OR=0.65, 95% CI=0.46-0.91). CONCULUSION: The findings of this study suggested that the polymorphism G4C14-to-A4T14 in p73 gene might be associated with severe spermatogenesis impairment and could affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population. CI - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Xie, Ting AU - Xie T AD - College of Basic Medicine, Dali University, Dali, 671000, China. FAU - Yu, Cheng-He AU - Yu CH AD - College of Basic Medicine, Dali University, Dali, 671000, China; Department of Reproductive Medicine, Affiliated Hospital of Dali University, Dali, 671000, China. FAU - Zheng, Ye AU - Zheng Y AD - Department of Genetics, College of Agriculture and Biology, Dali University, Dali, 671003, China.