• PMID: 27416666
• Gene Name: CYP1A1
• Condition: Male infertility
• Association: The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.
• Mutation: CYP1A1 (rs4646422)
• Population size: 1078
• Population details: 1078 (636 infertile males, 442 normal healthy men)
• Age: Patients (21-49 years), controls (23-47 years)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population]

Zhou Q, Zhu PR, Zhang MC, Zhang J, Jiang WJ, Ni MX, Liu SM, Wu QY, Li WW, Xu HQ, Xia XY.

OBJECTIVE: To determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population. METHODS: Using the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software. RESULTS: Compared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G. CONCLUSION: The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population. FAU - Zhou, Qing AU - Zhou Q FAU - Zhu, Pei-ran AU - Zhu PR FAU - Zhang, Ming-chao AU - Zhang MC FAU - Zhang, Jing AU - Zhang J FAU - Jiang, Wei-jun AU - Jiang WJ FAU - Ni, Meng-xia AU - Ni MX FAU - Liu, Shuai-mei AU - Liu SM FAU - Wu, Qiu-yue AU - Wu QY FAU - Li, Wei-wei AU - Li WW FAU - Xu, Hao-qin AU - Xu HQ