• PMID: 27373555
• Gene Name: NOS3
• Condition: Male infertility
• Association: Associated
• Population size: 3507
• Population details: 3507 (1,968 cases, 1,539 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis

Chang J, Pan F, Tang Q, Wu W, Chen M, Lu C, Ding H, Hu L, Chen D, Xia Y, Wang X.

The association between polymorphism of eNOS and male infertility in several studies was controversial. To explore a more precise estimation of the association, a meta-analysis of eight case-control studies, including 1,968 cases and 1,539 controls, were selected. The meta-analysis was conducted by calculating the pooled odds ratio (OR) with a 95% confidence interval (95% CI). Overall, the association between T786C and risk of male infertility was obvious (TC vs. TT: OR, 1.20; 95% CI, 1.01-1.42; CC vs. TT: OR, 3.37; 95% CI, 1.65-6.87; TC/CC vs. TT: OR, 1.47; 95% CI, 1.25-1.73; CC vs. TT/TC: OR, 3.18; 95% CI, 1.54-6.56; TC vs. TT: OR, 1.65; 95% CI, 1.27-2.03). However, no overall association was observed between the other two polymorphisms of eNOS (G894T and 4a4b) and male infertility. Stratified analysis showed that significantly strong association between T786C polymorphism and semen quality was present in all three types of male infertility (azoospermia, oligozoospermia and asthenozoospermia). In the subgroup analysis based on ethnicity, both T786C and 4a4b could influence the risk of male infertility in Asian and Caucasian. Further studies of polymorphisms of eNOS with their biological functions are needed to understand the role in the development of male infertility. CI - © 2016 Blackwell Verlag GmbH. FAU - Chang, J AU - Chang J AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Pan, F AU - Pan F AD - State Key Laboratory of Reproductive Medicine, Department of Andrology, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China. FAU - Tang, Q AU - Tang Q AD - State Key Laboratory of Reproductive Medicine, Department of Obstetrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China. FAU - Wu, W AU - Wu W AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China. FAU - Chen, M AU - Chen M AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Lu, C AU - Lu C AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Ding, H AU - Ding H AD - State Key Laboratory of Reproductive Medicine, Department of Obstetrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China. FAU - Hu, L AU - Hu L AD - Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China. FAU - Chen, D AU - Chen D AD - Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China. FAU - Xia, Y AU - Xia Y AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.