• PMID: 27210772
• Gene Name: HRG
• Condition: Male infertility
• Association: Male homozygous HRG 633T SNP carriers had overall lower total sperm count, sperm concentration, motility score and yield after preparation. In conclusion, once infertility is established the HRG C633T SNP seems to be important for male infertility and pre
• Mutation: C633T
• Population size: 335
• Population details: 335 (139 infertile couples, controls were 196 pregnant couples)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

The effect of a specific histidine-rich glycoprotein polymorphism on male infertility and semen parameters

Lindgren KE, Nordqvist S, Kårehed K, Sundström-Poromaa I, Åkerud H.

In women, there is evidence that a single nucleotide polymorphism (SNP) in the histidine-rich glycoprotein (HRG) named HRG C633T is relevant for a number of fertility outcomes including recurrent miscarriage, ovarian response and pregnancy outcome after IVF. This case-control study was designed to investigate whether the HRG C633T SNP is important for male infertility and pregnancy rate following IVF. Cases were 139 infertile couples and controls were 196 pregnant couples. The 335 couples all contributed with one blood sample per partner. Genomic DNA was extracted and genotyping was performed using a TaqMan® SNP Genotyping Assay. Information on pregnancy rate and semen parameters was derived from medical records. Infertile couples in which the male partner was a homozygous carrier of the HRG C633T SNP had significantly lower (P < 0.01) pregnancy rate following IVF in comparison with couples where the male partner was a heterozygous HRG C633T SNP carrier. Male homozygous HRG 633T SNP carriers had overall lower total sperm count, sperm concentration, motility score and yield after preparation. In conclusion, once infertility is established the HRG C633T SNP seems to be important for male infertility and pregnancy rate following IVF. CI - Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lindgren, Karin E AU - Lindgren KE AD - Department of Women's and Children's Health, Uppsala University, SE-751 85 Uppsala, Sweden. Electronic address: karin.lindgren@kbh.uu.se. FAU - Nordqvist, Sarah AU - Nordqvist S AD - Department of Women's and Children's Health, Uppsala University, SE-751 85 Uppsala, Sweden; Fertilitetscentrum, Storängsvägen 10, SE-11542 Stockholm, Sweden. FAU - Kårehed, Karin AU - Kårehed K AD - Department of Women's and Children's Health, Uppsala University, SE-751 85 Uppsala, Sweden. FAU - Sundström-Poromaa, Inger AU - Sundström-Poromaa I AD - Department of Women's and Children's Health, Uppsala University, SE-751 85 Uppsala, Sweden.