• PMID: 27162065
• Gene Name: AMHR2
• Condition: Undescended testis
• Association: The AMHRII -482 A>G, AMHRII IVS 10+77 A>G, AMHRII IVS 5-6 C>T and AMH Ile49Ser genotypes should be determined in a much larger group of boys with cryptorchidism.
• Population size: 163
• Population details: 163 (105 patients with cryptorchidism, 58 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Undescended testis

Are anti-Müllerian hormone and its receptor polymorphism associated with the hormonal condition of undescended testes?

Komarowska MD, Milewski R, Charkiewicz R, Matuszczak E, Sulewska A, Zelazowska-Rutkowska B, Hermanowicz J, Niklinski J, Debek W, Hermanowicz A.

PURPOSE: Numerous genetic and endocrine factors are involved in the process of testicular descent, but only a few genetic causes have been reported in human. The aim of this study was to investigate the density and distribution of single nucleotide polymorphisms (SNPs) anti-Müllerian hormone (AMH) and AMHRII receptors in cryptorchid patients and determine potential hormone imbalance connected with undescended testes by assessing the levels of AMH, Insulin-like factor 3 (INSL3) and inhibin B. MATERIALS AND METHODS: The serum hormone levels (AMH, INSL3 and inhibin B) were compared in the two groups - cryptorchidism (n=105) and control group (n=58). The frequency of AMHRII -482 A>G, AMHRII IVS 10+77 A>G, AMHRII IVS 5-6 C>T, and AMH Ile49Ser polymorphisms among cryptorchid boys were compared with the control group. RESULTS: None of the hormones levels were different between the cryptorchid and the control groups. All cases of IVS 5-6 C>T homozygote and heterozygote mutation were accompanied by an IVS 10+77 A>G and 482 A>G homozygote and heterozygote mutation. Interestingly, in most cases of all four polymorphisms, homozygote recessive genotype was associated with cases of cryptorchidism. However, the groups of patients were too small to draw definite conclusions. CONCLUSION: The AMHRII -482 A>G, AMHRII IVS 10+77 A>G, AMHRII IVS 5-6 C>T and AMH Ile49Ser genotypes should be determined in a much larger group of boys with cryptorchidism. CI - Copyright © 2016 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. FAU - Komarowska, Marta Diana AU - Komarowska MD AD - Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, Poland. FAU - Milewski, Robert AU - Milewski R AD - Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland. FAU - Charkiewicz, Radosław AU - Charkiewicz R AD - Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland. FAU - Matuszczak, Ewa AU - Matuszczak E AD - Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, Poland. FAU - Sulewska, Anetta AU - Sulewska A AD - Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland. FAU - Zelazowska-Rutkowska, Beata AU - Zelazowska-Rutkowska B AD - Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland. FAU - Hermanowicz, Justyna AU - Hermanowicz J AD - Department of Clinical Pharmacy and Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland. FAU - Niklinski, Jacek AU - Niklinski J AD - Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland. FAU - Debek, Wojciech AU - Debek W AD - Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, Poland.