• PMID: 26940145
• Gene Name: UBR2
• Condition: Idiopathic aspermia or oligospermia, Male infertility
• Association: Associated
• Mutation: rs16895863, rs373341, rs3749897
• Population size: 465
• Population details: 465 ( 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic aspermia or oligospermia, Male infertility

Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China

Ma TJ, Zhang XJ, Ding XP, Chen HH, Zhang YW, Ding M.

The associations between three single nucleotide polymorphisms (SNPs; rs3749897, rs16895863 and rs373341) of UBR2 gene and idiopathic aspermia or oligospermia were investigated in this study by a case-control experiment with 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia. The time-of-flight mass spectrometry (Sequenom MassARRAY(®)  system) was used in this study. A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China. CI - © 2016 Blackwell Verlag GmbH. FAU - Ma, T-J AU - Ma TJ AD - Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China. AD - Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China. AD - Biotechnology Academy of Nanchuan, Chongqing, China. FAU - Zhang, X-J AU - Zhang XJ AD - Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China. FAU - Ding, X-P AU - Ding XP AD - Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China. AD - Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China. AD - Biotechnology Academy of Nanchuan, Chongqing, China. FAU - Chen, H-H AU - Chen HH AD - Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China. AD - Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China. AD - Biotechnology Academy of Nanchuan, Chongqing, China. FAU - Zhang, Y-W AU - Zhang YW AD - Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Science, Institute of Medical Genetics, Sichuan University, Chengdu, China. AD - Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chengdu, China. AD - Biotechnology Academy of Nanchuan, Chongqing, China.