• PMID: 26888488
• Gene Name: ADAMTS5
• Condition: Male infertility
• Association: In conclusion, ADAMTS1 and ADAMTS5 protein expressions in semen are significantly related with sperm production. It is very important to understand molecular function and organisation of ADAMTSs which will be significant in enlightening the process of spe
• Population size: 70
• Population details: 70 (60 infertile (20 normozoospermia, 20 oligozoopsermia, 20 ADAMTS5), 10 healthy semen donors)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: ADAMTS1, ADAMTS5
• Other associated phenotypes: Male infertility

Role of ADAMTS1 and ADAMTS5 in male infertility

Aydos SE, Yukselten Y, Sunguroglu A, Demircan K, Aydos K.

The aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases. ECM is the noncellular component that provides structural and biochemical support to the surrounding cells required for tissue morphogenesis, differentiation and homoeostasis. Sixty infertile individuals and 10 healthy semen donors were included in this study. The infertile individuals were classified as normozoospermia (NS; n = 20), oligozoospermia (OS; n = 20), azoospermia (AS; n = 20) groups. ADAMTS1 and ADAMTS5 protein levels in semen were analysed by Western blot. ADAMTS1 protein level was 3.0-, 3.3- and 1.6-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). ADAMTS5 protein level was 3.2-, 2.7- and 1.4-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). Sperm count and sperm motility showed a negative correlation with the levels of ADAMTS1 and ADAMTS5 protein expression: r = -0.477, r = -0.470; and r = -0.332, r = -0.275 respectively (P < 0.001). In conclusion, ADAMTS1 and ADAMTS5 protein expressions in semen are significantly related with sperm production. It is very important to understand molecular function and organisation of ADAMTSs which will be significant in enlightening the process of spermatogenesis in male infertility. CI - © 2016 Blackwell Verlag GmbH. FAU - Aydos, S E AU - Aydos SE AD - Department of Medical Biology, School of Medicine, Ankara University, Ankara, Turkey. FAU - Yukselten, Y AU - Yukselten Y AD - Department of Medical Biology, School of Medicine, Ankara University, Ankara, Turkey. FAU - Sunguroglu, A AU - Sunguroglu A AD - Department of Medical Biology, School of Medicine, Ankara University, Ankara, Turkey. FAU - Demircan, K AU - Demircan K AD - Department of Medical Biology, School of Medicine, Turgut Ozal University, Ankara, Turkey.