• PMID: 26472740
• Gene Name: PRM1
• Condition: Male infertility
• Association: Associated
• Mutation: rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923
• Population size: 13517
• Population details: 13517 (7350 cases, 6167 controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: protamine 1, protamine 2
• Other associated phenotypes: Male infertility

Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis

Jiang W, Sun H, Zhang J, Zhou Q, Wu Q, Li T, Zhang C, Li W, Zhang M, Xia X.

Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C > A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed. FAU - Jiang, Weijun AU - Jiang W AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Sun, Hui AU - Sun H AD - Department of Diagnostic Ultrasound, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Zhang, Jing AU - Zhang J AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Zhou, Qing AU - Zhou Q AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Wu, Qiuyue AU - Wu Q AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Li, Tianfu AU - Li T AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Zhang, Cui AU - Zhang C AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Li, Weiwei AU - Li W AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China. FAU - Zhang, Mingchao AU - Zhang M AD - Department of Reproduction and Genetics, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China.