• PMID: 26354096
• Gene Name: CatSper1
• Condition: Idiopathic asthenospermia
• Association: Associated
• Mutation: rs1893316 in CATSPER1
• Population size: 480
• Population details: 480 (192 patients with idiopathic asthenospermia, 288 healthy controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic asthenospermia

Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia

Shu F, Zhou X, Li F, Lu D, Lei B, Li Q, Yang Y, Yang X, Shi R, Mao X.

PURPOSE: Idiopathic asthenospermia is the most common type of male infertility. Although the mechanisms causing asthenospermia are complex, recent studies have indicated an important role of cation channel of sperm (CATSPER) gene downregulation or abnormality in the etiology of idiopathic asthenospermia. METHODS: In the present study, 192 patients with idiopathic asthenospermia and 288 healthy controls were enrolled, and a flight mass spectrometry using Sequenom's MassArray biochip system was applied for genotyping 16 CATSPER gene SNPs reported in the human single nucleotide polymorphism (SNP) database. RESULTS: Our results indicated a correlation between CATSPER1 SNPs and idiopathic asthenospermia. In particular, the exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk and is a potential important factor in determining an individual's genetic susceptibility to idiopathic asthenospermia. CONCLUSION: These finding will help to further elucidate the role of CATSPER1 in idiopathic asthenospermia pathogenesis. FAU - Shu, Fangpeng AU - Shu F AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Zhou, Xumin AU - Zhou X AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Li, Fenxia AU - Li F AD - School of Biotechnology, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Lu, Daojun AU - Lu D AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Lei, Bin AU - Lei B AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Li, Qi AU - Li Q AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Yang, Yu AU - Yang Y AD - Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. FAU - Yang, Xuexi AU - Yang X AD - School of Biotechnology, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. shirongphd@126.com. FAU - Shi, Rong AU - Shi R AD - Institute of Genetic Engineering, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. shirongphd@126.com.