• PMID: 25983623
• Gene Name: MTRR
• Condition: Non-obstructive male infertility
• Association: These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
• Mutation: MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms
• Population size: 636
• Population details: 636 (284 infertile men, 352 fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: MTHFR, MTR, MTRR
• Other associated phenotypes: Non-obstructive male infertility

Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population

Kurzawski M, Wajda A, Malinowski D, Kazienko A, Kurzawa R, Drozdzik M.

Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population. FAU - Kurzawski, Mateusz AU - Kurzawski M AD - Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland . FAU - Wajda, Anna AU - Wajda A AD - Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland . FAU - Malinowski, Damian AU - Malinowski D AD - Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland . FAU - Kazienko, Anna AU - Kazienko A AD - Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland . FAU - Kurzawa, Rafal AU - Kurzawa R AD - Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland .