• PMID: 25966116
• Gene Name: MS
• Condition: Azoospermia, oligoasthenozoospermia, Male infertility, Primary infertility
• Association: The findings revealed an association between the single-nucleotide polymorphism A66G in the MTRR gene and male infertility, particularly in oligoasthenozoospermia males, suggesting that this polymorphism is a genetic risk factor for male infertility in Ch
• Mutation: MTRR A66G, MTHFR C677T, A1298C, and MS A2756G
• Population size: 282
• Population details: 282 (162 infertile patients (100 azoospermia, 62 oligoasthenozoospermia), 120 fertile men as controls )
• Sex: Male
• Infertility type: Male infertility
• Associated genes: MTRR, MTHFR, MS
• Other associated phenotypes: Azoospermia, oligoasthenozoospermia, Male infertility, Primary infertility

Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males

Li XY, Ye JZ, Ding XP, Zhang XH, Ma TJ, Zhong R, Ren HY.

We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population. This case-control study included 162 infertile Chinese patients with azoospermia (N = 100) or oligoasthenozoospermia (N = 62) and 120 fertile men as controls. The polymorphisms MTRR A66G, MTHFR C677T, A1298C, and MS A2756G were identified by direct DNA sequencing and the results were statistically analyzed. We found no association between the incidence of any of these variants in azoospermia patients and control populations. The frequency of the MTRR66 polymorphic genotypes (AG, AG+GG) was significantly higher in the oligoasthenozoospermia group compared to the controls (P = 0.013, 0.012). Our findings revealed an association between the single-nucleotide polymorphism A66G in the MTRR gene and male infertility, particularly in oligoasthenozoospermia males, suggesting that this polymorphism is a genetic risk factor for male infertility in Chinese men. FAU - Li, X Y AU - Li XY AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China. FAU - Ye, J Z AU - Ye JZ AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China. FAU - Ding, X P AU - Ding XP AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China brainding@scu.edu.cn. FAU - Zhang, X H AU - Zhang XH AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China. FAU - Ma, T J AU - Ma TJ AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China. FAU - Zhong, R AU - Zhong R AD - Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.