• PMID: 25729253
• Gene Name: NPC2
• Condition: idiopathic oligoasthenozoospermia
• Association: Associated
• Population size: 20
• Population details: 20 (10 men with normozoospermia, 10 men with idiopathic oligoasthenozoospermia)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: idiopathic oligoasthenozoospermia

Correlation between the serum luteinizing hormone to folliclestimulating hormone ratio and the anti-Müllerian hormone levels in normo-ovulatory women

Lee JE, Yoon SH, Kim HO, Min EG.

Serum anti-Müllerian hormone (AMH) levels are regarded as an age-specific marker for predicting the ovarian reserve in women of reproductive age. Some studies have shown that the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio can be used as a predictor of ovarian reserve. The purpose of this study was to assess the variation of LH/FSH ratio with aging and to evaluate the correlation between serum LH/FSH ratio and AMH levels as a predictor of the ovarian reserve in normo-ovulatory women. We retrospectively analyzed the day 3 serum hormone levels in 1,251 patients (age range: 20-50 yr) between January 2010 and January 2011. We divided the patients into 6 groups according to their age. Relation between serum AMH level and LH/FSH ratio was analyzed statistically. The serum AMH level was inversely correlated with age (r = -0.400, P < 0.001). A significant negative correlation was found between serum LH/FSH ratio and age (r = -0.213, P < 0.001). There was a significant partial correlation between serum LH/FSH ratio and AMH level when adjusted by age (r = 0.348, P < 0.001). The LH/FSH ratio could be considered as a useful marker for the ovarian reserve and could be applied to the clinical evaluation with AMH. FAU - Lee, Jong Eun AU - Lee JE AUID- ORCID: 0000-0002-2933-9265 AD - Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. FAU - Yoon, Sang Ho AU - Yoon SH AUID- ORCID: 0000-0003-1754-2212 AD - Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. FAU - Kim, Hye Ok AU - Kim HO AUID- ORCID: 0000-0002-3899-7710 AD - Department of Obstetrics and Gynecology, Kwandong University, Cheil General Hospital, Seoul, Korea.