• PMID: 25628439
• Gene Name: PTPA
• Condition: Spermatogenesis defects, Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Spermatogenesis defects, Male infertility

Ppp2ca knockout in mice spermatogenesis

Pan X, Chen X, Tong X, Tang C, Li J.

Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase involved in meiosis, mitosis, sperm capacitation, and apoptosis. Abberant activity of PP2A has been associated with a number of diseases. The homolog PPP2CA and PPP2CB can each function as the phosphatase catalytic subunit generally referred to as PP2AC. We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-specific manner in primordial germ cells at E12.5. This Ppp2ca-null mutation caused infertility in male C57BL/6J mice. These CKO mice provide a powerful tool to study the mechanisms of Ppp2ca in development and disease. CI - © 2015 Society for Reproduction and Fertility. FAU - Pan, Xiaoyun AU - Pan X AD - Key Laboratory of National Reproductive MedicineDepartment of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China. FAU - Chen, Xia AU - Chen X AD - Key Laboratory of National Reproductive MedicineDepartment of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China. FAU - Tong, Xin AU - Tong X AD - Key Laboratory of National Reproductive MedicineDepartment of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China. FAU - Tang, Chao AU - Tang C AD - Key Laboratory of National Reproductive MedicineDepartment of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China.