• PMID: 25578539
• Gene Name: MTRR
• Condition: Male infertility, azoospermia, oligozoospermia
• Association: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
• Mutation: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G
• Population size: 500
• Population details: 500 (296 idiopathic infertile males with azoospermia or oligozoospermia, 204 fertile males)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: MTHFR, MTR , MTRR
• Other associated phenotypes: Male infertility, azoospermia, oligozoospermia

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

Ni W, Li H, Wu A, Zhang P, Yang H, Yang X, Huang X, Jiang L.

PURPOSE: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. METHODS: The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. RESULTS: We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. CONCLUSIONS: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population. FAU - Ni, Wuhua AU - Ni W AD - Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China. FAU - Li, Haiyan AU - Li H FAU - Wu, Aihua AU - Wu A FAU - Zhang, Peili AU - Zhang P FAU - Yang, Haiyan AU - Yang H FAU - Yang, Xu AU - Yang X FAU - Huang, Xuefeng AU - Huang X