• PMID: 25556380
• Gene Name: KISS1
• Condition: Male infertility, asthenozoospermia, asthenoteratozoospermia, azoospermia, oligozoospermia, oligoasthenozoospermia, oligoasthenoteratozoospermia
• Association: Associated
• Population size: 176
• Population details: 176 (26 fertile and 150 infertile (22 asthenozoospermia, 08 asthenoteratozoospermia, 18 azoospermia, 58 normozoospermia, 06 oligozoospermia, 12 oligoasthenozoospermia and 26 oligoasthenoteratozoospermia))
• Age: 18 - 50 years
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility, asthenozoospermia, asthenoteratozoospermia, azoospermia, oligozoospermia, oligoasthenozoospermia, oligoasthenoteratozoospermia

Insight into the serum kisspeptin levels in infertile males

Ramzan MH, Ramzan M, Ramzan F, Wahab F, Jelani M, Khan MA, Shah M.

BACKGROUND: Regulation of reproduction is now considered to be carried out by the kisspeptin and its receptor, GPR54 or Kiss1r. Mutations of either Kiss1 or Kiss1r in humans and mice result in profound hypogonadotropic hypogonadism. The present study was aimed to determine whether the levels of kisspeptin are associated with male infertility. METHODOLOGY: The study involved 176 male subjects aged 18 - 50 years including 26 fertile and 150 infertile. Infertile subjects were further subdivided according to WHO guidelines of semen analysis into 22 asthenozoospermia, 08 asthenoteratozoospermia, 18 azoospermia, 58 normozoospermia, 06 oligozoospermia, 12 oligoasthenozoospermia and 26 oligoasthenoteratozoospermia. Thorough clinical examinations excluded those suffering from chronic health problems. Serum kisspeptin levels were measured by enzyme immunoassay (EIA) and follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were estimated by chemiluminescence assay (CLIA). RESULTS: The results of the present study have revealed that kisspeptin levels were significantly lower in all infertile males as compared to the fertile males. Significantly low LH and testosterone levels were observed in all infertile groups as compared to fertile group. FSH levels were significantly lower in normozoospermic and azoospermic as compared to fertile males, while no significant difference was observed between the other infertile and fertile group. CONCLUSION: The study revealed that serum kisspeptin levels were observed significantly lower in the infertile as compared to fertile males, indicating that the kisspeptin might be associated with the fertility problems in males. FAU - Ramzan, Muhammad Haris AU - Ramzan MH AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. mohsin_gnu@yahoo.com; mohsin.ibms@kmu.edu.pk. FAU - Ramzan, Muhammad AU - Ramzan M AD - Department of Biochemistry, Peshawar Medical College, Peshawar, Pakistan. FAU - Ramzan, Faiqah AU - Ramzan F AD - Gomal Centre of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan. FAU - Wahab, Fazal AU - Wahab F AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Jelani, Musharraf AU - Jelani M AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Khan, Muhammad Aslam AU - Khan MA AD - Department of Pathology, District Headquarter Teaching Hospital, Dera Ismail Khan, Pakistan.