• PMID: 25418418
• Gene Name: NGF
• Condition: Sperm motility, Male infertiltiy
• Association: Further analysis demonstrated that NGF promoted the sperm motility in a dose-dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Sperm motility, Male infertiltiy

Nerve growth factor promotes human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa

Lin K, Ding XF, Shi CG, Zeng D, QuZong S, Liu SH, Wu Y, LuoBu G, Fan M, Zhao YQ.

Nerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose-dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques. CI - © 2014 Blackwell Verlag GmbH. FAU - Lin, Kai AU - Lin K AD - Clinical Laboratory Center, General Hospital of Air Force, Beijing, China. FAU - Ding, Xue-Feng AU - Ding XF AD - Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China. FAU - Shi, Cui-Ge AU - Shi CG AD - National Research Institute of Family Planning, Beijing, China. FAU - Zeng, Dan AU - Zeng D AD - People's Hospital of Tibet Autonomous Region, Lassa, China. FAU - QuZong, SuoLang AU - QuZong S AD - People's Hospital of Tibet Autonomous Region, Lassa, China. FAU - Liu, Shu-Hong AU - Liu SH AD - Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China. FAU - Wu, Yan AU - Wu Y AD - Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China. FAU - LuoBu, GeSang AU - LuoBu G AD - People's Hospital of Tibet Autonomous Region, Lassa, China. FAU - Fan, Ming AU - Fan M AD - Department of Cognitive Sciences, Beijing Institute of Basic Medical Sciences, Beijing, China.