• PMID: 25395209
• Gene Name: Sin3A
• Condition: Azoospermia
• Association: Not associated
• Population size: 80
• Population details: 80 Sertoli cell-only syndrome (SCOS)
• Sex: Male
• Infertility type: Male infertility

SIN3A mutations are rare in men with azoospermia

Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Minase G, Ueda Y, Namiki M, Sengoku K.

A loss of function of the murine Sin3A gene resulted in male infertility with Sertoli cell-only syndrome (SCOS) phenotype in mice. Here, we investigated the relevance of this gene to human male infertility with azoospermia caused by SCOS. Mutation analysis of SIN3A in the coding region was performed on 80 Japanese patients. However, no variants could be detected. This study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by SCOS in humans. CI - © 2014 Blackwell Verlag GmbH. FAU - Miyamoto, T AU - Miyamoto T AD - Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan. FAU - Koh, E AU - Koh E AD - Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. FAU - Tsujimura, A AU - Tsujimura A AD - Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan. FAU - Miyagawa, Y AU - Miyagawa Y AD - Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan. FAU - Minase, G AU - Minase G AD - Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan. FAU - Ueda, Y AU - Ueda Y AD - Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan. FAU - Namiki, M AU - Namiki M AD - Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.