• PMID: 25130880
• Gene Name: GSTM1
• Condition: Idiopathic male infertility
• Association: In the control group, men with GSTM1 null genotype had significantly lower spermconcentrations but not total sperm count when compared with men with GSTM1-positive genotype. The results of this study suggest a possible negative effect of GSTM1 null genoty
• Population size: 120
• Population details: 120 (60 with primary idiopathic infertility, 60 fertile men as controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic male infertility

Glutathione S-transferase Mu-1 gene polymorphism in Egyptian patients with idiopathic male infertility

Roshdy OH, Hussein TM, Zakaria NH, Sabry AA.

The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The frequency of GSTM1 null genotype was observed to be higher in infertile men 40% in comparison with 33.3% in the fertile men, but this difference was not statistically significant. There was statistically significant difference between cases and controls as regards GSTM1 genotype distribution ((MC) P = 0.006*) in GSTM1-positive men. Patients with the GSTM1 null genotype had significantly lower sperm concentrations and total sperm count when compared with patients with GSTM1-positive genotype. In the control group, men with GSTM1 null genotype had significantly lower sperm concentrations but not total sperm count when compared with men with GSTM1-positive genotype. The results of this study suggest a possible negative effect of GSTM1 null genotype on the spermatogenic potential of the testis. CI - © 2014 Blackwell Verlag GmbH. FAU - Roshdy, O H AU - Roshdy OH AD - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt. FAU - Hussein, T M AU - Hussein TM FAU - Zakaria, N H AU - Zakaria NH