• PMID: 25063483
• Gene Name: IL1R2
• Condition: Endometriosis
• Association: Associated

[Endometriosis: increasing concentrations of serum interleukin-1? and interleukin-1sRII is associated with the deep form of this pathology]

Lambert S, Santulli P, Chouzenoux S, Marcellin L, Borghese B, de Ziegler D, Batteux F, Chapron C.

OBJECTIVES: To assess interleukin-1β (IL-1β) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity. PATIENTS AND METHODS: In this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1β and IL-1sRII have been evaluated using Elisa. RESULTS: IL-1β and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1β was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-free women (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01). CONCLUSION: This study highlights both a marked significant increase in serum IL-1β and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis. CI - Copyright © 2014 Elsevier Masson SAS. All rights reserved. FAU - Lambert, S AU - Lambert S AD - Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: lambertsixtine@gmail.com. FAU - Santulli, P AU - Santulli P AD - Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. FAU - Chouzenoux, S AU - Chouzenoux S AD - Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France. FAU - Marcellin, L AU - Marcellin L AD - Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. FAU - Borghese, B AU - Borghese B AD - Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. FAU - de Ziegler, D AU - de Ziegler D AD - Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. FAU - Batteux, F AU - Batteux F AD - Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France.