• PMID: 25029857
• Gene Name: OGG1
• Condition: Male infertility
• Association: OGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population.
• Mutation: OGG1 326 Cys/Cys
• Population size: 1005
• Population details: 1005 (620 idiopathic infertile patients, 385 normal fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with male infertility]

Chen JZ, Wu SM, Ji GX, Gu AH.

OBJECTIVE: To explore the association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with semen quality and the risk of male infertility. METHODS: This case-control study included 620 idiopathic infertile patients and 385 normal fertile controls. We determined their genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analyzed their semen quality by computer-aided semen analysis (CASA). RESULTS: The individuals with OGG1 326 Cys/Cys showed significantly lower sperm motility and concentration ([52.1 +/- 26.7]% and (3.75 +/- 0.91) x 10(6)/ml, ln transformed value) than the Ser/Ser carriers ([59.0 +/- 21.8] % and (4.12 +/- 0.88) x 10(6)/ml, ln transformed value) (P < 0.05). The risk of male infertility increased 69% in the OGG1 326Cys allele carriers as compared with the Ser carriers (OR = 1.69, 95% CI: 1.24 -2.31). CONCLUSION: OGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population. FAU - Chen, Jian-Zhong AU - Chen JZ FAU - Wu, Sheng-Min AU - Wu SM FAU - Ji, Gui-Xiang AU - Ji GX