• PMID: 24768523
• Gene Name: MAPT
• Condition: Deacetylation of microtubules in mouse spermatogenic cells during meiosis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Deacetylation of microtubules in mouse spermatogenic cells during meiosis

Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis

Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, Fukuda Y, Nakai Y, Uchida T, Sato E, Tanemura K.

Tau is one of the microtubule-associated proteins and a major component of paired helical filaments, a hallmark of Alzheimer's disease. Its expression has also been indicated in the testis. However, its function and modification in the testis have not been established. Here, we analyzed the dynamics of phosphorylation patterns during spermatogenesis. The expression of Tau protein and its phosphorylation were shown in the mouse testis. Immunohistochemistry revealed that the phosphorylation was strongly detected during meiosis. Correspondingly, the expression of acetylated tubulin was inversely weakened during meiosis. These results suggest that phosphorylation of Tau protein contributes to spermatogenesis, especially in meiosis. CI - Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. FAU - Inoue, Hiroki AU - Inoue H AD - Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Hiradate, Yuuki AU - Hiradate Y AD - Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Shirakata, Yoshiki AU - Shirakata Y AD - Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Kanai, Kenta AU - Kanai K AD - Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Kosaka, Keita AU - Kosaka K AD - Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Gotoh, Aina AU - Gotoh A AD - Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Fukuda, Yasuhiro AU - Fukuda Y AD - Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan. FAU - Nakai, Yutaka AU - Nakai Y AD - Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan. FAU - Uchida, Takafumi AU - Uchida T AD - Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan. FAU - Sato, Eimei AU - Sato E AD - National Livestock Breeding, 1 Odakurahara, Odakura, Nishigo-mura, Nishishirakawa-gun, Fukushima 961-8511, Japan.