• PMID: 24464679
• Gene Name: CIB1
• Condition: Oligoasthenozoospermia
• Association: The results of the present study indicate that that CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 signaling pathway.
• Population size: 44
• Population details: 44 (25 infertile men ( oligoasthenozoospermia (n?=?13), asthenozoospermia (n?=?12), 19 fertile men)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligoasthenozoospermia

Calcium- and integrin-binding protein-1 is down-regulated in the sperm of patients with oligoasthenozoospermia : CIB1 expression in patients with oligoasthenozoospermia

Sun W, Guan Q, Wen J, Zhang Q, Yang W, Zhang B, Cui W, Zou Z, Yu Y.

PURPOSE: The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of patients with oligoasthenozoospermia. METHODS: Sperm samples were obtained from 25 infertile Chinese men who had failed to achieve conception after a period of 1-2 y and had been referred to the Reproductive Laboratory of the second hospital affiliated to the Shandong University of Traditional Chinese Medicine. Participants were divided into two groups: oligoasthenozoospermia (n = 13) and asthenozoospermia (n = 12); as a third group, fertile men (n = 19) were included as controls. The expression levels of mRNA and protein levels of CIB1 and cyclin-dependent kinase 1 (CDK1) were measured using qRT-PCR and western blotting. RESULTS: mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients. Interestingly mRNA and protein expression levels of CDK1 were increased in the oligoasthenozoospermia patients. CONCLUSION: The results of the present study indicate that that CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 signaling pathway. FAU - Sun, Wei AU - Sun W AD - Reproductive Medical Center, the Second Hospital affiliated to Shandong University of Traditional Chinese Medicine, Jingba Road, Jinan, 250001, People's Republic of China. FAU - Guan, Qun AU - Guan Q FAU - Wen, Ji AU - Wen J FAU - Zhang, Qiyao AU - Zhang Q FAU - Yang, Weina AU - Yang W FAU - Zhang, Bin AU - Zhang B FAU - Cui, Wei AU - Cui W FAU - Zou, Zhiquan AU - Zou Z