• PMID: 24456074
• Gene Name: CAT
• Condition: Male infertility
• Association: Taking into accounts of results, the catalase C-262T polymorphism indicates that CAT-262T/T genotype confers less susceptibility to male infertility.
• Mutation: C-262T polymorphism
• Population size: 385
• Population details: 385 (195 men with idiopathic infertility, 190 healthy volunteers)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Human catalase gene polymorphism (CAT C-262T) and risk of male infertility

Sabouhi S, Salehi Z, Bahadori MH, Mahdavi M.

Infertility is the failure of a couple to engender after endeavouring at least one full year of unprotected intercourse. It has been reported that reactive oxygen species contributed to pathogenesis of various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, one of them is catalase which contributes H2 O2 to H2 O and O2 . This study set out to delineate the association of catalase C-262T polymorphism with idiopathic male infertility. The study included 195 men with idiopathic infertility and 190 healthy volunteers. Genomic DNA was extracted from peripheral blood leucocytes. Genotype and allele frequencies were determined in patients and controls using allele-specific PCR (AS-PCR). The prevalence of genotype frequencies of the CAT CC/CT/TT was 31.79%, 65.12% and 3.07%, respectively, in infertile subjects, as against 24.73%, 55.26% and 20%, respectively, in healthy volunteers. Statistical analysis has emerged significant difference from the comparison of either genotype (P < 0.05). Taking into accounts of results, the catalase C-262T polymorphism indicates that CAT-262T/T genotype confers less susceptibility to male infertility. Further studies with larger numbers of patients are required for further evaluation and confirmation of our finding. CI - © 2014 Blackwell Verlag GmbH. FAU - Sabouhi, S AU - Sabouhi S AD - Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran. FAU - Salehi, Z AU - Salehi Z FAU - Bahadori, M H AU - Bahadori MH