• PMID: 24333229
• Gene Name: IL-18
• Condition: Male infertility
• Association: The IL-18 levels of semen in the abnormal group (810.91 pg/mL) were higher than that of the normal group. Analyses indicate that seminal fluid IL-18 positively correlates with IL-6, IL-8, and tumor necrosis factor-?. Seminal IL-18 level does not affect ba
• Population size: 57
• Population details: 57 infertile and normal males
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

IL-18 levels in the semen of male infertility: semen analysis

Qian L, Zhou Y, Du C, Wen J, Teng S, Teng Z.

This study investigated the relationship between interleukin (IL)-18 levels and male infertility. Semen samples from 57 infertile and normal males were subjected to semen analysis. The pH of the semen samples from normal and abnormal groups showed no significant difference (p>0.05). However, semen volume, density, forward movement percentage, activity, survival rate, and normal morphology rate of the sperms in the normal group were significantly higher than those of the abnormal group (p<0.01). The IL-18 levels of semen in the abnormal group (810.91 pg/mL) were higher than that of the normal group (402.74 pg/mL; p<0.01). Analyses indicate that seminal fluid IL-18 positively correlates with IL-6, IL-8, and tumor necrosis factor-α. Seminal IL-18 level does not affect bacterial colony count. Results indicate that IL-18 may be important in male reproduction. CI - Copyright © 2013 Elsevier B.V. All rights reserved. FAU - Qian, Li AU - Qian L AD - Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: qianli008@yahoo.com. FAU - Zhou, Yan AU - Zhou Y AD - Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: zhoulygsh@sina.com. FAU - Du, Chunling AU - Du C AD - Department of Nursing, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. FAU - Wen, Jiangtao AU - Wen J AD - Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. FAU - Teng, Shijie AU - Teng S AD - Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.