• PMID: 24316127
• Gene Name: CYP1A1
• Condition: Idiopathic male infertility
• Association: In conclusion, these results support that the CYP1A1 2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians.
• Population size: 2285
• Population details: 2285 (1,060 cases, 1,225 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic male infertility

The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: a meta-analysis

Fang J, Wang S, Wang H, Zhang S, Su S, Song Z, Deng Y, Qian J, Gu J, Liu B, Cao J, Wang Z.

Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed a meta-analysis based on 1060 cases and 1225 controls from 7 published case-control studies. PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele-frequency genetic model. In the overall analysis, the frequency of CYP1A12A genotype was significantly associated with susceptibility to idiopathic male infertility. Further stratified analysis by ethnicity showed notable association between the polymorphism and the risk of idiopathic male infertility in Asians. In conclusion, these results support that the CYP1A1 2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians. CI - Copyright © 2013 Elsevier B.V. All rights reserved. FAU - Fang, Jianzheng AU - Fang J AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Wang, Shangqian AU - Wang S AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Wang, Hainan AU - Wang H AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Zhang, Shengli AU - Zhang S AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Su, Shifeng AU - Su S AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Song, Zhen AU - Song Z AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Deng, Yunfei AU - Deng Y AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Qian, Jian AU - Qian J AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Gu, Jinbao AU - Gu J AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Liu, Bianjiang AU - Liu B AD - State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. FAU - Cao, Jingyi AU - Cao J AD - Department of Urology, Xuzhou Third People's Hospital, Xuzhou 221000, China.