• PMID: 24168058
• Gene Name: THRB
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility

Jaiswal D, Trivedi S, Agrawal NK, Singh K.

Gonadotrophin-regulated testicular RNA helicase (GRTH) plays an important role in RNA functions including nuclear transcription, pre-mRNA splicing and it regulates the translation of specific genes required for the progression of spermatogenesis. In this study, we analysed the association of GRTH gene IVS6+55G/T and c.852C/T polymorphisms with human male infertility. The study showed c.852 T allele was associated with an increased risk of male infertility (OR: 3.16, P = 0.008), whereas IVS6+55G/T allele conferred no risk. In Indian population, this is the first report on association of GRTH gene SNP polymorphism and male infertility and it underscores the significance of GRTH genotypes in modulating the risk of male infertility. CI - © 2013 Blackwell Verlag GmbH. FAU - Jaiswal, D AU - Jaiswal D AD - Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India. FAU - Trivedi, S AU - Trivedi S FAU - Agrawal, N K AU - Agrawal NK