• PMID: 24006281
• Gene Name: KDM3A
• Condition: Maintanence of male germ cells
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Maintanence of male germ cells

JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice

Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, Shinkai Y, Tachibana M.

JmjC domain-containing proteins are a class of enzymes responsible for histone demethylation. Previous studies revealed that the JmjC domain-containing protein KDM3A possesses intrinsic demethylase activity toward lysine 9 of histone H3 and plays essential roles in spermiogenesis. In contrast, the biological roles of JMJD1C, a KDM3A homolog in mice, are largely unknown. Here we present the crucial role of JMJD1C in male gametogenesis. Jmjd1c-deficient males became infertile due to the progressive reduction of germ cells after 3 mo of age. Importantly, Jmjd1c-deficient testes frequently contained abnormal tubules lacking developmentally immature germ cells. JMJD1C is most abundantly expressed in undifferentiated spermatogonia in mouse testis. The numbers of ZBTB16-positive spermatogonia and apoptotic germ cells in Jmjd1c-deficient testes decreased and increased in an age-dependent manner, respectively. Our studies demonstrated that JMJD1C contributes to the long-term maintenance of the male germ line. FAU - Kuroki, Shunsuke AU - Kuroki S AD - Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan. FAU - Akiyoshi, Mika AU - Akiyoshi M FAU - Tokura, Mikiyo AU - Tokura M FAU - Miyachi, Hitoshi AU - Miyachi H FAU - Nakai, Yuji AU - Nakai Y FAU - Kimura, Hiroshi AU - Kimura H FAU - Shinkai, Yoichi AU - Shinkai Y