• PMID: 23912751
• Gene Name: coenzyme Q10
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Coenzyme Q10 and male infertility: a meta-analysis

Lafuente R, González-Comadrán M, Solà I, López G, Brassesco M, Carreras R, Checa MA.

OBJECTIVE: To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility. MATERIALS AND METHODS: Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group. RESULTS: None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I(2) = 17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I(2) = 58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I(2) = 0 %) CONCLUSION: There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice. FAU - Lafuente, Rafael AU - Lafuente R AD - Andrology Laboratory, CIRH. Clínica Corachan. ANACER, Eguilaz, 14, bajos, 08017, Barcelona, Spain, rlafuente@cirh.es. FAU - González-Comadrán, Mireia AU - González-Comadrán M FAU - Solà, Ivan AU - Solà I FAU - López, Gemma AU - López G FAU - Brassesco, Mario AU - Brassesco M FAU - Carreras, Ramón AU - Carreras R